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Biomedical subjects

J R Blickman

Publications and source records attributed to J R Blickman.

18 recordsLinked to original sources

[NMR imaging of the kidney].

NMR imaging was performed in 18 patients suffering from various renal disorders. 2 scanners were used, a 0.14T resistive prototype system and the superconducting Gyroscan S5. NMR imaging proved to be a very sensitive technique. Tumours as small as 5-10 mm were detected. Solid tumours and cysts could be distinguished. As a result of the excellent contrast resolution and tissue differentiation NMR imaging appears to be very accurate in the staging of renal cell carcinoma. Blood vessels within a tumour may be visible as little black dots. Because of their short T1 hemorrhagic cysts can be differentiated from simple cysts. Further prospective follow-up studies are required before a definite statement can be made as to the value of NMR imaging in diffuse parenchymal disease. Calcification were not detected. NMR imaging does not seem to be any more specific as to tissue characterisation than other imaging modalities.

Female

Computed tomography and sialography: 1. Normal anatomy.

Computed tomography (CT) has made it possible to identify soft tissue structures not visible by sialography. This paper reviews the normal anatomy in the region of the parotid and submandibular glands in the axial transverse and coronal planes as imaged by CT before and after sialography. A clear understanding of the normal structures is important before undertaking an evaluation of disease.

Humans

Computed tomography and sialography: 2. Pathology.

Computed tomography (CT) has added a significant amount of diagnostic information to the imaging of the salivary glands. Two groups of patients were evaluated at two institutions to determine the impact of CT on the diagnosis of various diseases and to evaluate the contribution of CT versus conventional sialography, respectively. Patients were studied by each modality alone and in combination. Emphasis has been placed on the group that had CT combined with sialography, since benign and malignant tumors were found to be better evaluated by the two techniques together.

Female

Instability in lumbar spondylolisthesis: a radiologic study of several concepts.

An attempt was made to define more precisely the notion of spine instability in lumbar spondylolisthesis. By means of lateral radiographs in flexion and extnsion, the axes of movement and the degree of mobility at the L3--L4, L4--L5, and L5--S1 levels were determined in 24 cases of true (spondylolytic) spondylolisthesis. Axes of movement at the spondylolisthetic levels showed a somewhat larger spread in and around the discs than at the normal levels, but instability in the form of parallel displacement of vertebral endplates was not observed. Hypermobility at the spondylolisthetic level proved to be a regular finding. The still current concept of "instability" as presented by Knutsson in 1944 was critically reviewed and denied as valid. Imprecision in the literature regarding instability may partly be attributed to insufficient discrimination between vertebral displacement as anatomic relationship and as abnormal type of movement. By designing a two-dimensional model other movements than flexion-extension could be studied; a special form of instability at the spondylolisthetic level was shown to appear during forward and backward movement of the lumbar spine above it. This detailed analysis facilitates understanding of the effect of different surgical procedures on vertebral movement and instability in lumbar spondylolisthesis.

Adolescent

Left atrial myxoma moving from right atrium to left ventricle. Non-invasive and invasive techniques and surgical findings.

A case of left atrial myxoma, prolapsing through a large atrial septal defect during systole and through the mitral valve orifice during diastole, is presented. To our knowledge this is the third such case and only the second one in which the diagnosis was made before operation. Echocardiography and phonocardiography were of great value in establishing the diagnosis of left atrial myoxoma; the features before and after operation are presented. In this patient the "swinging" of the tumor in the left atrium and in the left ventricle was echocardiographically visible. Correlations of tumor movement and heart sounds could be made. The diagnosis of a 36% left-to-right shunt on atrial level could not be made with the help of non-invasive techniques alone; cardiac catheterization revealed the shunt. The role of non-invasive techniques and of cardiac catheterization is discussed, together with a review of the relevant literature.

Cardiac Catheterization

Standardized induction of myocardial ischaemia in the dog.

Ischaemia in the entire left ventricular wall was induced in dogs by installment of ameroid constrictors on the left anterior descending (LAD) and left circumflex (LC) branches of the left coronary artery (series A). Ischaemia in the anterior left ventricular wall was induced by installment of an ameroid constrictor on LAD and ligation of all (series B) or part of (series C) the subepicardial intercoronary anastomoses between LC and LAD. The effect of the operation was studied by electrocardiography and coronary angiography and, post mortem by radiography of the coronary arteries and histopathology of myocardium and coronary arteries. The high early mortality rate in series A and B precludes the further use of these procedures. In series C the mortality rate was low and in half of the cases lasting myocardial ischaemia of the anterior wall of the left ventricle was produced. The development of a small myocardial infarction was inevitable, but it was healed by the time the sought after state of stable myocardial ischaemia was reached.

Animals

["Pointers"].

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Humans