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Biomedical subjects

J Portnoy

Publications and source records attributed to J Portnoy.

At least 73 records · Page 4Linked to original sources
PubMed1979

Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy.

The administration of cephradine prophylactically to patients who were undergoing vaginal hysterectomies resulted in a marked and significant reduction in the incidence of postoperative infections when compared to a placebo group. Cephradine was the cephalosporin studied because of its unique pharmacodynamic properties, which result in high uterine tissue levels. The protective effect was similar whether 1 g was given preoperatively followed by 500 mg IV q. 6 hours for 4 doses, or a single dose of 2 g IV given approximately 1 hour before surgery. Uterine tissue and serum levels of antibiotic were high and correlated with the degree of protection noted.

Adult↗
PubMed1976

Safety of the bolus administration of gentamicin.

A study was done to assess the safety of gentamicin administration by a bolus method. A total of 63 patients were randomly treated with intravenous gentamicin by bolus administration (3 to 5 min) and by slow infusion (2 h). Serum gentamicin levels were measured. Renal and audiovestibular function were monitored. Pure-tone audiometry was performed at the beginning, on day 3, and at the end of therapy. The study revealed that the bolus administration was safe and nontoxic.

Adult↗
PubMed1975

Disseminated gonorrhea: diagnosis through contact tracing.

Over a 1-year period four patients were seen at the Jewish General Hospital with presumed disseminated gonococcemia. The patients' histories, clinical findings and responses to therapy strongly supported this diagnosis; however, cultures from various sites were negative for Neisseria gonorrhoeae in all four patients. Sexual contacts of these patients were traced and appropriate cultures were found to be positive, demonstrating the importance of tracing sexual contacts to help confirm the diagnosis in such patients.

Adult↗
PubMed1975

Self-inoculation with milk as a cause of recurrent cellulitis.

A 21-year-old patient had six admissions to hospital for recurrent cellulitis over a 6-month period. She underwent extensive investigations, which failed to reveal any underlying predisposing factors. On the final admission she admitted to injecting herself subcutaneously with milk to induce the lesion. Self-inoculation with foreign material must be considered in patients presenting with recurrent cellulitis.

Adult↗
PubMed1974

Meningococcal meningitis: an atypical case.

A case of meningococcal meningitis is described in a patient who had not received antibiotics before admission. Three lumbar punctures were performed over a seven-day period, but only the cerebrospinal fluid from the third yielded a positive culture. The importance of repeated lumbar punctures in patients with undiagnosed meningitis is emphasized.

Adult↗
PubMed1974

Brill-Zinsser disease: report of a case in Canada.

This report documents the occurrence of Brill-Zinsser disease in a 48-year-old woman who experienced typhus fever in a German concentration camp. This is the first report of a case of recrudescent typhus in a European immigrating to Canada following World War II. The last reported case of Brill-Zinsser disease in Canada occurred in 1953.

Canada↗
PubMed1974

Asymptomatic gonorrhea in the male.

In a prospective study, 133 male contacts of 102 women with gonorrhea were examined. A diagnosis of gonorrhea was made in 63 patients, indicating an infection rate of 47% after exposure. Forty-three percent of the patients with gonorrhea were asymptomatic. The duration of the asymptomatic period ranged from 3 to 154 days. The epidemiologic importance of this hidden infectious reservoir is stressed.

Canada↗
PubMed1974

Pharmacology of cephalothin in the biliary tract of humans.

Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic.

Adolescent↗
PubMed1973

Pharmacology of gentamicin in the biliary tract of humans.

Serum and biliary tract levels of gentamicin were determined in a large series of patients. In only 17.7% of subjects were therapeutic serum levels achieved, even though recommended doses of gentamicin were administered. Therapeutic bile gentamicin levels were reached in only some of the patients with therapeutic serum levels.

Adolescent↗
PubMedDate not supplied

Replacement of special enzyme immunoassay transport medium by a standard viral transport medium in the Herpcheck herpes simplex virus antigen detection test.

A new direct herpes simplex virus antigen enzyme immunoassay (EIA) uses a special EIA transport medium (ETM) for transport of herpes simplex virus (HSV) specimens. As ETM lyses the virus precluding culture and typing, we evaluated the relative performance of this EIA when performed on specimens transported in either ETM or a standard viral transport medium (VTM). These EIA results were also compared to cell culture performed on specimens transported in VTM (VTM-CC) and direct rapid inoculation into cell culture (CC). Based on all confirmed positives, by any test, the sensitivities for CC was 97% (66/68), for VTM-CC 91% (62/68), for ETM-EIA 97% (66/68), and for VTM-EIA 93% (63/68). It appears that VTM may be a slightly less desirable substitute than ETM in the performance of EIA. However, VTM-EIA is certainly as sensitive as cell culture performed on VTM.

Adolescent↗
PubMedDate not supplied

Reliable identification of herpes simplex viruses by DNA restriction endonuclease analysis with EcoRI.

A simple procedure that permits the rapid identification of clinical isolates of herpes simplex virus (HSV, type 1 or type 2) on the basis of stable and type-specific differences in the EcoRI restriction endonuclease patterns of the HSV-1 and HSV-2 genomes was tested for reliability. Complete concordance was first obtained for 298 HSV isolates typed by standard laboratory procedures and by analysis of the DNA profiles. Two other HSV isolates showing intermediate biologic, immunologic, and/or biochemical properties were unambiguously identified by restriction endonuclease analysis of their genomes. Identical diagnostic results were also obtained by independent laboratories for another series of 150 HSV isolates after analysis of the EcoRI digestion products. As compared with other restriction enzymes, little intratypic variation in the DNA fragments selected for immediate identification of the isolates was found with EcoRI. The procedure used here, which does not require the purification and/or the radiolabeling of viral DNA, thus appears as most appropriate for the unambiguous typing of large numbers of HSV clinical isolates.

DNA Restriction Enzymes↗