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Biomedical subjects

J Puel

Publications and source records attributed to J Puel.

192 records · Page 11Linked to original sources
PubMed1975

[Serologic diagnosis of syphilis by the passive hemagglutination test].

The passive haemagglutination test in the diagnosis of syphilis was used with: 139 sera posing serological problems, 965 sera from subjects with syphilis at all stages of the disease and non-syphilitics. The percentages of agreement seen both in comparison of THPA with the TPI (94,5 p.cent) and the FTA abs test (97 p.cent) demonstrate its high degree of specificity and sensitivity. The reaction may be performed rapidly on a routine basis and requires little in the way of specialised material. These qualities should lead, in the near future, to the adoption of the T.P.H.A. as a routine examination in all laboratories, reserving the use of the F.T.A. abs test and the T.P.I. for difficult cases.

Fluorescent Antibody Technique↗
PubMedDate not supplied

Isolated aneurysm of the left sinus of Valsalva. Rupture into the left atrium, left ventricle and dynamic coronary constriction.

Aneurysms of the left sinus of Valsalva are exceptional. They may cause aortic regurgitation and may rupture into an extra or intra-cardiac location. We report an aneurysm of the left Sinus of Valsalva associated with 3 unusual complications: rupture into the left atrium, infected rupture into the left ventricle inducing aortic regurgitation and compression of the left circumflex coronary artery. These caused cardiac failure, coronary insufficiency and paroxysmal ventricular fibrillation. A review of the literature on the LASV has been undertaken.

Aged↗
PubMedDate not supplied

[Care and outcome of 55 children born to HIV seropositive mothers].

We report our experience with vertically transmitted HIV infection in infants. Fifty-five children were prospectively followed for a period of 3 years. The neonatal diagnosis of HIV infection is not always possible and doubts about contamination may create familial anxiety which requires support by a multidisciplinary structure. Long-term prognosis is difficult to predict and it depends on the severity of the immune deficiency, the early onset of neurologic disease and the frequency of opportunistic infections.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Percutaneous vascular stent: experimental studies and preliminary clinical results in peripheral arterial diseases.

A new pattern of metallic intravascular stent has been experimentally and clinically tested. When the stent is percutaneously placed through a six french introducer, it is held against the vessel wall by its natural elastic properties. In 28 animals, 47 stents of different sizes (from 3 to 5 mm of luminal diameter and from 1.5 to 5 cm of length) have been implanted in the femoro-popliteal (16), the coronary (20), the carotid (3) and the renal arteries (5) and in 3 femoral veins. Angiographic and histological results have shown the stent's low thrombogenicity when it is well fit to the vessel's caliber. Moreover, they have shown its incorporation to the vessel wall by intimalisation as early as the third week after its implantation. The collateral vessels which covered by the stent remain permeable. At the end of this experimentation, 10 implants have been achieved in 8 patients (4 recurrences of iliac stenosis and 6 femoral stenosis). The angiographic results show the perfect tolerance of the organism at 6 months. This good tolerance is revealed by a thin intraluminal border which does not change the artery's diameter. This confirms the experimental results. The permeability is good except for two patients who had an obliteration after one month (one iliac and one femoral obliteration).

Angioplasty, Balloon↗
PubMedDate not supplied

[Oral and injectable amrinone in cardiac insufficiency].

The authors report the results of a study of amrinone which was prescribed orally and by injection. 12 patients with stage III congestive heart failure were treated with oral amrinone. Prior to inclusion in the trial, all of the patients underwent a complete clinical, radiological and laboratory examination. They were examined by ergometric haemodynamic tests with measurement of the cardiac output and by echocardiography. After discharge from hospital, the patients were reviewed clinically every week and cyclo-ergometric and echocardiographic examinations were performed at 4, 8 and 12 weeks. At the end of the study, a further haemodynamic survey was performed in 8 patients. Two patients left the trial because of thrombocytopenia which appeared between the 10th and 25th day of treatment and 2 others left the trial (1 death, 1 treatment failure). In the 8 patients who completed the trial, the authors found: a functional improvement (improvement by one NYHA class within 3 months), a mean gain of 40 Watts at the last stress test, an 11% improvement in the ejection fraction and in the rate of circumferential shortening, a decrease in the filling pressure (16 mm Hg) and an improvement in the cardiac index (mean of 700 ml). A haemodynamic study was conducted in 4 patients who received amrinone by injection (1 mg/kg by slow intravenous injection, followed by an infusion of 10 ng/kg/min). The authors observed a mean drop in left ventricular end-diastolic pressure of 9 mm Hg an increase in the cardiac index of 1.02 l/min/m2, without any significant variation in the mean blood pressure or the heart rate.

Administration, Oral↗
PubMedDate not supplied

[Threatened extension of myocardial infarction in situ and coronary spasm].

The authors report a case of threatened spread occurring 4 days after posterior-inferior myocardial infarction and involving the same territory. The spontaneous occurrence during coronary angiography of an occlusive spasm of the right coronary artery with recurrence of angina and ST elevation in the area of initial necrosis suggests that this mechanism might be the contributory factor to the threat of in situ spread. Thus intermittent coronary occlusion from repeated spasm can bring about incomplete necrosis of the area of dependent myocardium and by extension threaten the viability of groups of still healthy cells. A syndrome of this kind initially requires coronary-dilating medical treatment, with nitrate derivatives and calcium inhibitors and then early coronary angiography with the use of pharmacodynamic tests to assess the suitability of surgery.

Adult↗
PubMedDate not supplied

[Study of the transplacental transfer of interferon alfa-2a on the model of isolated perfused cotyledon].

Interferon can be used for VIH+ pregnant women, to decrease materno-fetal contamination. Added to maternal circulation, its behaviour was studied by human placental cotyledon ex vivo perfusion. Human recombinant IFN 2a and reference substance 3H2O were injected in intervillous chamber and their behaviours in venous fetal and maternal circulations was followed. At steady state, in fetal circulation 3H2O concentration was 37% of injected rate whereas no IFN transfer rate was observed. In both venous circulations IFN amounts were lower than injected ones 56% versus of 82% for water (p < 0.05). IFN didn't cross placental filter and disappeared partially during placental contact.

Chorionic Villi↗