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J Pommier

Publications and source records attributed to J Pommier.

107 records · Page 6Linked to original sources
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[Proceedings: In vitro thyroid hormone formation (author's transl)].

Iodination of a non halogenated goiter thyroglobulin and the resulting thyroxinogenesis was studied in vitro with purified thyroid peroxidase, H2O2 generating system and various concentrations of iodide. The rate of iodination was linear during the first minutes of incubation but thyroxine synthesis only began after a lag period whatever the iodide concentration in the incubation medium was. With high iodide concentrations a highly iodinated thyroglobulin (40-50 iodine atoms) containing no thyroxine was obtained after 3 minutes of incubation. If this highly iodinated goiter thyroglobulin was purified and reincubated with peroxidase and H2O2, thyroxine synthesis was again observed only after a lag period (2-3 min). In the absence of iodide the enzyme to elicit thyroxine synthesis. Depending of its concentration free diiodotyrosine exerts two opposite effects on the reaction catalyzed by thyroid peroxidase : at high concentration (10(-4) M) in inhibition of thyroglobulin iodination, and at low concentration (10(-7), 10(-8) M) a stimulating effect on thyroid hormones biosynthesis.

Diiodotyrosine↗
PubMedDate not supplied

[Medical prescription and consumption of psychotropic drugs: questions on the differences between men and women].

In health sociology and social epidemiology the gender-related differences in psychotropic drug consumption and prescription have not been throughly investigated. The objective of this review of literature is to analyze women's attitudes and behaviour in psychotropic drug consumption, the cultural influence of the patient's role in the doctor-female patient relation. The family, the society and the cultural aspects related to the role of the patient appear to be factors that strengthen the females' behaviour concerning psychotropic drugs. Results reflect that women consume more psychotropic drugs than men do; when they consult, they obtain them more frequently than men do; and doctors prescribe psychotropic drugs more often to women than to men. However many questions persist about the physicians' role: are the differences in prescriber's attitudes and practices related to their gender or to their patients' gender? Do women doctors prescribe more psychotropic drugs than male doctors? Do the former prescribe more to women than to men? If that is the case, what are the social and cultural reasons that account for this difference? Does a specific socialisation of the two genders account majoritarily for this difference?

Culture↗