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Biomedical subjects

J Pizzuto

Publications and source records attributed to J Pizzuto.

At least 55 records · Page 3Linked to original sources
PubMed1978

Detection of urinary fibrin-fibrinogen degradation products in kidney transplantation.

Several techniques are used to detect rejection episodes in renal transplants; complexity renders these tests impractical for clinical use in most cases. This paper reports the results obtained in the study of urinary FDP, by counterimmunoelectrophoresis, in 50 healthy subjects and in 360 consecutive samples from 18 renal transplant recipients; urine specimens were examined daily for periods of time of up to 60 days post transplant. Endogenous creatinine clearance levels were also quantified. Our findings show that while in normal subjects negative tests were always obtained in kidney transplant patients, increased FDP excretion was found, with peak levels observed at least 24 hours before the decrease of glomerular filtration rates and clinical manifestations of acute rejection which subside with immunosuppression. Finally, urinary FDP excretion in the oliguric phase of post transplant acute renal failure was similar to that of patients where kidney transplants functioned without any evidence of rejection.

Acute Kidney Injury↗
PubMed1975

[Hypercoagulability in the nephrotic syndrome of children].

Several coagulation factors were studied in twenty children less than 16 years old, bearing nephrotic syndrome. Four of them were in remission. In nephrotic syndrome there is hypercoagulability. Coagulations factors such as fibrinogen, platelet factor III, prothrombin time, and factor V are markedly altered, and to a lesser degree, total number of platelets. Fibrin degradation products factors II, VII, X and VIII are also altered. During remission, all of them improve or become normal. In no case fibrin breakdown products were found in the blood. However, if found in urine, they would be considered as a pronostic index in nephropaties. Although etiologic factors remain unknown for most of the above-mentioned alterations, increased fibrinogen synthesis, decreased fibrinolytic plasms activity and renal damage have been demonstrated.

Adolescent↗