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Biomedical subjects

J R Kirkpatrick

Publications and source records attributed to J R Kirkpatrick.

At least 73 records · Page 4Linked to original sources
PubMed1973

Effects of dietary supplements of wheat bran and cellulose on faeces and bowel function.

In a study of bowel function in normal subjects wheat bran or cellulose was added to the diet for four weeks (16 g/day). Stool weight increased. Intestinal transit time did not significantly alter. Faecal bile acids did not increase but were diluted. It seems that the effect of these materials is to produce a bulky stool and that any symptomatic benefit they produce is secondary to this.

Adult↗
PubMed1973

Lysine biosynthesis in Streptomyces lipmanii: implications in antibiotic biosynthesis.

Streptomyces lipmanii produces two beta-lactam antibiotics, penicillin N and 7-(5-amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid. Both antibiotics contain alpha-aminoadipic acid side chains. In similar antibiotics produced by certain fungi, the alpha-aminoadipoyl moiety is derived from an intermediate in lysine biosynthesis. Our findings indicate, however, that in S. lipmanii, lysine is synthesized via alpha, epsilon-diaminopimelic acid-an entirely different biosynthetic route. This finding suggests not only a unique mechanism for the derivation of alpha-aminoadipate, but also that the system may be particularly amenable to genetic manipulation.

Amino Acids, Diamino↗
PubMed1973

The gastric secretory response to a continuous insulin infusion in the dog.

The gastric acid response to graded doses of insulin given by continuous infusion was studied in four dogs, each surgically provided with a gastric fistula. All doses of insulin resulted in a prolonged plateau of hypoglycaemia and the degree of hypoglycaemia correlated significantly (p <0.05) with the insulin dose, up to 0.15 u/kg hr. Similarly, graded doses of insulin (up to 0.15 u/kg hr) produced graded acid responses and both the peak acid output and the total acid output correlated significantly with blood glucose changes. No initial inhibitory phase of acid secretion followed the start of the infusion, but a dose-related delay in the onset of the acid response was observed. Our results indicate that insulin provides a quantitative glycopenic stimulus producing a quantitative vagal acid response.

Animals↗
PubMed1972

Insulin infusion test of gastric acid secretion.

In view of the disadvantages of the standard insulin test for completeness of vagotomy a continuous insulin infusion test has been developed. Twenty-six tests were carried out on 12 healthy male volunteers. A dose of 0.04 unit of soluble insulin/kg/hr was found to produce the highest acid secretion with the least severity of symptoms of hypoglycaemia. The pattern of response was a plateau of acid secretion and of hypoglycaemia, and repeated studies in six subjects showed that the results were reproducible. Evaluation of this test after vagotomy and comparison with the standard insulin test are now required.

Adult↗