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Biomedical subjects

J Rajfer

Publications and source records attributed to J Rajfer.

At least 163 records · Page 9Linked to original sources
PubMed1982

Thrombotic microangiopathy: recurrence following renal transplant and response to plasma infusion.

Recurrence of thrombotic microangiopathy (TMA) has rarely been reported following renal transplantation. We describe a 24-year-old man who developed irreversible renal failure due to thrombotic microangiopathy. Following renal transplantation, he developed recurrent episodes of microangiopathic hemolysis; during one of these episodes a biopsy revealed the development of thrombotic microangiopathy in the graft. In each of five recurrences to date, plasma infusion, either alone or combined with other forms of therapy, has produced a prompt remission. This is the first report, to our knowledge, of the successful treatment of recurrent TMA in a renal transplant recipient.

Adult↗
PubMed1981

A new and simplified method for concealing the hypertrophied clitoris.

Current surgical procedures that are utilized in the management of patients with an enlarged clitoris are both complex and challenging. We report a new method of concealing the hypertrophied clitoris between the labia majora instead of resorting to the more difficult clitoral amputation or recession. This concealment of the clitoris is simple, may be done on an outpatient basis, and accomplishes the goal of creating normal-appearing female external genitalia.

Clitoris↗
PubMed1981

Association between Wilms tumor and gonadal dysgenesis.

The classification of intersexuality was determined in 10 patients with an intersex disorder who subsequently suffered a Wilms tumor. Of these 10 patients 7 (70 per cent) had a disorder of gonadal dysgenesis: 5 had mixed gonadal dysgenesis, 1 had dysgenetic male pseudohermaphroditism and 1 had 46XY pure gonadal dysgenesis. Because the gonads of patients with either of these 3 disorders have a high predilection for the development of testicular neoplasia, the concomitant occurrence of renal tumors in such a patient population suggests that a common defect in the urogenital ridge, the embryonic precursor of the kidneys and gonads, may be the cause of this association.

Child↗
PubMed1981

Morphological study of testicular descent in the rabbit.

We studied the morphologic changes in the rabbit gubernaculum that occur just before and at the time of testicular descent. Our findings suggest that in the rabbit the gubernaculum may be the target tissue responsible for the movement of the testis from the abdomen into the scrotum.

Animals↗
PubMed1979

Effects of neonatal steroids on male sex tissues.

The effects of neonatally administered sex hormones on the growth and hormone responsiveness of the sex accessory tissues of the adult male rat were investigated. If intact neonatal male rats are treated with estradiol diproprionate, the size of the ventral prostate in the adult animal at day 70 of age is less than 10 per cent of the untreated control value. If androgens are administered to intact neonates, the size of the ventral prostate at day 70 is one-third to one-half of the untreated control values. The androgenic response of these abnormally small prostates was tested by treating these adult animals with testosterone propionate daily from day 70 to day 83. Toward ventral prostates of the animals treated with estrogens in the neonatal period show a very limited response to exogenous androgens at adulthood. In contrast, the ventral prostates of the animals receiving testosterone propionate or dihydrotestosterone propionate in the neonatal period were fully responsive to exogenous androgens. In addition, the ability of the adult prostate to respond fully to androgens requires the presence of the testes in the neonatal period. Comparing neonatal castrates with intact neonates, it was shown that the administration of androgen in the neonatal period was only partially effective in restoring the androgenic responsiveness of the adult ventral prostate. This suggests that other testicular factors, or the presence of testosterone at other time periods before the onset of puberty, may be necessary for the normal androgenic induced response of the adult sex accessory tissues.

Animals↗
PubMed1978

Dysgenetic male pseudohermaphroditism.

Dysgenetic male pseudohermaphroditism is a disorder of sexual differentiation in which patients present with bilateral dysgenetic testes, persistent müllerian structures, cryptorchidism and inadequate virilization. There were 10 patients with this syndrome seen at our hospital between 1956 and 1976. In this series, there was a 30 per cent incidence of testicular tumors. Because patients with dysgenetic male pseudohermaphroditism have a high incidence of testicular tumors this disorder, which is actually a variant of mixed gonadal dysgenesis, must be distinguished from the other forms of male pseudohermaphroditism.

Adult↗
PubMed1978

Testicular descent. Normal and abnormal.

The subject of testicular descent has been reviewed. An attempt has been made to present a basic understanding of the embryology and mechanisms of this event. The abnormalities of testicular descent have also been discussed, including the pathogenesis and complications of this disorder, which is the most common developmental abnormality in childhood. The aims and results of both the hormonal and surgical treatments of cryptorchidism have been summarized. From data gleaned from the literature, a plea is made for the earlier treatment of the undescended testis in patients under five years of age.

Animals↗
PubMed1978

Sex steroid imprinting of the immature prostate. Long-term effects.

New periods of sex hormone sensitivity in the life cycle of the male rat that occur before the onset of sexual maturation and that determine subsequent responsiveness and growth of the adult prostate have been elucidated. If high doses of estrogen (17 beta-estradiol--500 microgram per day, or estradiol benzoate--250 micrograms per day, or estradiol dipropionate--100 micrograms per day) are administered to intact male rats for 2 days during the 1st week after birth, the prostate, at adulthood, is diminutive in size and is inert to the action of exogenous androgens. In contrast, lower doses of estrogen (17 beta estradiol--100 micrograms per day) administered at 20 and 22 days of age enhance the sensitivity of the adult prostate to testosterone by approximately 50 per cent. Furthermore, it has been determined that continued testicular function is required up to the time of puberty for full prostatic growth.

Age Factors↗
PubMed1977

Hormonal regulation of testicular descent: experimental and clinical observations.

Hormonal regulation of testicular descent has been investigated. Based on experimental studies using the rat and on a review of clinical material it has been determined that testicular descent is an androgen-mediated event directly under the regulation of pituitary gonadotropin. Furthermore, the active androgenic metabolite involved in this process appears to be dihydrotestosterone, which is synthesized by the testis and must be present in high local concentrations to be effective. In addition to these hormonal requirements the anatomy of the inguinal canal must provide unimpeded migration of the testis into the scrotum. Any imbalance or anomaly of these prerequisites may lead to cryptorchidism.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗