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J Planas

Publications and source records attributed to J Planas.

114 records · Page 7Linked to original sources
PubMedDate not supplied

Usefulness of prostate-specific antigen nadir as predictor of androgen-independent progression of metastatic prostate cancer.

The objective of this study was to analyze the value of the nadir level of prostate-specific antigen (PSA) to predict androgen-independent progression (AIP) in metastatic prostate cancer patients after androgen deprivation therapy. In a group of 185 metastatic prostate cancer patients who received androgen deprivation therapy serum PSA was determined every three months until AIP occurred. Multiple regression analysis was performed to define independent clinical and PSA-related predictors of AIP. AIP was assumed to be present after two consecutive increases in serum PSA after the PSA nadir. Independent predictors of the duration of AIP-free survival (less than 12 months versus more than 12 months) were the extent of bone involvement (six or fewer hot spots versus more than six) with an odds ratio (O.R.) of 3.95, Gleason score (7 or less versus more than 7) with an O.R. of 3.47, and PSA nadir (2 microg/L or less versus more than 2 microg/L) with an O.R. of 14.63. AIP was independently predicted by the extent of bone involvement with an O.R. of 1.72, Gleason score with an O.R. of 1.74, PSA nadir with an O.R. of 3.22, and time to reach the PSA nadir (9 months or less versus more than 9 months) with an O.R. of 2.84. When patients were stratified according to these predictors, those with three good prognostic factors had a median AIP-free survival of 58 months while those with two, one or no good prognostic factors had a median AIP-free survival of 19 months, 12 months and 7 months, respectively. We conclude that the PSA nadir seems to be a good predictor of AIP in patients with metastatic prostate cancer after androgen deprivation therapy. Time to PSA nadir, extent of bone involvement and Gleason score are also independent predictors. The combination of these prognostic factors allows to stratify metastatic prostate cancer patients for the prediction of AIP.

Adult↗
PubMedDate not supplied

[The symptom-diagnosis interval: a possible approximation to the natural history of neoplasms].

In order to assess the influence that age, sex, site of the primary tumor (SPT), the extension and histology may have on the interval first symptom-diagnosis (ISD), 1.149 cases of lung, breast, stomach, colon and rectum cancer registered in the Tumor Registry of the Hospital del Mar (Barcelona) were analyzed. Overall, mean ISD was 5.7 months. 12.7% of women and 5.5% of men (p less than 0.0001) had an ISD greater than one year. Age does not appear to influence ISD in this population (r = 0.014). Among women, the ISD for each SPT was as follows: breast cancer, 9.1 months; rectal cancer, 6.5; stomach, 4.9; colon, 4.7; lung, 2.7. Men's ISD were: rectum, 6.2; stomach, 5.9; colon, 5.7; lung 3.2. Age, sex, SPT, the extension and histology jointly explain only 18% of the ISD variability (multiple r = 0.42 p less than 0.0001). SPT and histology appear to be the strongest predictors, both remaining statistically significant when adjusting for the other four factors. While only breast cancer clearly showed a positive association between ISD and tumor extension, an unexpected inverse relationship was observed in rectal cancer. In some tumors, the ISD may just be an indicator for the rate of tumor growth. ISD data registered in a Tumor Registry can contribute to the study of a part of the natural history of neoplasms. Such analyses are also relevant for studies of secondary prevention and screening programs, access to and quality of care, and psychosocial predictors of the care seeking process.

Adult↗
PubMedDate not supplied

Hematological parameters and iron metabolism in pigeons and chickens with phenylhydrazine-induced anemia.

A single phenylhydrazine injection (1.8 mg/kg body weight in chickens and 2.2 mg/kg body weight in pigeons) was administered intramuscularly to different lots of animals. The modification of hematocrit, hemoglobin, erythrocyte number, reticulocyte concentration, plasma iron, and total iron-binding capacity was monitored versus time. Depression of the hematological parameters in chickens was greatest on the second day (27-40%), and the values returned to normal by day 7. The drop in pigeons was greater (28-51%) and took longer to return to normal (day 22). The highest percentage of reticulocytes was 35-37%. A plasma iron increase was concomitant to cell destruction and decreased later. The plasma iron clearance values showed a double slope line as a result of the presence of reticulocytes. A high correlation existed between iron uptake by red blood cells at 5 min and the reticulocyte concentration. The responses of the two species to the phenylhydrazine were similar, and differences were more quantitative than qualitative. Reticulocytes were present in normal pigeons, which introduces an important variant in iron metabolism in birds.

Anemia↗