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Biomedical subjects

J Pleines

Publications and source records attributed to J Pleines.

13 recordsLinked to original sources
PubMed1993

[Nursing care evolves? That's to be seen!].

This author sees a gap between nursing education and practice. She maintains that critical thinking and analysis of a nursing situation are part of the autonomous functions of a professional nurse. She also believes that nurses at the masters level should not only teach patients and their families, but also new nursing graduates in order to give them an inservice preparation to critical thinking. The author also suggests that new grads receive a supervised internship.

Education, Nursing↗
PubMed1992

The increased susceptibility of women to multiple sclerosis.

Many diseases with an auto-immune etiology have a skewed sex distribution. In the majority of instances, women are affected more frequently than men. A review of population studies demonstrates that the preponderance of women in multiple sclerosis (MS) is almost constant. We show that this preponderance is further increased in early as well as in late-onset cases, in familial cases as well as in MS twin pairs and that the HLA-DR2 allele, which has been associated with MS in Caucasian populations, is significantly more frequent in women than in men with MS. "Rules" have been established for multifactorial diseases; MS contravenes most of those rules. The skewed sex distribution in MS could be attributed to the known hormonal and gender influences on the immune response, as well as to genetic influences.

Diseases in Twins↗
PubMed1991

[Mild psychosomatic illnesses].

Referring to our August article on psychosomatic illness, the author states that there are harmless forms of this disorder that nearly everyone, including nurses, experience at some point in their lives. Early awareness is an important step toward defusing potentially harmful psychosomatic problems.

Humans↗
PubMed1987

Multiple sclerosis in childhood: clinical profile in 125 patients.

Multiple sclerosis (MS) has its usual onset in early adult life (average age of 30 years), but age at clinical onset varies considerably. The implications of the age of onset on the clinical presentation and course of MS are unclear. This population-based retrospective study presents data from a group of 125 patients with onset of MS before age 16 years and can thus be considered as representative of MS occurring in childhood. It demonstrates that childhood MS is more frequent in girls, that it very often has a relapsing-remitting course, that initial bouts usually involve afferent structures of the central nervous system, that recovery from these is often complete, and that the pace of the disease is slow.

Adolescent↗
PubMed1987

Clinical and sleep laboratory study of narcoleptic symptoms in multiple sclerosis.

Seventy white patients with a diagnosis of MS and typed for their HLA-A, B, C, and DR were studied. A clinical interview and a questionnaire were used to evaluate the presence of narcoleptic symptoms. The prevalence of sleep attacks, cataplexy, and sleep paralysis was significantly elevated among these patients. However, no difference was seen between DR2 and non-DR2 subjects with regard to the incidence of narcoleptic symptoms. Nine DR2 patients complaining of both sleep attacks and cataplexy were studied in the sleep laboratory for five consecutive naps, but no polygraphic evidence of narcolepsy was found.

Adult↗
PubMed1985

Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression.

We have examined the distribution of HLA antigens in 70 multiple sclerosis (MS) patients divided in three groups defined according to clinical criteria: benign MS, severe MS, cerebellar MS. We have found a significant association between severe MS and HLA-DR2, and between benign MS of more than 15 years of evolution and HLA-DR3. We review previous work along the same line and conclude that the association of HLA antigens with "clinical subgroups of MS" could indicate a genetically based heterogeneity of the disease and offer help in establishing a prognosis.

Cerebellar Diseases↗
PubMed1985

Isoniazid for tremor in multiple sclerosis: a controlled trial.

We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there was a high percentage of "slow acetylators"; dosage was reduced by one-half in five patients. Improvement was mild and did not result in significant functional improvement.

Adult↗
PubMed1979

Estimation of cardio-pulmonary function by means of the age equivalent.

Many of the cardio-pulmonary function variables depend on age showing a deterioration with increasing age. Reversing this relationship age can be estimated by cardio-pulmonary variables. In the present study, age was estimated using a multiple regression equation including variables measured at rest and at exercise. The difference between estimated and chronological age is called the age equivalent. (delta A). Formulas for estimating delta A have been established in 59 strictly defined normal subjects and applied on groups of athletes, smokers and foundry workers. Using the delta A, factors such as physical fitness, smoking habits, heaviness of work and dust exposure can be discriminated. It is concluded that the age equivalent is more useful in epidemiological surveys than in individual analysis of functional capacity. The age equivalent may be an approach to data reduction in cardio-pulmonary function analysis.

Adult↗
PubMed1970

[A dream hospital].

Explore the source record for details and available documents.

Hospitals, General↗