Biomedical subjects

J R Ebright

Publications and source records attributed to J R Ebright.

22 records · Page 2Linked to original sources

PubMed1980

Bacterial pneumonia in the elderly.

A retrospective study was made of patients having community-acquired pneumonia and treated at a large municipal hospital in 1973. Patients from nursing homes or other paramedical facilities were excluded. The incidence of Gram-negative bacillary pneumonia was significantly higher in elderly patients compared to two younger groups, and mortality from this type of pneumonia was higher than from pneumococcal or staphylococcal types or from pneumonia of unknown cause. Recommendations are made for the initial treatment of elderly patients with community-acquired pneumonia.

Adult↗

PubMed1979

Clindamycin-induced colitis.

The hamster model of enterocolitis after the administration of clindamycin was used to study various drugs used in treatment of the disease in humans. Current evidence strongly suggests toxigenic, clindamycin-resistant Clostridium difficile is a cause of the disease in hamster and man. This organism is susceptible to vancomycin and metronidazole, and the disease could be prevented in the hamster so long as the antibiotics were given orally. A fatal colitis almost invariably ensued once they were discontinued. Administration of cholestyramine significantly prolonged survival of hamsters, but did not pervent death or colitis. Corticosteroids or atropine-diphenoxylate (Lomotil) did not alter the disease. The hamster model may be useful in studying other kinds of treatment of this disease.

Animals↗

PubMedDate not supplied

Septic thrombosis of the cavernous sinuses.

Septic thrombosis of the cavernous sinuses (or cavernous sinus thrombophlebitis [CST]) is a dramatic and potentially lethal illness, which is still occasionally seen by clinicians. Before the availability of antimicrobial agents, mortality from CST was near 100%, but it markedly decreased to approximately 20% to 30% during the antibiotic era. Nevertheless, the threat of death and serious morbidity continues to necessitate early recognition, diagnosis, and treatment of CST to minimize risks to the patient. Accordingly, we reviewed the salient clinical features of this illness, with emphasis on newer aspects of diagnosis and treatment.

Anti-Bacterial Agents↗

PubMedDate not supplied

Evaluation of modified Stuart's medium in Culturettes for transport of Neisseria gonorrhoeae.

A prospective study compared rates of isolation of Neisseria Gonorrhoeae after immediate plating of clinical specimens onto Thayer-Martin medium with isolation rates after initial transport in modified Stuart's medium (MST) contained in Culturettes. Of 75 specimens positive for Neisseria gonorrhoeae after immediate plating onto Thayer-Martin medium, 65 (87%) were also positive after being held in MST medium for < or = 8 hr. Twenty (95%) of 21 clinical specimens remained positive after being held in MST medium for < or = 3 hr. However, the rates of isolation of N. gonorrhoeae were significantly reduced after transport for 24 and 48 hr; 60% and 27% of specimens, respectively, yielded N. gonorrhoeae-positive cultures after these intervals. Therefore, it is concluded the MST medium in Culturettes is an acceptable transport medium for specimens containing N. gonorrhoeae when transport time prior to inoculation of growth medium is < or = 3 hr.

Culture Media↗