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Biomedical subjects

J R Jones

Publications and source records attributed to J R Jones.

143 records · Page 8Linked to original sources
PubMedDate not supplied

Changes in injection-site blood flow and plasma free insulin concentrations in response to stress in type 1 diabetic patients.

In order to test the effect of stress on injection-site blood flow and blood glucose control, 16 C-peptide negative patients were studied on a stress day, when a 30-min Stroop Colour-Word Test was completed, and a control day, when a cartoon was shown. Unmodified insulin was injected subcutaneously into the thigh before the test, and injection-site blood flow measured throughout the experiment with a thermal clearance probe. Blood glucose and plasma free insulin, glucagon, growth hormone, cortisol, and catecholamines were measured at intervals before, during, and after stress. Patients showed a significant overall rise in injection-site blood flow with the Stroop test from 4.1 (SD 1.6) to 5.2 (1.8) ml 100-g-1 min-1 (increase 38.1 (37.8) %, p less than 0.001). There was no overall significant difference between stress and control days in blood glucose or plasma free insulin levels, with differences in mean blood glucose levels during stress between the 2 days varying from -4.2 mmol l-1 to +6.3 mmol l-1 in individual patients. The increase in injection-site blood flow with stress correlated significantly with the increase in plasma free insulin concentration both during (r = 0.55) and after stress (r = 0.71). Differences in blood glucose concentration between stress and control day for each patient showed strong correlation with differences in plasma free insulin both during (r = -0.73) and after stress (r = -0.79). Differences in counter-regulatory hormones occurred but correlated poorly with blood glucose difference. Thus, stress affects the blood flow at the injection site, and this in turn affects insulin absorption. Most of the blood glucose response to stress is explained by changes in free insulin concentration.

Adult↗
PubMedDate not supplied

A study of the communicating branch between the medial and lateral plantar nerves.

A study of the communicating branch between the medial and lateral plantar nerves was carried out on the feet of 20 cadavers. The nerve was found to be present in all the feet examined, but in two women it was considerably enlarged bilaterally. It is suggested that this enlarged communicating branch may be a factor responsible for the frequent involvement of the nerve to the third interspace by Morton's neuroma.

Cadaver↗
PubMedDate not supplied

Technology's role in a new health care system.

Employers that will prosper under a revamped health care system will be those that plan and lobby for redesign of medical and flexible benefits and equip themselves with advanced technology to manage reform changes.

Health Benefit Plans, Employee↗
PubMedDate not supplied

Development and learning in the offspring of rats fed an alcohol diet on a short- or long-term basis.

The offspring of rats fed a diet containing 12.5% (v/v) ethanol prior to, and during, gestation (LTE) were compared to the offspring of rats fed the same diet during gestation only (STE) in three studies. In Study I the neonates were tested on a variety of neuroreflex tasks, in Study II the offspring were tested in an activity wheel and open field, and in Study III the offspring were trained in a runway under partial or consistent reward conditions. Results indicated that STE offspring were delayed in developing fur and in opening their eyes, they righted more rapidly, and were slower in developing a reaction to and habituating to an auditory stimulus than their controls (STC) and the LTE offspring. Generally, movement was greater for ethanol exposed offspring and the LTE offspring showed more persistent fear-related responses than the STE offspring. No statistically reliable differences in learning or extinction were found among the groups, although a trend towards better learning and less resistance to extinction was noted in the LTE animals. Long-term alcohol use seems to attenuate the effects of gestational alcohol in rats.

Animals↗