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Biomedical subjects

J Pris

Publications and source records attributed to J Pris.

At least 91 records · Page 5Linked to original sources
PubMed1976

Distribution of G6PD types in the population of southwest France: common variants and new variants.

Glucose-6-phosphate dehydrogenase was purified from blood samples originating from 33 subjects living in the 'Midi-Pyrenees' region (Southwest France). Biochemical and electrophoretic characteristics of several enzymatic variants were revealed. The distribution of the mutations in the subjects studied gave the following results: (1) Meditteranean Gd(-) and Gd(-)A identified variants; they constitute the main part of our observations. (2) Two original variants confirmed by the WHO International Reference Laboratory, that is: Gd(-) Toulouse and Gd(+) Luz-Saint-Sauveur; the latter mutation did not produce any haematological disorder. Absence of chronic haemolytic anaemia as well as a high rate of favism could be found in the families studied. As it is generally observed in Mediterranean regions, Southwest France population is characterized by a certain heterogeneity in biochemical and genetic mutations.

Erythrocytes↗
PubMed1975

[Cerebrospinal fluid cytology in acute leukemias. (Use of cytocentrifugation for blast cell identification)].

The authors studied cerebrospinal fluid (CSF) in 51 patients with malignant blood diseases. 136 assays were performed over a three month period. In children, two technics were used; in the first case, smears were done with cells obtained through centrifugation; in the second case, CSF was directly thrown on glass slides in a special cytocentrifuge. Only the latter was performed for adults. In each case, the results of the cytological analysis were compared with those of cyto-chemical assay and clinical status.

Adolescent↗
PubMed1975

[Association of Fanconi's disease and hepatic tumor in a patient undergoing long-term androgen treatment].

A Fanconi's disease was discovered in a 9 1/2 year old girl. She received androgens daily and died with a severe aplastic attack after 4 years of evolution. Hepatic involvement of treatment with androgens was regularly checked. Autopsy however, showed a multinodular adenoma of the liver without any malignant manifestation. Relationships between aplastic anemia, long-term treatment with androgens and tumour of the liver are discussed. The difficulty of in vivo diagnosis is emphasized.

Adenoma↗