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J R Salvatore

Publications and source records attributed to J R Salvatore.

12 recordsLinked to original sources
PubMed1999

Pseudomesotheliomatous carcinoma involving pleura and peritoneum: A clinicopathologic and immunohistochemical study of three cases.

Pseudomesotheliomatous carcinoma is a rare variant of peripheral adenocarcinoma of the lung that can manifest clinical, radiologic, and pathologic features similar to malignant mesothelioma. We present three patients with pseudomesotheliomatous carcinoma of the lung. In one patient the carcinoma extended beyond the thorax and extensively involved the peritoneum, mesentery, omentum, and intestines. All patients experienced weight loss and chest pain. All were white men aged 63, 65, and 67 years. Two were smokers and had shortness of breath, cough, and pleural effusion. One had a history of asbestos exposure. No patient developed dyspnea or hemoptysis. One was successfully treated for prostatic carcinoma 18 months earlier. Radiographically, all tumors were pleura-based. Grossly, the tumors spread extensively over pleural (and in one case peritoneal) surfaces and mimicked malignant mesothelioma. Histologically, all tumors were poorly differentiated and necrotic; two tumors exhibited spindle-cell components and desmoplasia. Mucin production was detectable in none, 10%, and 50% of tumor cells. The percentages of tumor cells immunoreactive for Ber-EP4 were 70%, 100%, and 80%; for Leu MI 0%, 90%, and 50%; for epithelial membrane antigen 80%, 80%, and 100%; for B 72.3%, 0%, 90%, and 20%; for polyclonal carcinoembryonic antigen 0%, 10%, and 10%; and for monoclonal 5%, 0%, and 0%. Of these, Ber-EP4 and B 72.3 rendered the most reliable diagnostic results. The clinical, radiologic, and gross and routine histologic findings were similar to those of a malignant mesothelioma; the final diagnosis could be made based mainly on immunocytochemical results. We have reviewed the English and German literature regarding 65 such tumors and present our experience with three additional cases. We emphasize the application of immunocytochemical studies on pleura-based poorly or undifferentiated malignant tumors of unknown origin.

Aged↗
PubMed1999

Primary bilateral adrenal lymphoma.

Primary adrenal lymphoma is a rare primary neoplastic disease of the adrenal glands, with up to 65 cases reported in the literature over the past 40 years. The increasing use and sophistication of medical diagnostic imaging has allowed this disease to be diagnosed more frequently premortem, presenting more opportunity for treatment. The true incidence of these neoplasms is not known, nor is it clear why historical autopsy series have not reported this neoplasm more frequently, and why its existence has been documented more recently with advanced diagnostic imaging. This review has presented our new case, and reviewed 5 more in the literature, bringing the total number of cases to over 70. Accumulation of more cases and the experience treating these cases is needed to develop a better picture of diagnostic procedures and treatment regimens that have maximum efficacy.

Adrenal Gland Neoplasms↗
PubMed1996

Low-frequency magnetic fields and cancer. What you should know and what to tell your patients.

Although the available scientific data that low-frequency magnetic fields play a role in the etiology of cancer are inconclusive, this link has been suggested by epidemiologic data and proliferated in the nonscientific literature. Electric power lines, cellular phones, and personal computers are examples of sources that have been blamed for medical problems, particularly cancer. Since exposure to low-frequency magnetic fields is universal and practically unavoidable, what can physicians advise their patients? In light of the controversy surrounding this issue, the best advice may be to minimize such exposure. Future research on the health implications of low-frequency magnetic fields appears to be warranted.

Electromagnetic Fields↗
PubMed1996

Nonionizing electromagnetic fields and cancer: a review.

Low-frequency electromagnetic radiation had previously been thought to cause human injury only by generation of excess heat or by shock from direct contact with electric current. Information accumulating over the past few decades, however, suggests that nonionizing electric and magnetic fields associated with this radiation may be an environmental etiology in human disease. Human beings are affected not only by natural background nonionizing electromagnetic fields produced by the Earth, but also by a host of manmade sources. Of the diseases believed related to these fields, cancer and participation of these fields in the carcinogenic process have received considerable attention. This paper is a review of the basic science that points to this possible association.

Animals↗
PubMed1993

Radar guns.

Explore the source record for details and available documents.

Humans↗
PubMed1989

Non-ionizing electromagnetic radiation and cancer--is there a relationship?

A number of problems become evident when we attempt to assess the data in this review. We must first acknowledge the fact that EM radiation, as opposed to some chemical and physical pollutants which can be seen, tasted, or detected by odor, is in most situations not detected by human senses. This fact alone, however, does not prove or disprove the conjecture that EMR is a potential health hazard. The studies on the effects of EMR on cell systems, animals, and human subjects, report results which promote in some and reject in others the hypothesis that EMR in the ELF and microwave range is carcinogenic. Much of the criticism of the studies on human subjects centers around (1) quantifying exposure to EM Fields; (2) the epidemiologic-statistical methods used to gather, study, and interpret the data; and (3) lack of data studying co-carcinogens. Although there is no convincing evidence that EMR is carcinogenic, the uncertainty, in addition to the ubiquity of EMR, makes study of its possible health effects and its carcinogenic potential an essential part of future medical and epidemiologic research.

Animals↗
PubMedDate not supplied

Non-ionizing electromagnetic radiation: a study of carcinogenic and cancer treatment potential.

Non-ionizing electromagnetic radiation (NIEMR), particularly the magnetic field component, has been implicated in the development of human neoplasia. Research suggests that if these fields are part of the carcinogenic pathway, they may act as a promoter or in the progression of established cancer. Active progression of cancer cells by NIEMR negate the possible early detection of clinically silent neoplasms. We have observed the effect of non-ionizing electromagnetic fields on an established breast carcinoma cell line MCF-7, and found no stimulation of growth when exposed to a low-frequency magnetic field. The same magnetic field has been used as an adjuvant to anti-neoplastic chemotherapeutic agents. The results of this study have shown an improvement in the neoplastic cell kill by antineoplastic chemotherapy when coupled with a low frequency magnetic field. Non-ionizing electromagnetic radiation may be involved in the carcinogenic process; however, the answer to this question awaits further studies. We are exploring new methods of cancer treatment using non-ionizing electromagnetic radiation.

Animals↗