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Biomedical subjects

J Poulsen

Publications and source records attributed to J Poulsen.

At least 55 records · Page 3Linked to original sources
PubMed1983

Treatment of infected surgical wounds with Varidase.

In 18 patients with subcutaneous wound infection after laparotomy the wounds were randomly treated with normal saline solution or with Varidase solution after complete opening, according to a double-blind system. Treatment was discontinued when the wound was clean enough for secondary suture or the patient could be discharged from hospital. Three patients, in whom the treatment was not completed because of intercurrent complications, were excluded from the evaluation. When the double-blind code was broken, 11 patients were found to have received saline treatment and 7 Varidase. The duration of the wound-dressing periods averaged 13.45 +/- 6.77 days in the former group and 5.00 +/- 2.16 in the latter. The difference is statistically significant.

Adult↗
PubMed1981

5-S-Cysteinyldopa in ganglion stellatum.

5-S-Cysteinyldopa, an amino acid formed by nucleophilic addition of cysteine to dopaquinone, has been detected in the ganglion stellatum of the cow in amounts varying between 21 and 35 ng/g ganglionic tissue. Dopa was present in slightly higher quantities. Cysteinyldopa has previously been regarded as a substance unique for the melanocytes, where it forms melanin after oxidation and polymerization. At present only hypothetical explanations of our finding can be offered. The content of 5-S-cysteinyldopa in ganglion stellatum may be the result of dopa oxidation in ganglionic cells. An uptake mechanism for circulating cysteinyldopa may exist. Localization of cysteinyldopa to aberrant melanocytes or to aged SIF-cells in the ganglia should also be borne in mind.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1981

Effect of symptomatic therapy on motor difficulties in quantitative measurements of voluntary power.

Thirty-one multiple sclerosis patients in a stable phase were given intensive symptomatic therapy. Isometric and isokinetic measurements of voluntary power were used to assess the effect of the treatment. Twenty-one of the patients were improved, six unchanged and four aggravated. The relative improvement was on the average 35%, best in the weakest patients. Isokinetic measurements revealed a particularly good progress for the fastest movements, probably reflecting reduction of spasticity. The optimum effect of treatment was found on an average after three weeks. Such tests seem to be useful in following and analysing the training and possibly in establishing treatment models.

Adult↗
PubMed1981

Impaired pancreatic innervation after selective gastric vagotomy. Reduction of the pancreatic polypeptide response to food and insulin hypoglycemia.

The secretion of pancreatic polypeptide (PP) was studied in 38 duodenal ulcer patients before, 4 months after, and, in 25 patients, again 18 months after either selective gastric vagotomy or parietal cell vagotomy. Selective gastric vagotomy on average reduced the PP response to food measured 4 months after operation to 20% of the preoperative value. The prolonged PP response (30-120 min) increased to 50% from the 4th to the 18th postoperative month (p less than 0.005). Parietal cell vagotomy did not significantly change the PP response to food, although in a few patients (3/15) the response was reduced to below one third of the preoperative value. The PP response to insulin hypoglycemia was measured after operation in 16 patients; those who had a reduced PP response to food demonstrated a response to hypoglycemia which was reduced to the same extent. It is concluded that PP secretion is generally unaffected by parietal cell vagotomy but is impaired after selective gastric vagotomy and that the prolonged PP response to food is partially regenerated after vagotomy. It is suggested that selective gastric vagotomy interferes with the vagal innervation of the PP-rich head of the pancreas.

Adult↗
PubMed1981

DOPA in sympathetic nerve tissue--a possible source of serum DOPA in albino animals.

Dopa, catecholamines, and dopac were determined in superior cervical ganglia of albino rats. The average amount of dopa in ganglia of control animals was 1.1--1.6 micrograms/g. The concentrations of catecholamines and dopac were similar to values reported by others. The tyrosine hydroxylase inhibitor alpha-methylparatyrosine methyl ester caused marked decrease in the dopa concentration in the ganglia. The effect of reserpine was less pronounced. The aromatic amino acid decarboxylase inhibitor NSD 1015 markedly increased the dopa concentration.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1981

Parathyroid carcinoma; a cause of recurrent primary hyperparathyroidism a few years after removal of a parathyroid adenoma.

This is a case report of recurrent hyperparathyroidism due to parathyroid carcinoma. Primarily a neck exploration revealed an adenoma of the inferior right parathyroid body but at cervical re-exploration 4 years later due to recurrence a parathyroid carcinoma at the opposite side was found. The importance of recognizing the malignancy at operation is emphasized and the author's opinion for the necessity of localizing studies in cases of reoperations at the neck for over-functioning parathyroid glands is expressed.

Adenoma↗
PubMed1980

Food-stimulated serum calcitonin concentrations in patients with ulcer negative dyspepsia, duodenal ulcer and in controls.

In 12 normals serum calcitonin (CT) concentration decreased significantly when eating wtih a return to basal value and a significant postprandial fall. No difference was observed in the food-stimulated CT secretion between duodenal ulcer patients and normals. In 25 patients with ulcer negative dyspepsia a significant increase in serum CT concentration occurred during food intake followed by a return to basal level and a secondary significant rise. The pattern in patients with ulcer negative dyspepsia differed significantly from patients with duodenal ulcer and normals.

Adult↗
PubMed1980

Ranking of glucocorticoid creams and ointments.

20 corticosteroids ointments and 19 corticosteroid creams available on the Swedish market in January 1977 were tested for their blanching effect. Three ointments and three creams showing pronounced blanching were tested only without occlusion. Hydrocortisone preparations were tested only with occlusion. Other preparations were tested with and without occlusion. All ointments and creams were tested at four randomized sites on the flexor aspect of the forearm in each of 11 or 12 subjects. When used occlusion was applied for 6 hours. Repeated readings were made, using scores 0, 1, 2, and 3. The reading at the time when most preparations showed blanching were analysed statistically. The scores for blanching showed a Poisson distribution when the mean score was less than or equal to 1. Classification of preparations according to blanching was facilitated by the fact that statistical methods for Poisson distribution could be used. A ranking of corticosteroids based on vasoconstriction was obtained, and four different groups for ointments and four for creams emerged. The arbitrary nature of any ranking and grouping of steroids is evident from the data presented.

Administration, Topical↗
PubMed1975

Mucous glands in the developing human nose.

In 56 fetuses the development and spread of the nasal glands were studied by three different whole-mount methods. Development starts anteriorly in the nose and proceeds with a given regularity backward. The anterior nasal, serous glands are found only most anteriorly in the nose. They are laid down in the 11th week by the formation of long ducts that grow backward. Small seromucous glands start forming in the 13th week. They gradually spread backward in the middle and inferior meatus and hence to the medial and lateral surfaces of the inferior and middle conchae. They are present in all parts of the respiratory region except in a small area above and behind the nasal vestibule and behind the conchae, Bowman glands start developing in the 16th week, in the roof of the nose, and gradually spread down through the entire olfactory region. They are very small, tubular, and serous. Bythe 23rd week gland formation has been completed.

Exocrine Glands↗
PubMed1975

Density of goblet cells in the developing nose.

On ten foetuses, ranging in age from the 13th to the 30th menstrual week, the entire nasal mucosa was removed, stained by the PAS-alcian blue whole-mount method, and the density of goblet cells in the various parts of the nose was determined quantitatively. For each locality there was a characteristic density curve, consisting of an increase, a peak, and a decrease. The following factors, influencing changes in density, are discussed: (1) Spread of goblet cells causing the density to increase first in the anterior part of the nose, where goblet cells appear first. (2) Growth of the mucosa whose area increases constantly and regularly. (3) Intensity of goblet-cell newformation which is high during the first weeks, but is then followed by a period of decrease. (4) Lifetime of the goblet cells which is presumably longer in the respiratory tract than in the intestinal epithelium.

Cell Count↗