Biomedical subjects

J R Hartmann

Publications and source records attributed to J R Hartmann.

At least 37 records · Page 2Linked to original sources

PubMed1977

Chemotactic activity in the coronary sinus after experimental myocardial infarction: effects of pharmacologic interventions on ischemic injury.

Various pharmacologic interventions that suppressed chemotactic factor activity in the coronary sinus after acute ischemia were analyzed for protective effects on myocardium. Ischemic injury was determined by comparing the slopes of the regression lines derived from 24 hour myocardial creatine kinase content versus S-T segment elevation 15 minutes after coronary ligation. Dogs treated 30 minutes after ligation with cobra venom factor, hydrocortisone or Trasylol showed a marked decrease in chemotactic activity in the coronary sinus. These agents also showed a protective effect on ischemic injury when compared to control. Myocardial biopsy specimens from areas of significant ischemia defined by S-T segment elevations in dogs treated with cobra venom factor were essentially devoid of an inflammatory response whereas those from dogs treated with Trasylol or hydrocortisone showed moderate neutrophil infiltration and minimal tissue exudate.

Animals↗

PubMed1976

Marrow transplantation in treatment of children with aplastic anaemia or acute leukaemia.

Seventy-six patients, aged 2 to 17 years, were treated with bone marrow transplantation for severe aplastic anaemia or acute leukaemia refractory to conventional therapy. 16 of the 22 patients (73%) who received marrow transplantations for aplastic anaemia are surviving, 12 of these for over one year. In acute leukaemia, using preparation with cyclophosphamide and total body irradiation, 8 of 33 patients (24%) receiving allogeneic and 5 of 8 (63%) receiving syngeneic transplantations are continuing in remission from 3 months to beyond 2 years. The longest continuing remission off therapy is now over 4 1/2 years after preparation with total body irradiation. The major causes of failure remain graft-versus-host disease, infection, graft rejection (aplastic anaemia), and leukaemic relapse.

Adolescent↗

PubMed1975

Leukemia in childhood: introduction and etiology.

Striking improvement in the treatment of certain childhood cancers during the past decade has resulted from a combined multidisciplinary approach utilizing surgery, irradiation, and chemotherapy early in the disease process. Early use of long-term combination chemotherapy following deficitive clinical and hematologic staging has resulted in significant "cure" rates in several diseases. The etiology of childhood leukemia remains unknown. Implicated have been viruses, genetic abnormalities leading to increased susceptibility, exposure to various chemicals, and at times obscure hereditary or familial factors. The recurrence of leukemia in donor cells in a leukemic child following bone marrow transplantation is reported for the second time.

Adolescent↗

PubMed1974