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Biomedical subjects

J Radhakrishnan

Publications and source records attributed to J Radhakrishnan.

67 records · Page 4Linked to original sources
PubMed1980

Pediatric pyleoplasty.

A series is reviewed of 153 pyeloplasties in 130 pediatric patients. Dismembering pyeloplasty was performed in most cases, usually with temporary nephrostomy drainage. A satisfactory anastomosis resulted in each case. The important technical aspects of pyeloplasty are emphasized.

Adolescent↗
PubMed1979

Choledochal cyst with cholelithiasis: 15-yr follow-up.

A 15-yr-old boy, who had had surgery for a choledochal cyst in infancy, was worked up for recurrent right upper quandrant pair. Intravenous cholangiogram and ultrasound demonstrated a choledochal cyst with stones. Angiogram showed only a distorted branch of the gastro-duodenal artery. These findings were confirmed at surgery.

Adolescent↗
PubMed1979

Bronchial carcinoid tumor.

Bronchial carcinoid tumor occurring in an 11-yr-old boy is described. Pertinent diagnostic and therapeutic considerations are discussed briefly.

Bronchial Neoplasms↗
PubMed1979

Observations on the gubernaculum during descent of the testis.

The mechanisms that influence the descent of the testis are not clearly understood. The gubernaculum is a structure worthy of scrutiny inasmuch as it is conspicuous during descent, but virtually disappears after descent is complete. Early in gestation, the rat gubernacular bulb consists of loose mesenchymal cells that develop into fibrillar cells. These later thicken into rhabdomyoblasts that, near the end of gestation, differentiate into spiral striated muscle bundles, and eventually migrate outward into the abdominal/scrotal wall. The rhabdomyoblasts of the female gubernaculum do not differentiate further but rather undergo fatty degeneration. It is possible that spiral contractions of the attached gubernaculum produce tension on the testis and induce descent. The gubernaculum as the receptor organ for testicular descent may be responsive to local testicular hormones. Likely candidates are testosterone, dihydrotestosterone, or Mullerian Inhibiting Substance. A thorough knowledge of the sequential differentiation of the gubernaculum during embryonic development sets the stage for the study of its response to hormonal manipulation both in vivo and in vitro.

Animals↗
PubMedDate not supplied

Antenatal urologic intervention: current status.

The devastation caused by fetal obstructive uropathy is now well known. At the most severe end of the spectrum of obstructive uropathy not only is the developing kidney damaged but the resultant oligohydra-mnios prevents pulmonary development and causes skeletal defects. The most significant changes are noted in patients with posterior urethral values (PUV). The obvious solution to the problem is to either correct or by pass the obstruction prior to the development of permanent changes. Unfortunately, this simple concept is not easy to apply since it raises numerous ethical, legal, economic and technical problems.

Female↗