Biomedical subjects

J Polich

Publications and source records attributed to J Polich.

136 records · Page 8Linked to original sources

PubMedDate not supplied

P300, stimulus intensity, modality, and probability.

Auditory and visual stimulus intensity were manipulated factorially with target probability to assess the influence of these variables on the P300 component of the event-related brain potential (ERP). Increases in stimulus intensity produced reliable increases in P300 amplitude and decreases in peak latency for both modalities that were additive with target stimulus probability effects. Similar, somewhat weaker stimulus intensity effects also were observed for the N100, P200, and N200 components. The findings suggest that stimulus intensity contributes to both P300 amplitude and latency measures in important ways and are discussed in relation to the use of ERPs in applied contexts.

Acoustic Stimulation↗

PubMedDate not supplied

P300 from one-, two-, and three-stimulus auditory paradigms.

P300 event-related potentials (ERPs) from 1-, 2-, and 3-tone oddball paradigms were elicited and compared from the same subjects. In the 1-tone paradigm, only a target tone was presented, with the standard tone replaced by silence. The 2-tone paradigm was a typical oddball task, wherein the target and standard tones were presented every 2.0 s in a random order with a target-tone probability of 0.10. In the 3-tone paradigm, in addition to the infrequent target (p = 0.10) and the frequent standard (p = 0.80), infrequent nontarget tones (p = 0.10) also were presented. The subject responded with a button press only to the target stimulus in each task. The target stimulus in each paradigm elicited a P300 component with a parietal maximum distribution. No P300 amplitude differences were found among paradigms, although peak latency from the 1-tone paradigm was shorter than those from the other two tasks. Both P300 peak amplitude and latency demonstrated strong positive correlations between each pair of paradigms. The results suggest that P300 was produced by the same neural and cognitive mechanisms across tasks. The possible utility of each paradigm in clinical testing is discussed.

Acoustic Stimulation↗

PubMedDate not supplied

P300 and the menstrual cycle.

Event-related potentials (ERPs) were elicited with an auditory discrimination paradigm in 20 adult female subjects on the first day of their menstrual cycles and approximately 14 days later. The amplitude and latency of the N1, P2, N2 and P3 (P300) components were measured for the two assessment times. No differences in either amplitude or latency for any of the components were observed as a function of menstrual cycle. Half the subjects who took oral contraceptives were compared to the other half who did not. No differences or interactions between these subgroups were obtained for any component amplitude or latency. It was concluded that menstrual cycle and use of oral contraceptives do not affect the P3 or other ERP components.

Adult↗

PubMedDate not supplied

P300 from a passive auditory paradigm.

The P300 (P3) event-related brain potential (ERP) was elicited with a passive tone sequence paradigm and evaluated in 2 studies. Experiment 1 compared ERPs from the passive procedure with those from an active discrimination (oddball) task. The passive sequence paradigm yielded P3 wave forms remarkably similar to those obtained from the active task since both demonstrated central-parietal maximum scalp distributions and virtually identical peak latencies. No differences between tasks were found when ERPs were elicited with subject's eyes open or closed. Experiment 2 compared ERPs from the passive sequence paradigm obtained when subjects were attempting to solve a word puzzle with those from a simple ignore condition. The puzzle-solving secondary task produced a decrease in P3 amplitude relative to the ignore condition, although P3 peak latency was unaffected. These results suggest that the passive sequence paradigm may be a useful and reliable means of eliciting the P3 ERP in subject populations or experimental situations in which an active discrimination task cannot be performed.

Adult↗

PubMedDate not supplied

P300 assessment of early Alzheimer's disease.

The P300 (P3) event-related brain potential (ERP) was elicited in 16 demented patients presumed to be in the early stages of Alzheimer's disease and 16 normal control subjects well matched for age, sex, education and occupational level. All subjects performed a simple auditory discrimination task in which a target tone was presented randomly on 20% of the trials. P3 amplitude was smaller and peak latency longer for the Alzheimer patients compared to control subjects. A second ERP task also was administered in which the target tone occurred 50% of the time. Analysis of the target/standard tone presentation sequences indicated that the Alzheimer patient group demonstrated less amplitude difference between the target and standard sequences and longer overall latencies compared to the control group. The results suggest that the P3 ERP component from auditory stimuli can provide useful information about Alzheimer's disease during its early stages.

Acoustic Stimulation↗

PubMedDate not supplied

P300 in young and elderly subjects: auditory frequency and intensity effects.

Auditory event-related potentials (ERPs) were assessed in young and elderly subjects when stimulus intensity (40 vs. 60 dB SL) and standard/target tone frequency (250/500 Hz and 1000/2000 Hz) were manipulated to study the effects of these variables on the P3(00) and N1, P2 and N2 components. Auditory thresholds for each stimulus type were obtained, and the stimulus intensity was adjusted to effect perceptually equal intensities across conditions for each subject. Younger subjects demonstrated larger P3 amplitudes and shorter latencies than elderly subjects. The low frequency stimuli produced larger P3 amplitude and shorter latencies than the high frequency stimuli. Low intensity stimuli yielded somewhat smaller P3 amplitudes and longer peak latencies than high intensity stimulus tones. Although additional stimulus intensity and frequency effects were obtained for the N1, P2 and N2 components, these generally differed relatively little with subject age. The findings suggest that auditory stimulus parameters contribute to P3 measures, which are different for young compared to elderly subjects.

Acoustic Stimulation↗

PubMedDate not supplied

When words collide: orthographic and phonological interference during word processing.

The interaction between orthographic and phonological information was studied in two experiments by requiring subjects to match visually presented word pairs on the basis of their visual or rhyming similarity. Word pairs either rhymed and looked alike, rhymed but did not look alike, looked alike but did not rhyme, or did not rhyme and did not look alike. In Experiment 1 under rhyme matching, reaction time (RT) was markedly increased whenever there was a conflict between orthographic and phonological cues. Under visual matching, overall RT was shorter than rhyme matching, with visually similar rhyming and non-rhyming pairs producing equally rapid and short responses compared to the non-rhyming but visually different word pairs. Most subjects also responded slower to rhyming and visually different stimuli compared to word pairs that did no look alike or rhyme. Experiment 2 sought to specify the processing locus of these effects by recording event-related brain potentials (ERPs) under task conditions similar to the first experiment. The RT data essentially replicated the effects found in Experiment 1 for both matching tasks. The ERP data viewed in the context of these results suggested that the interaction of the orthographic and phonological codes begins at least at the stimulus comparison processing stage, but that the conflict may also contribute to delays in response selection. The results are discussed in terms of several current models of word processing.

Discrimination Learning↗

PubMedDate not supplied

P300 seasonal variation.

The P300 (P3) event-related brain potential (ERP) was elicited with auditory stimuli in four different groups of normal, young adult subjects (n = 20 in each group) whose ERPs were obtained at different times of the year. P3 amplitude was largest during spring and summer and smaller for the subjects who were assessed during fall and winter. P3 latency was not affected reliably by changes in the seasons. Measurement of the daily sunshine present when each subject was recorded indicated that P3 amplitude is influenced by seasonal variation in the available amount of sunshine. These findings suggest that comparison of P3 amplitude across subject groups must take seasonal differences into account.

Adult↗

PubMedDate not supplied

P300 from normals and adult children of alcoholics.

The P300 event-related brain potential (ERP) was obtained from 24 pairs of undergraduate male subjects. One member of each pair reported having a father who was alcoholic (FH+), the other reported no alcoholic family member (FH-). Pairs were matched on height, weight, academic performance, and personal drinking history. Three auditory task situations were employed which manipulated stimulus discrimination difficulty. All tasks employed 20% target and 80% standard tones randomly presented with the subjects required to move their index finger whenever a target tone was detected. No differences in P300 amplitude or latency were obtained between the groups. FH+ subjects tended to demonstrate decreased amplitudes with increased amounts of reported alcohol consumption but only for the most difficult task. The results of the present study suggest that the relationship between the P300 and the heritability for alcoholism is not yet clear and may be modulated by differences in task requirements, subject populations, and personal drinking history.

Adolescent↗

PubMedDate not supplied

Long latency auditory evoked potentials: intensity, inter-stimulus interval, and habituation.

Experiment 1 elicited the P1, N1, P2, and N2 components of the long latency auditory evoked potential (AEP) using a 1000 Hz tone presented at 30, 50, or 70 dB SPL and 1-, 3-, or 5-second inter-stimulus intervals to assess the relative effects of the combination of these variables on component amplitude and latency. Four blocks of 16 tone presentations each were recorded from each subject to determine if changes in the AEP would occur because of short-term habituation. Both stimulus factors interacted significantly in a systematic fashion for the amplitude measures, with increases in latency also associated with increases in intensity and inter-stimulus interval. Only minor changes across the four trial blocks for either the amplitude or latency measures were observed over the various stimulus presentation conditions. Experiment 2 employed the same tone stimulus presented at 50 dB SPL and a 3-second inter-stimulus interval. Eight blocks of 64 trials were recorded from each subject on each day for four days to investigate long-term habituation effects. No substantial changes in any of the component amplitudes or latencies were obtained across the 32 trial blocks. It was concluded that intensity and inter-stimulus interval interact to determine AEP amplitude as well as latency values and that the constituent components do not change appreciably with repeated stimulus presentations, even after several days.

Electroencephalography↗