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Biomedical subjects

J R Bennett

Publications and source records attributed to J R Bennett.

111 records · Page 7Linked to original sources
PubMedDate not supplied

Gastro-duodenal motility: 24 hour continuous recordings in normal subjects.

Twenty four-hour continuous recordings of gastric and duodenal motor activity were obtained in 12 normal subjects. A regular, cyclical variation in gastro-duodenal motility, consisting of periods of intesnse activity for 15--30 minutes alternating with periods of almost complete quiescence during the following 30--90 minutes, was noted in all subjects. All wave types previously described in short term studies were observed. Antral and duodenal activity were often linked, but there were many occasions when either occurred independently. Motor activity while the patient slept differed little from the waking pattern. There was no consistent motility pattern which could be associated with the subjects' hunger sensation. Eating was followed by a significant increase in duodenal motor activity which has not been previously described; the authors assume it to be due to endogenous gastrin release.

Adolescent↗
PubMedDate not supplied

Comparing the efficacy of cisapride and ranitidine in oesophagitis: a double-blind, parallel group study in general practice.

Patients with endoscopically confirmed oesophagitis (n = 49) were treated for 8 weeks with either cisapride (10 mg four times a day) or ranitidine (150 mg twice a day) in a double-blind study in general practice. Mean overall symptom scores fell from 10.8 to 4.5 in the cisapride group and from 9.9 to 4.4 in the ranitidine group over the course of the study. The proportion of patients reporting improvements in individual symptoms in the two treatment groups (cisapride and ranitidine respectively) were: heartburn, 66% and 55%; acid regurgitation, 53% and 47%; epigastric pain, 60% and 52%; satiety, 57% and 47%; bloating, 69% and 71%; belching, 65% and 72%; nausea, 62% and 85%; vomiting, 77% and 66%; poor appetite, 50% and 75%. Improvement in the endoscopic grade of oesophagitis was observed in 66% of patients receiving cisapride and 63% of those receiving ranitidine. It was concluded that cisapride is as effective as ranitidine in relieving the symptoms of oesophagitis and in healing oesophageal erosions.

Adolescent↗