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Biomedical subjects

J R Coffman

Publications and source records attributed to J R Coffman.

At least 37 records · Page 2Linked to original sources

Neutropenia and salmonellosis in hospitalized horses.

Colitis due to salmonellae was diagnosed in 9 horses following hospitalization for various reasons at the University of Missouri Veterinary Teaching Hospital, from May, 1971, to April, 1972. Diarrhea, fever, and either a neutrophil count of less than or equal to 3,600/cmm or a rapid decline in neutrophil numbers were specific for salmonellosis. The value of hematologic survelillance in hospitalized Equidae was demonstrated in another group of 9 horses with neutropenia, each of which was promptly treated and did not develop colitis. Bacteriologic culturing of fecal samples from 28 clinically normal horses yielded only 2 salmonella isolations, S manhattan in each case. The serotyped salmonellae isolated from the patients with colitis were all S typhimurium, with similar antibiotic resistance patterns.

Agranulocytosis↗

Angiographic appearance of the normal equine foot and alterations in chronic laminitis.

The angiographic appearance of the normal equine foot was compared with the appearance of equine feet affected with chronic laminitis. The normal foot was characterized by complete filling of the terminal arch, 8 to 10 main branches between 0.1 and 0.2 cm in diameter, a symmetrical netlike vascular pattern in the corium of the hoof, and numerous fine vessels in the corium of the coronary band. The feet affected with chronic laminitis were characterized by poor filling of the terminal arch, larger and less numerous primary branches, an irregular vascular pattern in the corium of the hoof, areas of the corium of the hoof that were apparently avascular, and irregular, tortuous vessels in the corium of the coronary band.

Angiography↗

Castration and other factors affecting the risk of equine laminitis.

The characteristics of a series of equine laminitis cases were compared with that of other Equidae examined at the University of Missouri Veterinary Hospital and Clinic during May, 1965 through December, 1971. The model age for ponies with laminitis was 7-9 years and for all other cases the model age was 4-6 years. Also the predominant age for mares was 4-6 years and for males was 7-9 years. After controlling for age and breed differences, there were significantly fewer castrated males among the affected males than expected (P small than 0.02), indicating that hormonal factors may play a role in laminitis. Ponies had a significantly greater risk of laminitis (P smaller than 0.001) and their relative risk was 4.3 times greater than all other Equidae combined. There were more laminitis cases diagnosed during May than during other months.

Age Factors↗

Equine laminitis of alimentary origin: an experimental model.

Acute alimentary form of laminitis was uniformly induced in 11 of 12 horses by administration of a starch and wood flour gruel and could be graded by previously established (Obel) and presently defined criteria. The experimentally induced laminitis was similar to naturally occurring laminitis, as determined on the basis of lameness severity and vital signs. Packed cell volume, leukocyte count, and total protein were significantly increased (P smaller than 0.05) at 24 and 40 hours after administration of gruel. Arterial systolic and diastolic pressures increased, central venous pressure decreased, heart rate increased, and rectal temperature increased consistently within the 56-hour experimental period. Of the 11 affected horses, 7 horses had Obel grade 3 lameness (horse moved most reluctantly and vigorously resisted attempts to lift a forefoot) at 40 hours after gruel was placed in the alimentary tract, 2 horses had Obel grade 3 lameness at 32 hours, and 2 horses had Obel grade 3 lameness at 48 hours.

Administration, Oral↗

Indirect blood pressure measurement in the dog.

The validity of the ultrasonic Doppler technic for indirectly measuring arterial blood pressure over a wide range was tested in anesthetized dogs. Correlation coefficents of 0.99 and 0.97 for systolic and diastolic pressure were verified on the basis of 316 comparisons of direct and indirect measurements. Utility of the method for detecting hypotensive, normotensive, and hypertensive arterial blood pressures was demonstrated. Potential applications of the method by life scientists and veterinarians includes routine monitoring of anesthesia, characterization of disease, and documentation of pharmacologic states.

Anesthesia↗

Monitoring and evaluating the physiological changes in the horse with acute abdominal disease.

Initial examination and therapy, and the avoidance of maltreatment are emphasized. Gastric decompression is of prime importance, after which no compound should be administered via stomach tube. Where large amounts of high starch grains are fed, primary acute gastric dilatation must be differentiated from that secondary to small bowel dilatation, by immediate gastric intubation and irrigation of the cardia with lidocaine. If cessation of pain and improvement of peristalsis and general attitude follow, the former state may be assumed. If pain persists and peristalsis does not improve markedly, one should assume small bowel displacement. Rectal examination is helpful in initial evaluation: impactions, inguinal herniation and ileocaecal intussusception may be diagnosed and small bowel displacement suspected. Palpation of one or more distended loops of bowel in the ventral middle third of the abdomen indicates small bowel displacement or ileus and flaccid distension. Distinction by rectal palpation alone is difficult. Palpation of the gas-distended apex of the caecum in the middle third of the abdomen is virtually pathognomonic for 180 degrees rotation of the large bowel. Abdominal paracentesis yielding true sanguineous effusion indicates a necrotizing segment of the bowel. If negative, such a segment is absent, or there is an infarcted segment, not yet damaged to the point of leaching whole blood, or the necrotizing segment is outside the peritoneal cavity, i.e., in the thorax, intussuscepted into the caecum, or herniated into the inguinal canal. Recurrent colics frequently may be due to verminous arteritis but the relationship to diet should be investigated. Recurrent colics after grain ingestion with occult blood in the faeces may be due to ulcers; such cases respond well to grain withdrawal. The advantages and disadvantages of phenothiazine-derived tranquillizers are discussed. They are contra-indicated if there is any evidence of circulating volume insufficiency but are benefical in many instances through improved peripheral perfusion of organs provided circulating volume is adequate, i.e., early in acute abdominal disease prior to development of circulatory insufficiency. They should not be administered if immediate surgery is contemplated because of hypotensive effects. The administration of oral antibiotics (Neomycin) early in the course of the disease is encouraged. This is contra-indicated if the horse is already toxic, when it should receive parenteral antibiotics, preferably chloromycetin. Tetracyclines may predispose to the later development of salmonella diarrhoea. Absolute analgesia should be provided; our preference is the magnesium sulphate-chloral hydrate solutions. Administration of mineral oil is desirable in initiation of peristalsis, depression of Gram-negative overgrowth and softening of impactioning obstructions but nothing should be administered per os if the stomach has required decompression.

Abdomen, Acute↗