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Biomedical subjects

J Pooley

Publications and source records attributed to J Pooley.

23 records · Page 2Linked to original sources

Intraosseous pressure changes during simulated dives: fact or transducer artifact?

Anesthetized rabbits were placed in a compression chamber and the intraosseous pressure (IOP) in one femur was recorded during simulated dives to a depth of 20 m. No change in IOP was observed during any phase of these simulated dives. However the pressure transducer (Statham P23 Dc) used to measure the IOP was found to be affected by changes in the ambient temperature which occurred during compression and decompression. This may account for the changes in canine femoral IOP observed by others during similar experimental conditions.

Animals↗

The phenotype of ring chromosome 3.

A male child with mental retardation and poor growth was found to have a 46,XY,r3 (p26 leads to q29) karyotype in 92% of his peripheral lymphocytes and 90% of his cultured fibroblasts. Comparison of this patient's dysmorphic features with previously reported cases of ring 3 or deletion 3p suggests a clinical syndrome derived mainly from deletion of 3p26 leads to pter. The syndrome consists of mental retardation, pre- and postnatal growth retardation, microcephaly, hypertonia, digital anomalies, and a characteristic facies with ptosis, epicanthal folds, broad nasal root, down-turned corners of the mouth, and dysplastic ears.

Abnormalities, Multiple↗

Laser Doppler flowmetry and bone blood flow in an isolated perfused preparation.

A preparation of an isolated bovine forefoot was established which could be perfused with blood at variable rates. A laser Doppler flowmeter probe inserted into the cancellous bone of the metatarsal produced a signal which varied with changes in perfusion rate and oscillated in synchrony with the peristaltic perfusion pump. A stronger laser Doppler signal was obtained when the probe was inserted into a drill hole than when inserted into a hole bored with a guide wire. It appears that laser Doppler flowmetry has potential intraoperative use when the viability of bone is in question.

Animals↗