Search PubMed⌕ Search

Biomedical subjects

J R Neff

Publications and source records attributed to J R Neff.

At least 73 records · Page 4Linked to original sources
PubMed1991

Case report 695: Cementifying fibroma of the proximal end of the tibia.

A case of a cementifying fibroma in the proximal end of the tibia in a 31-year-old woman is presented. The lesion was expanding but well-defined with amorphous central calcification. The unique, calcified, cementum-like particles in a fibrous stroma have been reported in only four previous cases in long bones. The histological and radiographic differences between a cementifying fibroma, bone cysts with cementum, and a true cementoma are discussed. The radiological differential diagnosis of fibrous dysplasia, giant cell tumor, and low grade central osteosarcoma was considered.

Adult↗
PubMed1991

Significance of chromosomal abnormalities in a malignant giant cell tumor of bone.

Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX, -1, -11, +22,del(2)(p22),t(7;7) (p22;q32), +der(1)t(1;11;21)(p32;q13;q22), +der(19)t(19;?)(q13.4;?), der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.

Bone Neoplasms↗
PubMed1991

Ewing's sarcoma. Radiotherapy versus surgery for local control.

Significant strides in the treatment of Ewing's sarcoma, the second most common bone tumor of childhood, have resulted in cure for approximately 50% of patients. Successful therapy requires systemic chemotherapy for the eradication of microscopic or overt metastatic disease and surgery or irradiation therapy for control of the primary lesion. The article debates the controversy over the extent to which surgical resection should play a role in the local management of this disease.

Bone Neoplasms↗
PubMed1991

Survivorship analysis of VSP spine instrumentation in the treatment of thoracolumbar and lumbar burst fractures.

We used survivorship analysis to study 21 burst fractures that were treated with posterior VSP spine implant and fusion, each of which was over two motion segments. There were two treatment classes: 1) eight patients whose surgery included anterior bone grafting (augmentation), seven of which were done by the transpedicular approach; and 2) 13 patients whose surgery did not include anterior bone. Eight patients, seven of whom were in the second group, met at least one of the failure criteria. Life table calculations showed 100% implant survival through 22 months in the group treated with anterior bone augmentation, while the nonaugmented group showed 92% survival at 6 months, 68% survival at 9 months, 60% survival at 13 months, and 50% survival at 19 months. Statistical comparisons of the two groups resulted in P-values of 0.05 (Breslow) and 0.04 (Mantel-Cox). Based on this method of analysis, VSP instrumentation and two-level fusion is suitable surgical treatment for many burst fractures, but high failure rates may result if anterior bone augmentation is not performed.

Actuarial Analysis↗
PubMed1990

Cytogenetic analysis of dermatofibrosarcoma protuberans.

A case of dermatofibrosarcoma protuberans that occurred in an old burn scar over the anterior chest wall of a 46-year-old man is reported. Cytogenetic analysis of the tumor cells showed the presence of two abnormal clones: 47,XY, +8 and 48,XY, +8, +r.

Chromosome Aberrations↗
PubMed1990

Primary skeletal Ewing's sarcoma in Down syndrome.

Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.

Adolescent↗
PubMed1990

Cytogenetic findings and biologic behavior of giant cell tumors of bone.

Giant cell tumor of bone is a benign but often aggressive lesion with a distinct tendency toward local recurrence and, rarely, malignant transformation. Over a 3-year period, 20 giant cell tumors from 14 different patients were cytogenetically characterized. Random chromosomal abnormalities were detected in 14 of the 20 specimens and clonal chromosomal abnormalities were detected in six. An unusual anomaly, telomeric fusion, was the most striking random chromosomal abnormality detected. A comparison of the presence or absence of cytogenetic aberrations and the clinical behavior of these neoplasms was studied as well as a comparison of the aberrations in the initial specimen with those in subsequent specimens. Chromosomal abnormalities were detected in all but one of the ten tumors shown to be locally aggressive, recurrent, or metastatic. (The abnormalities observed in five of these tumors were clonal). There were no chromosomal abnormalities present in three of four tumors that behaved in an innocent fashion. These findings support the presence of chromosomal abnormalities in giant cell tumors (telomeric fusion in particular) and suggest that cytogenetic analysis may be useful in predicting the biologic behavior of these neoplasms.

Adolescent↗
PubMed1990

Chromosomal abnormalities in clear cell sarcoma. Implications for histogenesis.

Cytogenetic analysis was performed on three specimens of clear cell sarcoma, a rare neoplasm of uncertain histogenesis. Chromosomal analysis of clear cell sarcoma has not been reported previously. Two of the specimens analyzed consisted of the primary foot lesion and subsequent lymph node metastasis in a 29-year-old male. The other specimen was a primary foot lesion in a 61-year-old male. Clonal abnormalities were detected in all three of the specimens. The significance of these results with regard to the origin of this uncommon neoplasm is discussed.

Adult↗
PubMed1990

Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis.

Cytogenetic studies were performed on a malignant fibrous histiocytoma of bone and its metastasis to lung. Numerical chromosome abnormalities were described for all chromosomes except chromosomes 2, 4 and 16. Structural abnormalities in the primary tumor involved chromosomes 1, 3, 5, 10, 11, 13, 15, 16 and 17. The chromosomal rearrangements seen both in the primary tumor and its metastasis involved chromosomes 13, 15 and 17. Two X chromosomes contained large homogeneously staining regions (HSRs) in the primary tumor which were replaced by multiple double minutes (DMs) in the metastatic tumor.

Bone Neoplasms↗
PubMed1989

Postburn heterotopic ossification: insights for management decision making.

An analysis of 1,478 consecutive admissions to the University of Kansas Burnett Burn Center revealed 18 patients who developed heterotopic ossification (1.2% incidence). Seventeen patients developed this disease in the elbows; one patient had shoulder involvement. Two patients eventually developed bilateral elbow disease. All patients initially presented with pain and limitation of joint motion. The diagnosis was then confirmed radiographically. All patients suspected of heterotopic ossification received physical therapy consisting of active range of motion only. Ten patients responded to conservative treatment and regained functional range of motion, and eight patients developed refractory ankylosis requiring surgical management. All surgically managed patients achieved a functional range of motion with an average followup of 35.0 months.

Adult↗
PubMed1989

Desmoplastic fibroma arising in fibrous dysplasia. Chromosomal analysis and review of the literature.

A desmoplastic fibroma of bone arose in the fibula of a 17-year-old boy with fibrous dysplasia. This may be the second case of this rare histopathologic association reported in the literature. Benign bone tumors have not previously been subjected to cytogenetic analysis. Analysis of this case revealed a primary abnormal clone trisomic for both chromosomes 3 and 5 and two subclones, one trisomic for chromosome 3 and one trisomic for chromosome 5. This case may also present the first description of nonrandom karyotypic abnormalities in a benign neoplasm of bone.

Adolescent↗
PubMed1987

Ankylosing spondylitis presenting as juxta-articular masses in females.

Juxta-articular inflammatory masses, sternomanubrial or sternoclavicular, were noted in two women who were subsequently found to have ankylosing spondylitis. The differential diagnosis of juxta-articular masses should include systemic rheumatic disorders as well as tumor or infection.

Adult↗