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Biomedical subjects

J R Wilcox

Publications and source records attributed to J R Wilcox.

4 recordsLinked to original sources

Bone scanning in the evaluation of exercise-related stress injuries.

Bone scintigraphy was used to evaluate 34 patients with the physical findings and history of stress fracture of the lower extremity. Of the 34, 21 had abnormal studies, 11 involving the femoral neck, 9 the tibia, and 1 the femur. All of these had abnormal scintiscans prior to or at the time of the appearance of radiographic changes. Of the 9 with abnormal tibial studies, radiographic changes never evolved in 3. No false negatives were found among the 13 with normal scintiscans.

Adolescent

Thyroid uptake of 131I: further comparisons of capsules and liquid preparations.

Comparisons were made of thyroid uptake of three commercially available preparations of 131I, using a double-blind design, in 125 patients with normal thyroid function. Uptakes with Squibb Iodotope Diagnostic capsules were significantly lower than those with Squibb Iodotope Oral liquid at 4 hr (p less than 0.01) and 24 hr (p less than 0.05) after ingestion in both the general population and in all patients less than 45 years of age. Uptakes of Radiocaps I-131 (Abbott Laboratories) and Iodotope Oral liquid were indistinguishable under identical conditions. Our findings indicate that interference with either absorption or metabolism of a pharmaceutical can result from the vehicle used to administer it.

Administration, Oral