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Biomedical subjects

J R Silva

Publications and source records attributed to J R Silva.

35 records · Page 2Linked to original sources
PubMed1990

Congenital dislocation of the knee.

Congenital dislocation of the knee (CDK), first described in 1922, is a rare condition sometimes associated with other congenital malformations. There is a total anterior dislocation with recurvatum and upward displacement of the proximal tibia. This review covers our ten year experience at the hospital San Juan de Dios, in Caracas, Venezuela, a children's hospital with three orthopaedic services. We have seen 22 affected knees in 14 patients. Newborn patients were treated on traction until reduction was achieved, followed by serial plaster of Paris casts until, optimally, 90 degrees of flexion was gained. Surgical treatment was used if conservative treatment had failed after six months, or if the patient first presented after the age of 12 months. All our patients were eventually able to walk, three with the assistance of calipers. Some limitation of knee flexion was commonly seen. The best results were achieved when treatment was started early.

Abnormalities, Multiple↗
PubMed1989

The immunological component of the cellular inflammatory infiltrate in bronchiectasis.

Immunohistological analysis of bronchial biopsy specimens from nine patients with bronchiectasis and four control subjects was performed with a panel of monoclonal antibodies selected to show lymphocyte and macrophage subsets and signs of cellular activation. The cells taking part in the inflammatory response in the bronchial wall of patients with bronchiectasis were almost exclusively mononuclear cells, most of them T lymphocytes. B lymphocytes were observed in biopsy specimens from only two out of nine patients. CD8+ T cells outnumbered CD4+ cells in all patients in a ratio ranging from 2:1 to 10:1. Most T lymphocytes also strongly expressed CD7 antigen and a proportion of them expressed HLA-DR. Most of the lymphocytic infiltration occurred just beneath the basement membrane of the epithelium, though intraepithelial and submucosal infiltration was also seen. Non-lymphoid mononuclear cells expressing the phenotype of dendritic cells and macrophages were found dispersed throughout the infiltrate, most of them expressing HLA-DR. These observations support the hypothesis that cell mediated immunological reactions contribute to the inflammation associated with bronchiectasis.

Adult↗
PubMed1989

The games we play.

Explore the source record for details and available documents.

Education, Nursing, Continuing↗
PubMed1984

The effect of experimental induced hypocalcaemia on uterine activity in the sow during parturition and post-partum.

Uterine activity was measured by monitoring intrauterine pressure changes using ballon-tipped catheters placed in the lumen. An infusion rate of Na(2)EDTA of 35 mg/Kg/h gave a chelation rate equivalent to the rate of calcium mobilisation, and when infused at a level greater than this, resulted in a reduction in plasma calcium concentrations and a concomitant reduction in uterine activity. In three of the four sows infused intrapartum, there was complete cessation of uterine activity; however, plasma calcium concentrations of less than 6 mg 100 ml resulted in a reduction in uterine activity at this stage of parturition. The uterus of the sow post-partum appeared to be more sensitive to the effects of hypocalcaemia with reduced uterine activity when plasma calcium concentrations fell below 8.2 mg 100 ml and complete cessation of activity between 6 and 7 mg 100 ml . Although there was evidence of a delay in the expulsion of piglets in the hypocalcaemic sows, there was no evidence of an increased number of stillborn piglets compared with the two control sows.

Journal Article↗
PubMed1983

Effect of a first-trial cue on spontaneous recovery by moderately mentally retarded adults.

The effect of a distinctive first-trial cue on the degree of spontaneous recovery of moderately mentally retarded adults was investigated. The group given the cue showed more recovery of the operant response than did control groups for disinhibition on unextinguished discriminative stimulus. The group receiving the conventional procedure to produce spontaneous recovery, however, displayed significantly greater recovery than did any of the other groups. There was thus limited support for the hypothesis that cues associated with the first trial of a training session have greater significance for learners than do other cues.

Adolescent↗
PubMedDate not supplied

Absorption of intra-bronchial diprophylline-methodology and preliminary results.

With the objective of measuring alveolo-capillary permeability, a diprophylline solution (molecular weight 254 D) was instilled as a bolus. Instillation was performed through distallized impacted fiber bronchoscope and 3 normal volunteers and 3 patients with pulmonary fibrosis were evaluated. Blood samples were collected at regular intervals with subsequent pharmacokinetic study, mainly aimed at determining absorption kinetics. This technique enabled us to distinguish the two groups of individuals which had different absorption rates. In controls, kinetics apparently followed a simple, one compartment model for absorption, which was slower and occurred to a lesser extent. Patients with a pulmonary fibrosis had a faster and higher degree of absorption, with a larger plasma Cmax. In the latter group two-compartment kinetics for absorption was found. We conclude that absorption kinetic parameters can disclose data on structural integrity of epithelia and possible lesions of the lung interstitium.

Absorption↗
PubMedDate not supplied

Experimental study of induced inflammation in the Brazilian Boa (Boa constrictor constrictor).

The objective of this work was to identify the cellular types present in inflammatory processes in the Brazilian snake, Boa constrictor constrictor. Blood smears were first made from three normal snakes and stained by several methods to identify the cell types present, thus facilitating the identification of cells in inflammatory processes induced in 16 further snakes by the subcutaneous implantation of cotton suture threads and circular coverslips. Implanted threads induced migration of heterophils and monocytes after 4 h, more intense monocyte migration after 24 h, an intense granulocytic migration inside and around the thread after 48 h, heterophilic granulocytes, macrophages and giant cells after 7 days, and giant cells with a typical granuloma response and persistence of heterophilic cells after 15, 69 and 117 days. The cell population attached to the implanted coverslips after 4 h was composed of heterophils, thrombocytes, erythrocytes and macrophages; after 24 and 48 h heterophils predominated, and after 7 days heterophils, macrophages and giant cells predominated.

Animals↗
PubMedDate not supplied

[Toxic effects and in vitro inefficacy of deltamethrin on larvae of Rhipicephalus sanguineus from Goiânia, Goiás, Brazil].

It has been observed that formulations of deltamethrin developed for disinsectization of infested places and control of parasitic arthropods of bovines and equines have frequently been used by breeders of dogs to control ticks in their animals and kennels, but without due consideration of the correct dosage or means of application. With the purpose of evaluating the efficacy of this product on Rhipicephalus sanguineus, bioassays were realized with larvae at 27+/-1 degrees C, UR>80% and light period of 12 hours. The mortality and toxicological effects were observed for 30 h, at 6 h intervals. Important toxicological effects were observed on the larvae, such as lack of co-ordination, knock-down and paralysis followed by death, although the lethal capacity of the product after 30 h was low, with mean mortality of only 34%, 40.2%, 46% and 57.6% respectively, for the 0.5 ml/l; 1 ml/l; 2 ml/l/; and 3 ml/l dosages. There was no mortality in the control group. The results obtained did not indicate the use of this formulation, in the tested dosages, as a method of choice for R. sanguineus control.

Animals↗
PubMedDate not supplied

[Epizootic outbreaks of trichinosis in 2 pig farms from the Metropolitan Region of Chile].

In Chile swine trichinosis has presented a progressive decreasing in the last two decades of XX century. T. spiralis pig infection descended from an average of 0.683 per 1000 in 1980-1984 to 0.315 in 1985-1989 and to 0.115 in 1990-1996. In the particular case of Metropolitan Region this decreasing has been more marked: from an average of 0.058 per 1000 in 1990-1994 to 0.003 in 1995-1999. Between the end of June 1999 and middle January 2000 in Metropolitan Region abattoirs T. spiralis was detected in 15 (4.9%) out of 306 swine from two pigsties located in El Monte (E.M.) and Padre Hurtado (P.H.) 45 and 30 km south-west from Santiago. In the same period another four pigs from the same premises were found infected in abattoirs of other regions. During inspection visits it was stated that both pig farms had deficient sanitary conditions. Phototrichinoscopy was positive in three out of five Rattus norvegicus collected in E.M. In pigsty PH the examination of diaphragm samples of 25 dogs and 17 cats resulted negative. In the premises originating T. spirali infected swine the Metropolitan Environmental Health Service Abattoirs Program carries out an epidemiological vigilance consisting in the follow-up of animals destined for slaughtering in order to initiate prophylactic actions oriented to eliminate eventual sources of trichinosis infection for human and rearing pigs.

Abattoirs↗