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Biomedical subjects

J Pouchot

Publications and source records attributed to J Pouchot.

At least 91 records · Page 5Linked to original sources
PubMed1995

[Osteoarticular tuberculosis. Diagnostic contribution of local sampling].

Bone and joint tuberculosis have recently gained a renewal of interest, especially with the spread of HIV infection which may increase its frequency. Bone and joint locations of tuberculosis are pauci-bacillary often requiring local sampling in order to confirm the diagnosis and to initiate early therapy. From 1983 to 1992 we have studied 19 patients with bone and joint tuberculosis. Seventeen local sampling were performed: 12 biopsies and five abscess punctures. Pathological examination of samples disclosed diagnosis of tuberculosis in eight cases out of 12. Among the remaining four patients, direct smear was positive once, and cultures grew Mycobacterium tuberculosis in two, yielding the diagnosis in 11 out of the 12 patients. Bacteriological and pathological examinations were non contributive in only one patient. Microbiological examination of pus disclosed two positive direct smear and three positive cultures. Treatment lasted 9 to 18 months. The outcome was favourable in all patients.

Abscess↗
PubMed1995

Cauda equina compression by epidural lipomatosis in obesity. Effectiveness of weight reduction.

Epidural lipomatosis (EL) is characterized by abnormal accumulation of unencapsulated fat in the epidural space, and usually occurs as a complication of longterm steroid therapy. This condition, which may result in devastating neurologic complications, has also been reported without exogenous steroid intake. We describe a case of nonsteroid induced symptomatic EL associated with obesity, and emphasize the possibility of effective medical management of this entity with weight reduction instead of decompressive laminectomy whenever neurologic symptoms are mild and stable.

Cauda Equina↗
PubMed1995

[Fever with normal sedimentation rate. 30 cases].

Thirty patients (19 females, 11 males), with a mean age of 42 +/- 21 years, who presented a fever associated with a normal sedimentation rate prospectively studied. Mean fever duration at admission was 11 days (range: 1-90). Diagnosis included bacterial (12 cases) or viral (9 cases) infections, malaria (2 cases), systemic disease (2 cases), abnormal temperature control (2 cases) and lymphoma (1 cases). One patient simulated fever, and in the remaining case fever was of unknown origin. Identified factors implied in the mechanisms of normal sedimentation rate were: intravascular disseminated coagulation (5 cases), haemolysis (5 cases), late increase of inflammatory proteins (8 cases), red blood cell abnormalities (7 cases), cryoglobulinaemia (1 cases). This study suggests that the striking association of fever and normal sedimentation rate should lead clinicians to look for plasma and red blood cell abnormalities after ruling out a non inflammatory febrile disorder.

Acute-Phase Proteins↗
PubMed1994

[Measurement of quality of life in rheumatic practice].

Hard, objective data to evaluate outcome in patients with rheumatology diseases is not only difficult to obtain, but often poorly correlated with the degree of the functional incapacity caused by these non-fatal but disabilitating diseases. Soft, subjective data does not meet the traditional criteria for scientific research. However, due to important advances in the field of psychometry and its medical applications, we now have adequate instruments to evaluate quality of life, the major outcome parameter in patients with chronic rheumatic diseases. The Arthritis Impact Measurement Scales is the most widely used and is particularly adapted to patients with rheumatoid arthritis. Other scales include the Health Assessment Questionnaire, the Nottingham Health Profile, and the Sickness Impact Profile. Most of the studies conducted in the field of rheumatology concern patients with rheumatoid arthritis or osteoarthritis of the lower limbs. Quality of life measures can however be applied to most all the different clinical situations including low back pain, ankylosing spondylitis and systemic diseases. Quality of life measures will play an important role in treatment evaluation procedures. They correspond to real progress in responding to the legitimate demand of patient with chronic diseases for effective validated health care.

Health Status Indicators↗
PubMed1993

[Quality of life and osteoarthritis. Values and applications].

Health status is commonly appreciated with classical clinical, laboratory, or radiographic features. Quality of life measurement has been recently included in the health status evaluation in order to appreciate how individuals perceive the impact of their disease as a whole. Although osteoarthritis is the most common rheumatologic disorder, studies including quality of life as an outcome in this disease are scant. Most likely explanations are the heterogeneity of osteoarthritis, and the fact that the majority of clinicians considers that pain, functional status, and quality of life are highly correlated. Quality of life measurement could be useful in the study of future anti-rheumatic drugs, and osteoarthritis disease course. The selection of the most appropriate quality of life instrument is difficult, and both generic and disease specific health status measures are worthy. Most of the quality of life instruments have been developed in English, and their use in a foreign language should require a translation, an adaptation, and a careful study of validity before they could be used widely.

Clinical Trials as Topic↗