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Biomedical subjects

J R Beljan

Publications and source records attributed to J R Beljan.

22 records · Page 2Linked to original sources
PubMedDate not supplied

A new in vivo method of quantitating the rate of magnitude of mineralization of an experimental osseous defect.

An in vivo, quantitative, non-destructive method of measuring bone mineral deposition in a repairing osseous defect has been developed. A circular osteotomy, used as a controlled fracture, was found to be extremely reproducible, and could be introduced with a minimum of trauma. The rate and magnitude of mineralization of the osteotomy was directly related to the attenuation of a highly collimated photon beam produced by Iodine-125. Changes in bone mineral content of 4% can be detected using this system.

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PubMedDate not supplied

The effect of fluoride supplementation on the strength of osteopenic bone.

The strength of osteopenic bone from calcium deprived rats, quail and roosters was significantly reduced after fluoride supplementation. Using a device which measures torque, femurs from rats fed low calcium diets with 100 parts per million fluoride added to the water supply fractured at lower torque values than those values observed for rats fed a low calcium diet without fluoride. Fluoride administration and calcium restriction in adult roosters and young Japanese quail also resulted in a reduction in bone strength. This detrimental effect on bone strength must be considered in any therapeutic attempt to use fluoride ion to stimulate bone formation in osteopenic bone disorders.

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PubMedDate not supplied

The effect of a constant direct current on the repair of an experimental osseous defect.

To investigate the effect of a constant direct electrical current on the mineral deposition in an experimental osseous defect, 8 microamperes of current were applied across a circular osteotomy placed in the lateral cortex of an avian metatarsus. Mineral deposition was measured to quantitate bone formation in vivo using iodine-125 absorptiometry. The electrical current had no effect either on the initiation or the rate of mineral deposition. However, the quantity of mineralized callus was significantly greater in the treated than untreated bones.

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