Plasma testosterone values were established by the protein-binding method in 45 married patients who at the age of 36-55 were examined for sexual disinterest and/or disturbances of penile erection. The control group consisted of 108 men whose ejaculate was normospermic and who reported adequate coital activity. The average values of male sex hormone in all age subgroups of patients with functional sexual disorders were lower than those of the control group. However, in patients with a pathological somatosexual finding (chromatin-positive men, patients with a varicocele), where the plasma testosterone level was approximately the same as in patients with functional sexual disorders, similar coital activity was found as in the control group of normospermic men.

Adult↗

PubMed1975

Incidence of hypospadia and epispadia in chromatin-positive men.

There are described some results of examination of three patients with a Klinefelter's syndrome two of whom had a heavy form of hypospadia, and one suffered from epispadia. The disturbances of penis development are explained, with respect to findings in adult age, by the insensibility of target tissues to the effect of testicular androgen. This insensibility was already acting in the third month of intrauterine life of the fetus.

Adult↗

PubMed1975

Plasmatic testosterone values in 105 Klinefelters.

Clinical, spermiologic and karyologic examinations and determinations of plasmatic testosterone were performed in a group of 105 chromatin-positive patients aged 16 to 45 years. A comparison with a control group of 108 somatosexually well developed and fertile men at the age of 21 to 55 years has established that in the Klinefelter's syndrome the male sex hormone level in the blood was highly significantly lower. Whereas in the control group the male sex hormone values in the blood were dependent on age, it was not possible to prove any dynamic changes in the process of ageing between 21 and 45 years in chromatin-positive patients. A comparison of some phenotypical and laboratory findings in the various chromosomal variants of Klinefelter's syndrome shows that comparatively the least changes were found in patients with a mosaic of 46,XY/47,XXY.

Adolescent↗

PubMed1975