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Biomedical subjects

J R Miliauskas

Publications and source records attributed to J R Miliauskas.

At least 19 recordsLinked to original sources
PubMed1995

Granulomatous lobular mastitis.

Two cases of benign lobular granulomatous mastitis, both clinically felt to be carcinoma, are reported. One patient was cured by local excision of the mass while the other was cured by oral prednisolone, demonstrating the variable ways to treat this entity. The clinical and histological features were similar to those noted in previous reports. Immunological studies revealed predominantly stromal T lymphocytes and only duct intra-epithelial T lymphocytes.

Administration, Oral↗
PubMed1994

Tissue response to artificial hormone replacement implant.

The histological changes relating to 2 separate artificial hormone replacement implants in a 34 yr old female are presented. Both sites essentially showed a predominant lymphohistiocytic reaction with fibrosis. One implant was intact while the other had disintegrated.

Adult↗
PubMed1993

Intra-abdominal desmoplastic small round cell tumour.

Intra-abdominal desmoplastic small round cell tumour is a rare tumour which has only recently been described. It demonstrates epithelial, mesenchymal and neural features and has an aggressive clinical course. We report a case of a 15 year old male with this tumour who, after debulking surgery and chemotherapy, relapsed with disease 1 month later. After further debulking surgery, extensive chemotherapy and bone marrow transplantation he relapsed with disease 5 months later and died. Total survival was 20 months.

Abdominal Neoplasms↗
PubMed1993

Postimmunization (vaccination) injection-site reactions. A report of four cases and review of the literature.

Four patients each had a single subcutaneous nodule at the site of a previous vaccine injection; three after injection of diphtheria, tetanus, and pertussis vaccination and one after tetanus toxoid vaccination. Presentation was with a mass 4-22 months after vaccination at the site of injection. Histologically, three patients had a necrotizing granulomatous reaction with a surrounding infiltrate of lymphocytes, plasma cells, histiocytes, and associated fibrosis. The fourth patient demonstrated a lymphohistiocytic reaction with a predominance of histiocytic cells as well as associated plasma cells, fibroblasts, and fibrosis. The lymphoid infiltration in these reactions showed a predominance of T-lymphocytes over B-lymphocytes. Aluminum was demonstrated in necrotic foci, inflammatory stroma, and the granular cytoplasm of histiocytes with the aid of solochrome azurine and solochrome cyanine stains as well as by energy-dispersive x-ray microanalysis. The reactions are thought to be immunologic (hypersensitivity) reactions associated with the aluminum contents of the preparation.

Adolescent↗
PubMed1992

Small cell (neuroendocrine) carcinoma of the vagina.

We report a case of vaginal small cell (neuroendocrine) carcinoma. Immunostaining for neuron-specific enolase, PGP 9.5, chromogranin, synaptophysin, Leu 7 and cytokeratin was positive. Neurosecretory granules were found by electronmicroscopy. There was local recurrence and regional lymph node metastases. The patient survived for 10 months following local surgical therapy only.

Aged↗
PubMed1991

Localized herpes simplex lymphadenitis: report of three cases and review of the literature.

This report describes three cases of localized or regional herpes simplex virus lymphadenitis. Of the two patients who presented with inguinal lymphadenopathy, one had a localized rash prior to the development of lymphadenopathy, and the other developed a genital rash 2 days after lymph node biopsy. The third had occipital lymphadenopathy and concurrent localized occipital herpetic folliculitis. Localized herpes simplex virus lymphadenitis appears to be a specific clinicopathological entity. Histologically, it is characterized by varying degrees of follicular and paracortical hyperplasia, a prominent immunoblastic response and perinodal inflammation. Viral inclusions with or without focal necrosis in the lymph node may be seen, and immunostaining for viral antigen may be seen in paracortical cells.

Adult↗
PubMed1991

Carcinoid tumor occurring in a mature testicular teratoma.

A rare case of a primary testicular carcinoid tumor, occurring in a mature teratoma from a 33 year old man, was examined histochemically, immunohistochemically and by electron microscopy. Both argyrophil and argentaffin reactions were positive. Immunoreactive cells for 5-hydroxytryptamine (5-HT) and gastrin were present. Electron microscopy demonstrated neurosecretory-type granules. The English literature was reviewed and this revealed at least 6 similar cases.

Adult↗
PubMed1991

Adenoid cystic carcinoma in a juvenile male breast.

Adenoid cystic carcinoma of the breast is uncommon and comprises less than 1% of all mammary cancers. Its occurrence in the male breast is very rare. We describe the first case of adenoid cystic carcinoma in a juvenile male breast. The patient is alive and well 2 1/2 yrs following subcutaneous mastectomy. The details of the 4 previously reported cases of the same tumor in male breasts are reviewed.

Adolescent↗
PubMed1986

Right-sided diverticular disease of the colon: a morphological analysis of 16 cases.

Right-sided diverticular disease is uncommon and represents a heterogeneous group of cases with varying clinical presentation often confused with other disorders. Based on number, size, distribution and histological appearance of the diverticula, four distinct groups were identified, each with a distinct clinical presentation. Six patients had solitary false diverticula mimicking acute appendicitis and at operation were found to have inflamed caecal masses. Five patients had diverticula formed on the basis of defects in the muscularis propria. The mean age of these patients was 30 years older than the previous group and all of them presented with rectal haemorrhage, often confused with angiodysplasia clinically. At laparotomy the external appearance of the bowel was unremarkable. Three patients had diverticular disease similar to that seen in the left side of colon. Two patients had true congenital caecal diverticula confirming that the minority of caecal diverticula conforms to this group.

Acute Disease↗
PubMed1986

Dermal monocytic sarcoma/monoblastic tumour: report of two cases of acute monocytic leukemia with initial dermal manifestations only.

The clinical and pathological findings in 2 patients with acute monocytic leukemia (AMOL) presenting initially as multiple monoblastic tumours of the skin (monocytic sarcoma) were reviewed. The skin biopsies were originally interpreted as malignant lymphoma and the diagnosis of AMOL was established when overt bone marrow and/or peripheral blood involvement was detected. The time interval from initial skin biopsy to either blood or bone marrow involvement by AMOL was 2 and 18 mth. After diagnosis of extracutaneous dissemination, survival was less than 1 mth. Cytochemistry, immunohistochemistry and electron microscopy can aid in the diagnosis of a monocytic sarcoma. Generally, the most practical way to confirm the diagnosis, in everyday practice, on fixed paraffin-embedded tissues is the demonstration of alpha-1-antitrypsin (A1AT) and/or lysozyme by the immunoperoxidase technique.

Aged↗