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Biomedical subjects

J R Wittenborn

Publications and source records attributed to J R Wittenborn.

At least 37 records · Page 2Linked to original sources
PubMed1977

Persisting symptoms in schizophrenia predicted by background factors.

A social worker's Home Inquiry was conducted for 75 schizophrenic males as soon as possible after hospitalization. A standard set of items based on this inquiry was scored in terms of nine factors. These Home Inquiry factor scores were found to have modest but statistically significant correlations with specific symptom ratings conducted two years after admission. In the present sample, an interpersonally uncomfortable childhood home and low premorbid self-esteem have untoward implications for the remission of symptoms.

Adult↗
PubMed1976

A comparison of the effect of imipramine, nomifensine, and placebo on the psychomotor performance of normal males.

Imipramine (50 mg), nomifensine (50 mg) or placebo was administered early morning, late morning, and mid-afternoon to normal volunteers. The program of hourly tests included: the Digit Symbol Substitution, Perceptual Reversal, Time Estimation Test, and Simple and Complex Continuous Performances tests both of which required recognition of briefly exposed letters of the alphabet. It was found that relative to placebo or nomifensine, imipramine had a clearly detracting effect on most of the tests. Drowsiness was reported more often in the imipramine group than in the placebo and nomifensine groups combined.

Adult↗
PubMed1976

The effect of minor tranquilizers on psychomotor performance.

The effect of a standard daily regimen of chlordiazepoxide, prazepam (a new benzodiazepine tranquilizer), and placebo were examined in a three way double-blind comparison for a sample of normal volunteers. The criteria include a limited spectrum of psychomotor functions. A learning effect was conspicuous for all drugs on all criteria during the day-long sequence of ten trials. For the most part the differences between the drug groups were insignificant, but there were distinctive modifications in the performance of the chlordiazepoxide group. The clearest effect of the tranquilizer medications was found in the time estimation tests. Paradoxically, the drugs correct a naturally occurring perceptual error.

Adult↗
PubMed1975

A comparison of antidepressant medications in neurotic and psychotic patients.

The responses of 225 newly hospitalized depressed women to amitriptyline hydrochloride, imipramine hydrochloride, and thioridazine were compared with particular reference to the psychotic-neurotic distinction. During the first week, more psychotic patients required sedation and more antidepressant medication than did neurotic patients. All treatment groups showed improvement in psychometric criteria after the first week. There was decreasing improvement through the successive weeks, and no statistically significant differences among treatments emerged. Responses of the neurotic group were superior to those of the psychotic group, but there was no psychometric evidence of interaction between diagnostic classification and treatment effect. The results do not support the hypothesis that any one of these treatments is preferable for neurotic patients or for psychotic patients.

Adult↗