Biomedical subjects
Publications and source records attributed to J R Hessler.
Several methods for external sampling of blood and administration of intravascular fluids are applicable to reptilian species. This paper reviewed some of the technics that have been previously reported and introduced several new procedures applicable to snakes, turtles, alligators, crocodiles, and lizards.
A newly recognized neurologic disorder of cats is described. It is characterized clinically by an abnormal coat color and development of progressive ataxia during infancy. Breeding experiments indicate that the disease is inherited in an autosomal recessive manner. Pathologically, neurologic lesions closely resemble those described in infantile neuroaxonal dystrophy of children. The most prominent microscopic alterations were marked ballooning of nerve cell processes within specific regions of the brain stem and atrophy of the cerebellar vermis. Ultrastructural studies demonstrated that dystrophic axons contained electron-dense flocculent material, multilaminated membrane-bound osmiophilic bodies and filaments. Examination of the inner ears revealed depletion of neurons in the spiral ganglia and homogeneous eosinophilic bodies within the spiral ganglia, nerve fiber tracts and organ of Corti. The concept that the disease represents an inborn error of metabolism was supported by finding axonal dystrophy in neonates prior to development of cerebellar atrophy or recognition of clinical symptoms.
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The results of this study indicate that when human VLDL or LDL is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can be predicted by assaying for the presence of thiobarbituric acid-reacting substances on the lipoprotein. However, malondialdehyde, which reacts with thiobarbituric acid and is known to be injurious to cells, was not cytotoxic in the same experimental system when dissolved in culture medium or covalently bound to non-toxic LDL. The toxic agent(s) on oxidized LDL is(are) located in a lipid-extractable moiety. Since lipid peroxides and oxidized sterols can occur in vivo under various pathological conditions, the cytotoxicity of these lipoprotein-associated substances observed in vitro may be related to certain manifestations of these conditions.