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Biomedical subjects

J R Goellner

Publications and source records attributed to J R Goellner.

At least 127 records · Page 7Linked to original sources
PubMed1980

Breast cancer incidence, prevalence, mortality, and survivorship in Rochester, Minnesota, 1935 to 1974.

The epidemiologic features of breast cancer in Rochester, Minnesota, were studied over the 40-year period 1935 to 1974. During this time, the age-adjusted incidence rate increased 25% to 82.7 per 100,000 person-years. Most of the increase occurred among women 45 to 64 years of age. Overall, the incidence of breast cancer increased with advancing age, as did breast cancer prevalence, which was 901.4 per 100,000 women on Jan. 1, 1975. Age-adjusted mortality rates declined slightly from 24.9 to 23.3 per 100,000 person-years during the study period. Survival after the diagnosis of breast cancer seemed to improve somewhat among women who were less than 45 or more than 65 years old at the time of diagnosis. This was associated with a decline in the proportion of these women with regional lymph node involvement or distant metastases present at the time of initial diagnosis.

Adenocarcinoma↗
PubMed1978

Bilateral massive nephroblastomatosis in infancy.

This report describes an infant with bilateral diffuse nephroblastomatosis, illustrating the typical clinical and pathologic characteristics that allow it to be differentiated from true bilateral Wilms' tumor.

Diagnosis, Differential↗
PubMed1978

Giant cell tumor of tendon sheath and pigmented villonodular synovitis: an ultrastructural study.

The ultrastructures of five examples of giant cell tumors of the tendon sheath and one example of pigmented villonodular synovitis were studied. The giant cell tumors were composed mostly of A and B types of synovial cells. Also present were fibroblastic cells with intracytoplasmic filaments with densities (myofibroblasts) as well as "monocytic" and "lymphocytic" cells. The giant cells seemingly were derived from the fusion of synovial cells of A type, whereas foam cells were derived from both A and B cells. Both the giant cell tumors and the pigmented synovitis are considered to be reactive and borderline proliferative lesions of the synovial cells.

Cytoplasm↗
PubMed1978

Malignant fibrous histiocytoma: an ultrastructural study of six cases.

The ultrastructures of six malignant fibrous histiocytomas were studied. The lesions were composed of different proportions of fibroblastic- and histiocytic-appearing cells. Intermediate, undifferentiated, and foam cells also were present. Three of the lesions had some "fibroblasts" that had intracytoplasmic bundles of filaments with focal densities (myofibroblastic cells). Malignant fibrous histiocytoma is considered a sarcoma that has an undifferentiated mesenchymal cell origin, that differentiates along a broad fibroblastic and histiocytic (fibrohistiocytic) spectrum, and that usually has a predominant "fibroblastic" component.

Abdominal Neoplasms↗
PubMed1978

Histogenesis of dermatofibrosarcoma protuberans. An ultrastructural study.

Ultrastructural study of five typical lesions of dermatofibrosarcoma protuberans revealed that the basic cell is fusiform and has a somewhat indented nucleus and an even distribution of cytoplasmic organelles. Fragments of basal lamina, intercellular junctions, abundant intercellular fibers, and a tendency to form cellular sheaths also were found. The tumor cells had a strong resemblance to pericytes and perineural cells, as well as marked ultrastructural similarities to neurofibroma. The authors conclude that dermatofibrosarcoma protuberans arises from a primitive fibroblastic cell with a "sheath forming cell" differentiation that has a closer relationship to the perineural cell than to the pericyte.

Fibrosarcoma↗
PubMed1978

Hemangiopericytoma of the meninges. Mayo Clinic experience.

A study of 26 hemangiopericytomas of the meninges revealed that the histologic appearance--including ultrastructural features--was similar to that of hemangiopericytomas of soft tissues. Both sexes were affected, and occurrence was most frequent in the adult years, with no symptoms specific for the lesions. The lesions were characterized by an aggressive course, with recurrence in 80% of the patients, and metastases in 23%; thus, the importance of recognizing the lesion pathologically is emphasized.

Adolescent↗
PubMed1978

Giant lymph node hyperplasia resembling abdominal abscess on gallium scan.

A case of giant lymph node hyperplasia with systemic symptoms resembling chronic infection is described which showed intense gallium uptake indistinguishable from uptake seen in an abscess. This rare syndrome may mimic an abdominal abscess and should be considered in the differential diagnosis of patients without prior history of abdominal surgery and in whom an abdominal abscess is suspected. The condition is relatively benign.

Abdomen↗
PubMed1977

Malignant giant cell tumor of soft parts. An ultrastructural study of four cases.

Four cases of malignant giant cell tumor of soft parts (MGCT) were studied ultrastructurally. Most of the cells in three cases were identified as undifferentiated mesenchymal cells and mononuclear monohistiocytic cells. The osteoclastlike cells seemed to arise from fusion of monohistiocytic cells. Immature fibroblastic cells, occasionally containing filaments with densities, were also present. They were scarce in three cases and predominant in the fourth. It was concluded that MGCT is a mesenchymal sarcoma with a bimorphic--monohistiocytic and fibroblastic--differentiation. MGCT is therefore considered a special variant of malignant fibrous histiocytoma.

Endoplasmic Reticulum↗
PubMed1977

Atypical fibroxanthoma of the skin: an ultrastructural study of two cases.

The ultrastructure of two atypical" fibroxanthomas of the skin was studied. The first lesion was a spindle cell tumor on light microscopy, which electron microscopy revealed was composed of undifferentiated mesenchymal cells. The second lesion had a highly pheomorphic appearance on both light and electron microscopy. It was formed by atypical histiocytic cells and abundant "typical" Langerhans cells. The second lesion was considered to be a proliferation either of atypical Langerhans cells or of histiocytes related to Langerhans cells. Thus, atypical fibroxanthoma of skin may not be a homogeneous entity but could be a group of mesenchymal proliferative lesion in a similar clinical setting.

Aged↗
PubMed1976

Carcinoma of the cervix. Clinicopathologic correlation of 196 cases.

One hundred ninety-six cases of patients with invasive squamous carcinoma of the cervix treated at the Mayo Clinic from 1960 to 1970 were evaluated for survival. All patients had been followed for at least five years; treatment was surgical, irradiation, or a combination of the two. The probability of survival was compared with grade and histologic type, with clinical staging taken into consideration. No significant difference in prognoses was found between grades or histologic type of tumors within any stage. As expected, advanced stages were associated with poorer survival rates than localized disease. Within patients who had Stage 1 disease, metastatically involved lymph nodes did not significantly diminish the probability of survival.

Adult↗
PubMed1975

Sertoli cell tumor: case report with ultrastructural findings.

In this case of Sertoli cell tumor of the testis, no laboratory or clinical evidence of hormonal imbalance was present. The histologic and ultrastructure characteristic of the tumor agreed closely with previous reports on these rare tumors of the gonadal stroma.

Adult↗
PubMedDate not supplied

Metastatic papillary cancer of the neck: a diagnostic dilemma.

The finding of papillary carcinoma in a neck mass usually leads to the presumptive diagnosis of metastatic thyroid carcinoma, with total thyroidectomy revealing the primary tumor. We report five cases of metastatic papillary carcinoma of the neck. The primary tumor in three of the cases was found to be nonthyroidal; two being discovered only after thyroidectomy failed to reveal a primary cancer. In the two thyroidal neoplasms, pathologic examination of the thyroid demonstrated only minimal tumor in one case and no detectable tumor in the other. These cases illustrate the pitfalls of diagnosis and treatment of these tumors and the utility of antithyroglobulin immunostaining in such cases.

Adenocarcinoma↗
PubMedDate not supplied

Diagnostic and prognostic utility of flow cytometric DNA measurements in follicular thyroid tumors.

Distinguishing cellular follicular adenomas (FA) from minimally invasive follicular carcinomas (FC) continues to plague even experienced thyroid pathologists. DNA ploidy analysis has been promoted as a means of making this differentiation; however, the finding of DNA aneuploidy in FA has caused concern that they may demonstrate potential for malignant behavior or should even be reclassified as low-grade noninvasive cancers. In histologically-proven FC, nuclear DNA content has been claimed to have predictive power equivalent to that of all other prognostic factors combined. The aims of the present study, therefore, were to define the DNA ploidy characteristics of FA and FC, to assess the diagnostic potential of cell-cycle parameters, and, in FC, to investigate the prognostic role of such measurements. We measured DNA content of 124 tumors (60 FA, 64 FC). DNA pattern was normal (diploid) in 75% of FA and 45% of FC, tetraploid/polyploid (T/P) in 13% of FA and 25% of FC, and aneuploid in 12% of FA and 30% of FC. FC was histologically verified in 39% of DNA normal, 67% of T/P, and 73% of aneuploid tumors. DNA index, S-phase, G2M, and S-phase plus G2M were analyzed and were not helpful in differentiating between FA and FC. No patient with FA developed tumor recurrence. In FC (excluding the Hürthle cell variant), no significant differences were found among the 3 DNA ploidy groups with respect to either cancer death or tumor recurrence; however, combining the Hürthle cell variant of follicular carcinomas with pure follicular carcinomas, the presence of distant metastases, DNA aneuploidy, and patient age were the only independently significant prognostic variables.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMedDate not supplied

Hürthle cell (oxyphilic) papillary thyroid carcinoma: a variant with more aggressive biologic behavior.

The latest World Health Organization International Classification defines papillary thyroid carcinoma by its "follicular cell differentiation...as well as characteristic nuclear changes". However the oxyphilic (Hürthle cell) papillary carcinoma have nuclei which generally resemble the nuclei seen in oxyphilic follicular carcinomas, and such oxyphilic papillary tumors may behave more aggressively than typical papillary cancers. To further characterize these rare tumors, we identified during a 32-year period 22 patients with oxyphilic papillary cancer and compared them with 1,084 patients with typical papillary cancers and 57 patients with oxyphilic follicular cancers treated by the Mayo surgical group during the same time period. Although typical papillary and oxyphilic papillary cancers were comparable with regards to patient age, tumor size and extent, TNM stage, and prognostic score (AGES), there were significant differences. Compared to typical papillary tumors, oxyphilic papillary cancers had fewer neck nodal metastases at primary diagnosis (5% vs 40%, p less than 0.0001), were more often DNA non-diploid (71% vs 21%, p less than 0.001), and after 10 postoperative years had higher rates of both tumor recurrence (28% vs 11%, p less than 0.0001) and cause-specific mortality (1.7% vs 4%, p less than 0.0005). In these four important respects the oxyphilic papillary cancers more resembled the oxyphilic follicular cancers. For oxyphilic follicular cancers, the frequency of initial neck nodal metastases was 7% (cf 5%); 83% of the oxyphilic follicular tumors were non-diploid (cf 71%), and at 10 years postoperatively the tumor recurrence and cause-specific mortality rates were 28% and 18%, insignificantly different from 28% and 17% seen with the oxyphilic papillary cancers.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Upper aerodigestive tract manifestations of Behçet's disease: review of 30 cases.

Behçet's disease is a chronic inflammatory disorder of undetermined cause. The most frequent manifestations are aphthous ulceration of the upper aerodigestive tract, genital ulcers, ocular inflammation, and arthritis. Less frequent features include involvement of the CNS, thrombophlebitis, and large-vessel arteritis. Of utmost importance is the fact that aphthous ulceration of the upper aerodigestive tract will develop in all patients who have Behçet's disease; thus, they may come to the otorhinolaryngologist for evaluation. This disease must be distinguished from recurrent aphthous ulceration, herpes simplex infection, Stevens-Johnson syndrome, Reiter's disease, pemphigus, systemic lupus erythematosus, and Crohn's disease. Behçet's disease is diagnosed on the basis of clinical features; no specific laboratory abnormalities have been noted. The histopathologic perivasculitis is non-specific. Corticosteroid administration has been the most efficacious treatment. For serious complications, such as uveitis or meningoencephalitis, immunosuppressive agents can be used.

Adolescent↗
PubMedDate not supplied

Fine-needle aspiration biopsy: use in diagnosis and management of pediatric thyroid diseases.

Fine-needle aspiration (FNA) biopsy of the thyroid is a reliable, safe, cost-effective, and widely used test. Its introduction and application have had a significant impact in the management of nodular thyroid diseases in adults. However, its utility in pediatric practice is not recognized or emphasized. During the last 12 years we performed 10,971 FNAs; 57 (0.5%) were in patients younger than age 17 years. Among 47 of these biopsies, 66% were benign, 15% were malignant, 6% were suspicious for malignancy and 13% were nondiagnostic. Biopsy was most often (96%) performed for the evaluation of diffuse or nodular goiter. The most common benign cytologic diagnosis was colloid goiter in 17 of 31 patients (55%) and Hashimoto's thyroiditis in 9 of 31 patients (29%). There were no false-positive results and there was one false-negative cytologic result. Among patients who had malignancy proved histologically, nine patients (75%) had papillary thyroid cancer. In this study, FNA biopsy was crucial in deferring surgery in 28 of 47 patients (60%). It is clear that the application of FNA biopsy prevents unnecessary surgery and improves surgical selection of patients with thyroid malignancy. On the basis of our extensive experience, we recommend FNA biopsy as the first diagnostic test for pediatric patients with nodular thyroid lesions.

Journal Article↗