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Biomedical subjects

J Pooler

Publications and source records attributed to J Pooler.

8 recordsLinked to original sources

Factors affecting the outcome after proximal femoral fractures.

One hundred and forty-two consecutive patients with proximal femoral fractures were audited prospectively over a 1-year period. Mobility, age and sex were recorded along with timing of surgery, complications, 'will to live', length of admission, mortality, mobility and housing requirements on discharge. Operative procedures were performed mostly by intermediate surgical staff, on night-time emergency lists shared with other specialties. Patients were treated on a ward with nursing staff levels less than the minimum recommended by professional bodies. Mean hospital stay was 31 days. In-patient mortality was 37 per cent in males and 5 per cent in females. It was possible to predict protracted hospital stay in 84 per cent, mortality in 84 per cent, mobility on discharge in 92 per cent and need for rehousing in 83 per cent of patients. Of the 10 principal variables that affected outcome, four could be influenced by hospital practice. These variables were associated with 1284 hospital bed days, which constituted 30 per cent of total bed occupancy. Fifty-five per cent of these were associated with non-medical delay to surgery, 25 per cent with wound infection or re-operation and 20 per cent with broken pressure areas. There would appear to be the potential to improve outcome in proximal femoral fractures by stabilizing fractures within 24 h, adopting measures additional to antibiotic prophylaxis to reduce infection and ensuring that patients do not develop pressure sores.

Activities of Daily Living↗

Length of hospital stay and outcome after femoral neck fracture: a prospective study comparing the performance of two hospitals.

Length of hospital stay and outcome after femoral neck fracture were compared in a prospective study between two adjacent hospitals. In matched populations, mean length of stay was 30.8 days at Hospital X and 15.7 days at Hospital Y. Need for rehousing, age over 80 years and new nursing home placement prolonged length of stay at Hospital X, but not at Hospital Y. Hospital X had an orthopaedic rehabilitation ward and returned 88 per cent of patients to their own home, placing 9 per cent admitted from home in nursing homes. Hospital Y returned 76 per cent of patients to their own home and 19 per cent to nursing homes. The rapid discharge policy of Hospital Y saved significant resources within the acute hospital at the expense of returning significantly fewer patients to their own homes.

Aged↗

Modelling interprovincial migration using entropy-maximizing methods.

"The concern in this paper is with the prediction of population movements through the mathematical modelling of migration. In particular, the emphasis is on the testing of one of the most basic of a family of models of spatial interaction that have been developed in an information theoretic context in geography. Of special interest with this basic, totally constrained interaction model is the role of the distance variable in population migration and the extent to which it can be employed to predict Canadian interprovincial population migration flows."

Americas↗

Photodynamic alteration of sodium currents in lobster axons.

Photodynamic alteration of lobster giant axons drastically changed the magnitude and kinetics of sodium currents seen under voltage clamp using the sucrose gap technique. Illumination of axons following treatment with acridine orange or eosin Y decreased the maximum sodium conductance to a zero asymptote as an exponential function of illumination time. Normal sodium inactivation was slowed, with tau(h) more than doubled depending on experimental conditions. A second slower inactivation rate developed occasionally. tau(h) was altered little, if at all. Sodium current "tails" were not prolonged. At maximum light intensity and with eosin Y as sensitizer leakage current increased after 4-10 sec in light. These changes were irreversible. Decreases in maximum sodium conductance correlated highly with increases in time to peak sodium current. The magnitude of change varied linearly with light intensity. The action spectra for eosin Y and acridine orange peaked near 545 and 505 nm, respectively. The magnitude of change varied with preillumination dye exposure time in a quasi-exponential approach to a maximum effect. Sodium dithionite protected the axon from photodynamic change.

Acridines↗

Light-induced changes in dye-treated lobster giant axons.

Single giant axons from the lobster circumesophageal connective were studied using the sucrose gap voltage-clamp technique. The axon area in the gap was bathed in acridine orange for several minutes and then rinsed for several minutes. Subsequent illumination resulted in progressive prolongation of electrically stimulated action potentials to durations of 150 msec. The prolongation was accompanied by an increase in threshold. Currents in voltage clamp were altered such that transient current inactivation was greatly slowed. The turn on of transient current was somewhat slowed, the voltage at which peak transient current could be obtained was shifted to more positive internal potentials, and transient current at all potentials was decreased. Steady-state current was similarly affected. Low calcium following illumination partially counteracted some of the changes, but not the slowing of inactivation. Low calcium increased the duration of prolonged action potentials. Selective alteration of parameters in the Hodgkin-Huxley equations brought about a qualitative match between computations and data.

Acridines↗