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Biomedical subjects

J R Tighe

Publications and source records attributed to J R Tighe.

At least 37 records · Page 2Linked to original sources
PubMed1975

Evidence of gentamicin nephrotoxicity in patients with renal allografts.

Renal damage was assessed by measuring urinary enzyme excretion in 180 patients with renal allografts. Thirty-six of these patients were studied during 53 courses of treatment with antimicrobial agents which was the only antimicrobial agent which was associated with an increase in urinary enzyme activity. There was usually also evidence of reduced renal function. Renal morphological changes similar to those produced by gentamicin in rats were observed in human allograft biopsy specimens obtained during gentamicin treatment.

Acetylglucosaminidase↗
PubMed1973

Preliminary evaluation of "duodenitis" by endoscopy and biopsy.

Difficulty in excluding duodenal ulceration by standard radiology has hampered investigation of duodenitis; endoscopy and biopsy add a new dimension. We have studied 51 patients with dyspeptic symptoms or bleeding in whom endoscopy revealed congested and irregular areas of duodenal bulb mucosa in the absence of ulcer or scar. Biopsy revealed unequivocal active inflammation-epithelial cell atypia and neutrophil infiltration-in 22 of these patients, but in none of 29 "control" patients with an endoscopically normal bulb. There were no reliable radiological markers of active duodenitis. These patients, and a group of 25 with known duodenal ulcers, shared similar clinical characteristics and a high incidence of gastric metaplasia in the bulb. In the short follow-up period most patients with active duodenitis remained symptomatic; two developed ulcers, and two others have undergone vagotomy and pyloroplasty, with poor short-term results. The clinical significance of visual and histological mucosal changes, and their relationship with ulcer disease, merit long-term study.

Adolescent↗
PubMed1973

Recurrent haematuria and mesangial IgA deposition.

Six patients are described in whom recurrent haematuria was associated with IgA deposits in the glomerular mesangium. These patients conform closely to the nephropathy described by Berger. The condition can only be definitely diagnosed by immunofluorescence techniques. These six patients were diagnosed in one renal unit within 18 months and, despite the absence of reports from British units, this nephropathy is probably not uncommon. No treatment for it is known at present but the prognosis appears to be good in most patients. Renal failure and hypertension have been reported and long-term follow up is necessary to clarify the natural history of the disease.

Adolescent↗
PubMed1971

Breast involvement in Wegener's granulomatosis.

Two cases of Wegener's granulomatosis are described in which the early and predominating lesions were found in the breast. The histological features of breast necrosis with granulomatous inflammation and widespread vasculitis in the breast in the absence of any demonstrable pathogens enabled a presumptive diagnosis to be made in one case before the development of the more characteristic clinical features in the respiratory system.

Adult↗
PubMed1968

Nephrotic syndrom with heart disease: a reappraisal.

The evidence that heart failure alone may cause a nephrotic syndrome is inconclusive. Mercurial diuretics, which have also been implicated as a cause of the nephrotic syndrome, had been given in 23 of the 24 well-documented cases.Two cases of heart disease and nephrotic syndrome are described. Glomerular lesions were minimal on light microscopy, but thickening of the glomerular tuft basement membrane and partial fusion of the epithelial cell foot processes were apparent on elecronmicroscopy. The response to prednisone was such as to justify a trial of corticosteroid therapy in such cases despite the presence of cardiac disease.

Female↗
PubMed1968

Elastofibroma dorsi.

Two cases of elastofibroma dorsi are reported and the light and electron microscopic features analysed. The appearances suggest that the characteristic fibres and globules that stain as for elastin arise by denaturation of collagen. The fibres differ from the elastin of arterial wall, elastotic degeneration of skin, and pseudoxanthoma elasticum. The morphology and clinical behaviour indicate that elastofibroma dorsi is a reactive fibromatosis rather than a true neoplasm.

Arteries↗