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Biomedical subjects

J R Walton

Publications and source records attributed to J R Walton.

At least 55 records · Page 3Linked to original sources
PubMed1983

Review of a bronchial hygiene evaluation program.

In the 1970s the demand in our hospital for bronchial hygiene therapy (aerosols, IPPB, incentive spirometry, chest physical therapy) had increased to such a level that 20-30% of the ordered therapy was not being administered. Because the respiratory therapists and medical directors were convinced that much of the ordered therapy was unnecessary, the Respiratory Therapy Department began a program in 1978 in which specially trained respiratory therapists were authorized to evaluate all non-intensive-care patients for whom bronchial hygiene therapy had been ordered. The program protocol consists of a medical record review, a physical assessment of the patient, the development of a patient-care plan, and a re-evaluation every 2-3 days of the patient's continued need for therapy. We found that initiation of the program has led to improved documentation of the need for bronchial hygiene therapy and a significant decrease in total procedures performed, not merely a substitution of therapies. After being adjusted to the 1981 Consumer Price Index (CPI), total charges for bronchial hygiene therapy were markedly decreased even though hospital charges increased 77.4% above the CPI inflation rate. Since the program was begun, the respiratory therapy staff has been able to administer all ordered respiratory care services to patients in a critical care setting and not less than 90% of ordered bronchial hygiene therapy to patients outside the intensive care unit. House staff, attending physicians, and patients and their families appear to be satisfied with the therapist-evaluators, and the morale of respiratory therapists seems to have improved as a result of their being able to take a more role in the treatment of their patients and to apply their skills to the patients most in need of them.

Analysis of Variance↗
PubMed1979

Properties of epithelial cells cultured from human carcinomas and nonmalignant tissues.

Human epithelial cell cultures were examined for expression of plasminogen activator and fibronectin matrix. All of the cells examined showed ultrastructural evidence suggesting their epithelial origin, including microvilli and specialized junctions. The nonmalignant cells were also negative for endothelial cell markers (ie. they lacked factor VIII antigen, a nonthrombogenic surface and Weibel-Palade bodies). The nonmalignant lines all produced large amounts of plasminogen activator, whereas the tumor-derived lines showed a gradation of activities, ranging from lines having as much activity as the nonmalignant lines to lines having little or no activity above background. For both normal and malignant cells, addition of dexamethesone only slightly decreased the levels of plasminogen activator. By immunofluorescence microscopy, normal bladder and fetal intestine epithelial cells showed fibronectin in a globular and fibrillar matrix. In contrast, normal mammary epithelial cells had a much diminished amount of fibronectin with a punctate distribution.

Binding Sites↗
PubMed1978

Treatment of transplanted murine tumors with an oncolytic virus and cyclophosphamide.

Effective treatment of transplanted murine mammary tumors with an oncolytic virus and cyclophosphamide is reported. The oncolytic virus was cultured initially from a murine ascites tumor that had undergone "spontaneous" regression. This virus used alone causes rapid lysis of ascites tumors, but successful treatment of solid tumors requires the addition of cyclophosphamide. The virus must be injected directly into the tumor. The virus causes no detectable disease in mice even when administered in conjunction with cyclophosphamide. Fluorescent antibody techniques revealed that all A/S stock mice have antibody against cells infected with this virus.

Animals↗
PubMed1978

A stable blood product for pH-blood-gas quality control.

We describe how to prepare, store, and use a hemolyzed blood product for simultaneous pH, pCO2, and pO2 quality control. Tonometry of the blood product with two oxygen and two carbon dioxide concentrations resulted in consistent and reproducible values during 38 weeks. The resulting pH values were consistent and reproducible, demonstrating the metabolic acid-base stability of the blood product. We conclude that the proper preparation, storage, and use of the product results in consistent, reproducible, and economical quality control for pH, pCO2 and pO2 blood measurements.

Blood Chemical Analysis↗