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Biomedical subjects

J R Gibbons

Publications and source records attributed to J R Gibbons.

At least 55 records · Page 3Linked to original sources
PubMed1988

Bronchopleural fistula. A novel type of window thoracostomy.

Bronchopleural fistula usually associated with chronic empyema after lung operations continues to occur in modern surgical practice. Successful treatment depends to a large extent on adequate dependent drainage of the empyema space. Tube thoracostomy, although useful initially, is unacceptable as long-term treatment. Window thoracostomy as currently performed is effective but unnecessarily extensive. We describe a simpler procedure, triangular window thoracostomy, for use as a permanent pleurocutaneous stoma or as an interim measure before definitive surgical treatment.

Bronchial Fistula↗
PubMed1987

High frequency jet ventilation for bilateral bullectomy.

This case report describes the use of high frequency jet ventilation for resection of bilateral lung bullae. Low airway pressures reduced the risk of pulmonary barotrauma. A continuous infusion of ketamine provided acceptable anaesthesia.

Adult↗
PubMed1985

Solitary squamous papilloma of the bronchus.

A case of solitary squamous papilloma of the bronchus is described and 11 other cases from the reports published worldwide are reviewed. These tumours present in middle aged men with symptoms similar to those of bronchial carcinoma. Treatment by bronchoscopic removal or lobectomy is usually curative. Symptoms are similar to those of bronchial carcinoma, but a correct preoperative diagnosis permits more conservative surgery to be carried out. Difficulties in the histological classification of papillary tumours of the bronchus are discussed.

Aged↗
PubMed1985

Thymectomy for myasthenia gravis.

The results of 14 years' experience in the surgical treatment of myasthenia gravis are reported. Twenty-one patients (14 female, 7 male) underwent thymectomy for myasthenia gravis between 1971 and 1984. The mean age of the patients was 33 years (range 14 - 57 years). The median duration of symptoms prior to surgery was 18 months (range 5 months to 35 years). The mean follow-up was 5.3 years. There were no post-operative deaths: 76% obtained benefit from thymectomy. The patients' age, sex, duration of symptoms and histology of the thymus gland did not correlate with the result of treatment. This series suggests that, while thymectomy is often beneficial in the treatment of myasthenia gravis, there are no accurate predictors of the outcome following surgery.

Adolescent↗
PubMed1981

Pulmonary blastoma with hilar lymph node metastases: survival for 24 years.

Pulmonary blastoma is a very rare tumor, consisting of relatively well-differentiated tubular glands embedded in a malignant mesenchymal stroma. Only 12 examples have previously been recorded in children. Despite lymph node metastases in the present case, the patient has survived for 24 years without evidence of recurrence following treatment by lobectomy.

Adolescent↗
PubMed1980

Granular cell tumor of the esophagus.

Granular cell tumor is an uncommon lesion which is usually seen in the tongue, skin and breast. It has rarely been noted in the esophagus, this case being the 16th in the literature. Eleven of these patients had tumors removed at operation and four were found at postmortem examination. The tumor appears to be benign in character, although one case has been reported with metastases. Granular cell tumors of the esophagus should be surgically removed and may require wide excision because of fixation of the mucosa. The pathological characteristics of this tumor are reviewed.

Adult↗
PubMed1976

Cyclic nucleotide phosphodiesterase activity of human normal and carcinomatous lung tissue.

The activity of the phosphodiesterase enzyme(s) responsible for the degradation of cylic adenosine monophosphate (CA.M.P.) and cyclic guanosine monophosphate (CG.M.P. (in human normal and carcinomatous lung tissue has been investigated. Enzyme activities were 3-5 times greater in normal than in carcinomatous lung. This is compatible with the known higher concentrations of these cyclic nucleotides in normal tissues. It is suggested that cancer chemotherapy designed to block the phosphodiesterase activity, and thus promote accretion of CA.M.P and CG.M.P., may provide a means of normalising cancerous tissue. Both phosphodiesterase activities in both types of tissue were inhibited by methylxanthines at 10(-3) mol/l, but some enzyme potentiation was observed at lower concentration.

2',3'-Cyclic-Nucleotide Phosphodiesterases↗