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Biomedical subjects

J R Hardy

Publications and source records attributed to J R Hardy.

61 records · Page 4Linked to original sources
PubMed1987

The treatment of advanced recurrent carcinoma of the uterine cervix with platinum based cytotoxic chemotherapy.

Nineteen patients with advanced recurrent carcinoma of the uterine cervix received platinum based chemotherapy between February 1982 and April 1984. All patients had received prior pelvic irradiation. Eleven patients received combination chemotherapy with platinum, vinblastine and bleomycin (PVB), and 8 patients received a regimen of platinum and 5-fluorouracil (PF). Two patients achieved a complete response and 4 patients achieved a partial response, a total response rate of 33%. Five out of 6 responders received PVB. The median survival (MS) was 8 months (1-38) months from the first treatment with cytotoxic chemotherapy. In those patients achieving a response, MS was 13.5 months (6-38+ months) with 1 patient alive at 38 months, compared to an MS of 5 months (1-15 months) in those patients without response. Toxicity was significant with nausea and vomiting in the majority of patients. Two patients refused treatment after the first course because of toxicity. The morbidity of treatment was such that despite an encouraging response rate, particularly to PVB (45%), the routine use of such treatment must be questioned.

Adolescent↗
PubMed1985

[Posterior arthrodeses of the upper cervical spine in children and adolescents. Apropos of 19 cases].

The authors have analysed 19 cases of cervical spine fusion in children and teenagers with a review of the literature. In the present series, the levels fused were between the occiput, C1 and C2. The ages of the patients ranged between 2 months and 18 years. There was a great variety of indications for these operations, the majority being congenital deformities or Morquio's disease. The main disabilities were neurological impairment, or instability or deformity of the neck. Recent advances in radiological investigation made it possible to make a more precise diagnosis of lesions with bony deformities, fibrous bands or instability. In 9 instances, a fusion alone was made and in 10 it was associated with cord decompression. The results were analysed in relation to the clinical features, the post-operative mobility of the neck and the incorporation of the graft.

Adolescent↗
PubMed1984

Traumatic ligamentous instability of the cervical spine in children.

Sixteen cases of dislocation and ligamentous disruptions of the cervical spine in children are reported. In five cases resulting from injury to the upper cervical spine, the roentgenographical features of the instability at the C1-C2 level are documented and their therapeutic orientation is defined. Eleven injuries were of the lower cervical spine: three dislocations, two of which were old cases, and eight serious ligamentous disruptions. Diagnosis of serious ligamentous disruptions was based on precise radiographic criteria: increase of the interspinous distance, loss of parallelism between the articular processes, and posterior widening of the disc space. The indications for surgical fixations in serious ligamentous disruptions depend on persistence of the clinical and radiological signs after a long orthopedic immobilization.

Adolescent↗
PubMed1984

Roentgenographical study of the stability of the cervical spine in children.

A roentgenographical study of the supposedly normal cervical spine in 40 children is reported. At the upper cervical level, the validity of the criteria in the literature (especially the atlantodental distance on the lateral view) was confirmed, and an upper limit was determined for children. A study of the atlantoaxial relationship on the anteroposterior view in neutral position and in lateral position was performed. At the lower cervical level, measurements according to Penning (Am J Roentgenol 1978;30:317-26) and Cattel and Filtzer (J Bone Joint Surg [Am] 1965;47:1295-308) were applied to children and compared level by level at each age. This study allows a better comprehension of the mobility of the cervical spine in children and offers an explanation for suspicious roentgenographical features after trauma.

Adolescent↗
PubMed1979

An uncemented total hip replacement: experimental study and review of 300 madreporique arthroplasties.

Mafreporique arthroplasty is not intended as a bustitute for acrylic cement stabilized arthroplasty but is available as an effective alternative. An experimental and clinical investigation including radiological analysis of 300 madreporique arthroplasties has convinced us of the reality and reliability of biological anchoring by endosteal osteogenesis. The madreporique method does not result in any local or general complications usually associated with the cement technique. Full weight-bearing is permitted at the same postoperative time as the cemented prosthesis. The results at early and interim follow-up periods compare favorably with cemented hip arthroplasties. Living bone that undergoes remodelling provides for long-term anchor of the prosthesis and eliminates the chemical intermediary which leads, more or less, with time to loosening of the implant in a significant number of cases.

Aged↗