Biomedical subjects
Publications and source records attributed to J Quinn.
Long-term care is costing companies significantly in lost employee productivity. Case management services offer employers a way to ease the burden for employees with relatives who are chronically disabled and minimize disruption at work.
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HL7 is an organization with a short history and more activity now than ever before. Opportunities abound within HL& to assist in the development of the automation of healthcare and the deployment of information systems that create and support the electronic medical record. Finally, the continual advances in information systems technology enable HL7 to do more to meet the healthcare industry's needs.
Case management is one method for helping persons obtain needed health and social services while maximizing available community resources. How do needed case management services differ between rural and urban areas?
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Terminal deoxynucleotidyl transferase (TdT) was determined by immunofluorescence in 30 patients with leukemia. In acute lymphocytic leukemia the proportion of cells positive for TdT was 19 to 77 percent during relapse (12 cases) and less than one percent during remission (three cases). In seven cases of myeloproliferative disease and two cases of lymphoma, the TdT was less than one percent. In one case of generalized lymphoblastic lymphoma and five cases of chronic myelocytic leukemia with "lymphoblastic" crisis, the cells positive for TdT were moderately increased. The presence of TdT in blast cells appears to have diagnostic, therapeutic, and prognostic significance.
Tartrate resistant acid phosphatase (TRAP) has been demonstrated during relapse in the cells in the cerebral spinal fluid (CSF) in a patient with the clinical features of acute T cell lymphocytic leukemia which suggests this isozyme may be a marker for malignant transformation of some types of lymphocytes. The presence of TRAP may be helpful in establishing the diagnosis of a lymphocytic malignancy since normal lymphocytes appear to have tartrate sensitive acid phosphatase. The presence of TRAP can no longer be considered specific for hairy cell leukemia, since children with acute lymphocytic leukemia are being found with this isozyme in their malignant blasts. The presence of TRAP does not appear to be specific for T or B cell lines of malignant lymphocytes since it has been described in cells with either type of cell markers. The presence of TRAP seems most useful in differentiating lymphocytic malignancies from monocytic and histiocytic malignancies and from benign lymphocytoses when the cells of the peripheral blood and marrow may have similar morphologic features with routine staining.
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