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Biomedical subjects

J Powell

Publications and source records attributed to J Powell.

At least 163 records · Page 9Linked to original sources
PubMed1994

Cancer of the colon and rectum in the West Midlands, 1957-1981.

Between 1957 and 1981, 49,904 patients with large bowel cancer were registered at the Birmingham Cancer Registry. The annual incidence was 24.5 per 100,000 population for colonic cancer and 18.4 per 100,000 for that of the rectum. The annual number of patients increased by 41.9 per cent. The age-adjusted 5-year survival rate was 26.4 per cent for colonic carcinoma and 28.2 per cent for rectal cancer. Between 1977 and 1981 these rates increased significantly to 30.3 and 30.0 per cent respectively (P < 0.01). Stage for stage, colonic cancer was associated with longer survival than that of the rectum. Curative and palliative resection rates increased, especially for anterior resection. The operative mortality rate remained constant at 8 per cent. Despite increases in palliative resection rates 50 per cent of these patients required a stoma. Treatment was not undertaken in 37.4 per cent of patients. The end results of treatment are little better than those reported previously from this registry.

Adult↗
PubMed1994

The efficacy of a sonographic morphology index in identifying ovarian cancer: a multi-institutional investigation.

Transvaginal sonography (TVS) has been shown to be the most effective means to screen for ovarian cancer. TVS is associated with a high sensitivity and specificity. However, the positive predictive value associated with TVS in the diagnosis of malignancy is low. A morphologic scoring index for use with TVS has been used at the University of Kentucky since 1991. The current study was performed to more fully evaluate the efficacy and interobserver variation in ultrasonographic morphology index scores attributed to ovarian tumors. Ultrasound records of 213 patients from five participating centers were reviewed by three independent observers. Morphology index scores were assigned to each tumor in a blinded fashion. The morphology index scores were then compared with the final histopathologic findings. One hundred sixty-nine patients had benign tumors and 44 patients had ovarian malignancies. The mean morphology index scores were significantly higher in malignant ovarian tumors (MI 7.3 +/- 1.9) than in benign ovarian tumors (MI 3.3 +/- 1.8). Statistical evaluation of the morphology index scores revealed a sensitivity of 89% and a positive predictive value of 46%. Interobserver variation was lowest in assessing ovarian volume and higher in the evaluation of wall structure and septal structure. A multilogistic regression model was used to evaluate the predictive power of each component of the morphology index. The use of a morphology index is an effective and cost-efficient method of increasing the positive predictive value of TVS screening for ovarian cancer. Use of this index in large numbers of patients will generate data which should help refine appropriate structural scoring categories and reduce interobserver variation.

Adolescent↗
PubMed1994

A comparative analysis of distraction rods versus Luque rods in thoracic spine fractures.

The findings of this study emphasize the importance of distraction in obtaining and maintaining reduction in upper thoracic fractures that are unstable and collapsing into kyphosis. It also shows that a Luque rectangle construct cannot fulfill this function adequately in this type of fracture. Thirty-four consecutive cases of surgically treated upper thoracic spine fractures were reviewed. Two patients died, and 4 were lost to follow-up, so after a minimum 6-month clinical and radiographic follow-up there were 11 patients in the Luque group and 17 in the distraction rod group. Preoperatively, there was no significant difference in age, sex, level of injury or severity of kyphosis between the two groups. The Luque stabilization took an average of 1 h longer. There was no difference in local, general or neurological complications between the groups. Pain at the final follow-up was the same according to analgesic use. The kyphosis in the Luque group increased progressively from preoperative to postoperative values continued and to increase. In the distraction rod group the postoperative kyphosis was improved compared with the preoperative values. At final follow-up the kyphosis had returned nearly to the preoperative values. The difference in the adequacy of the reduction as measured by percentage of anterior collapse between the two groups is highly statistically significant: distraction rod better postoperatively, P = 0.0114 (Student's t-test); distraction rod better at final follow-up, P = 0.0054 (Student's t-test).

Adult↗
PubMed1994

Biomechanical comparison of methods of fixation of isolated osteotomies of the posterior acetabular column.

Ten fresh frozen specimens of a hemipelvis, including the hip joint, capsule and proximal femur, from elderly cadavers were used to evaluate three methods of internal fixation of isolated posterior column osteotomies. Intact and reconstructed specimens were tested at 30 degrees and 60 degrees of hip flexion in a specially designed joint simulator. The three methods of fixation used were a single 3.5 mm reconstruction plate, two such plates, and a 4.5 mm lag screw with a single plate. Motion at the fracture site in three orthogonal directions, and the overall stiffness of the construct, were recorded simultaneously. No significant differences were noted in stiffness for the three procedures and all retained 80% of the intact stiffness. At 60 degrees of flexion, smaller interfragmentary compliances were allowed by fixation with a lag screw and a neutralisation plate (p < 0.05). At 30 degrees, the position of the load plane relative to the fracture plane allowed less interfragmentary motion, so that no significant differences were found between the 3 methods.

Acetabulum↗
PubMed1994

The effect of thread length and location on extraction strengths of iliosacral lag screws.

Although iliosacral lag screws are an established technique for fixation of sacroiliac joint dislocation and sacral fractures, there is a paucity of data on the relative strength of fixation of screws in the sacral ala and body. The purpose of this study was to quantify and compare the extraction strength of cancellous screws in the sacral ala and body. Twelve fresh frozen cadaveric human pelves (mean age 76) were used to test the extraction strength of three groups of 7.0 mm cannulated cancellous screws: long-threaded in the sacral body, short-threaded in the body and short-threaded in the ala. The mean extraction strengths were 925, 374 and 71 newtons (or 92, 37, and 7 kg) respectively. The differences between the three groups were highly significant (all P < 0.0025). These data strongly recommend that the goal in iliosacral lag screw fixation should be to insert a long-threaded screw into the sacral body, if safely feasible. Fixation in the ala is inferior and should be avoided in the elderly.

Aged↗
PubMed1994

The influence of the operating surgeon's specialisation on patient survival in ovarian carcinoma.

A retrospective analysis of ovarian cancer patients registered with the West Midlands Cancer Registry from 1 January 1985 to 31 December 1987 was undertaken to examine the variables associated with survival patterns, with particular reference to the specialty of the surgeon. A total of 1,654 patients were registered, of whom 1,184 had histologically confirmed ovarian cancer, with the operator identified. This consisted of 870 patients operated on by gynaecologists and 314 operated on by general surgeons. A significantly older population and a greater number of patients with stage III/IV disease were operated on by general surgeons. The median survival of patients under the general surgeons' care was 9.87 months, significantly lower (P < 0.0001) than the survival of the gynaecologists' patients (median survival = 29.1 months). Univariate and multivariate analysis correlated poor prognosis with advanced stage disease, older age, the presence of bulky residual tumour and a general surgeon as the operator. Stepwise Cox's proportional hazard analysis confirmed the general surgeon as an independent adverse prognostic factor with a relative hazard ratio of 1.34 (95% confidence interval = 1.05-1.71). Accepting the limitations of retrospective reviews, these findings suggest that every attempt be made to ensure that a gynaecologist is involved in the treatment of patients with ovarian pathology.

Adolescent↗
PubMed1994

Clozapine therapy and clinical outcomes in Kentucky psychiatric hospitals.

We reviewed the protocol for determining patient eligibility to receive clozapine in Kentucky state psychiatric facilities. Results of a retrospective review of the clinical outcomes of the initial 42 patients who received clozapine under this protocol are reported. Patients receiving clozapine were severely ill patients with a mean duration of illness and mean length of current hospitalization of 11 years and 2 years, respectively. Symptomatic response was dramatic with a reduction in total Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) ratings of 48.4% and 36.3%, respectively. The time patients spent in restraints decreased significantly following clozapine initiation. Clozapine was well tolerated, with sedation being the most common adverse effect reported. One patient experienced a seizure and another developed leukopenia. Following 12 weeks of clozapine treatment, the patient discharge rate was 42.9%.

Adult↗
PubMed1994

Involving consumers in assessing service quality: benefits of using a qualitative approach.

Although important to users, practice standards rarely incorporate users' views of care provided. These views are a valuable source of information, even though there are limits to their value. To improve the standards of care in a 20 bed hospital elderly care unit caring for acute medical conditions a qualitative approach was used. Patients' and carers' perceptions of care and problems with the process of care in the unit were elicited with a specially designed semistructured interview schedule in 83 separate tape recorded interviews with a research nurse in patients' homes. In all, 50 patients and 35 carers were interviewed between 6 June 1991 and 28 May 1992. Of the 50 patients, 33 were female; seven patients were aged less than 80 years, 16, 80-85; 21, 86-90; and six over 90. A total of 16 patients lived with spouses or other carers, two with non-carers, and 32 lived alone, 18 of whom received informal care. Content analysis of the interviews disclosed patients' and carers' general satisfaction with individualised professional care and planning of follow up services on discharge but dissatisfaction in the lack of information about and involvement in treatment and care and about specific staff notes. These findings have prompted remedial changes in clinical practice in the unit; they have also formed the structure of a criterion based survey of practice. The authors conclude that the qualitative approach suited elderly users and also provided the basis for the findings to be incorporated into a continuous audit cycle through a process of feedback and standard setting.

Aged↗
PubMed1993

A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11.

We report the results of a collaborative linkage study using 12 polymorphic markers (9 loci) from the long arm of chromosome 11, and 24 families multiply affected with schizophrenia and other closely related disorders. This region is of interest because several families have been reported in which balanced translocations involving 11q apparently co-segregate with psychotic illness. In addition, the dopamine D2 receptor, porphobilinogen deaminase, and tyrosinase genes map within the region studied and may be aetiologically involved in schizophrenia. We have primarily analysed genotypic data by the LOD score method using a range of single gene models. In order to minimize error due to mis-specification of genetic parameters we have analysed data from markers at candidate gene loci by the non-parametric extended sib-pair method in addition to the LOD score method. Our results suggest that most of the region can be excluded from containing a gene of major effect in the aetiology of this disease.

Alleles↗
PubMed1993

The gene for Darier's disease maps to chromosome 12q23-q24.1.

Darier's disease is a rare autosomal dominant skin disorder in which there is abnormal adhesion between keratinocytes. It appears to be associated with an increased prevalence of neuropsychiatric disorders including mental retardation and epilepsy. In addition we have previously reported a family in which major affective disorder cosegregates with Darier's disease. In the present study we have localized the gene for Darier's disease to chromosome 12q23-q24.1 by linkage analysis in five British pedigrees. We obtained a maximum two point lod score of 4.29 with marker D12S84 at zero recombination fraction. All five families showed evidence of linkage between the disease gene and markers in this region. Subsequent identification of the Darier's disease gene will provide insights into normal mechanisms of cell adhesion and may be of importance in the genetic investigation of neuropsychiatric disorders as well as elucidating the pathogenesis of Darier's disease itself.

Chromosome Mapping↗
PubMed1993

Cerclage wiring in internal fixation of acetabular fractures.

In the last 100 fractures of the acetabulum surgically treated in our institution, cerclage wires have been used as a reduction tool in 14 patients. In each case the fracture pattern affected both columns, and nine of them were approached through a single ilioinguinal exposure. To evaluate our initial experience with the method, these patients were reviewed using medical records, operative notes, and radiological assessment to determine its indications and effectiveness. In each patient, using a limited further dissection, at least one cerclage wire was passed through the greater sciatic notch, embracing the proximal extent of a posterior column fragment. It was then tightened above the anterior-inferior iliac spine, achieving reduction. In 11 cases reduction was obtained to within 1 mm, and joint congruence with < 3 mm of residual displacement was obtained in 13 hips. This reduction was maintained until union, except in one case, where it was lost postsurgery. Cerclage wires may be used to successfully effect an indirect reduction of the posterior column from an anterior approach in fractures affecting both columns, where the posterior column fracture line is proximal. The technique may contribute to fracture stabilization, but supplementary fixation was added in 12 of our patients.

Acetabulum↗
PubMed1993

Does post-withdrawal cue exposure improve outcome in opiate addiction? A controlled trial.

A controlled trial studied whether cue exposure prevented relapse in opiate addiction. Subjects were randomly allocated to one of two inpatient treatment settings: a drug dependence unit with a special 10 week program and 4 weeks in a behavioural/general treatment unit without such a program. In each setting, following drug-withdrawal, subjects had either cue exposure for at least six sessions over 3 weeks, or a control condition. Subjects were followed up twice, at about 6 weeks and 6 months post-treatment. 186 subjects were randomly allocated; 69 were assessed post-detoxification, and of these 43 completed cue exposure or control treatments. Cue exposure and control subjects did not differ in cue reactivity. This was evaluated post-treatment for cue exposure subjects and at a comparable time point for controls. All groups showed a significant decrement in cue-elicited craving, withdrawal responses and negative mood. Cue exposure and control subjects did not differ at either of the two follow up interviews.

Adult↗