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Biomedical subjects

J Piotrowski

Publications and source records attributed to J Piotrowski.

212 records · Page 12Linked to original sources
PubMedDate not supplied

[The course of liver cirrhosis not preceded by viral hepatitis with p articular reference to toxic etiology].

The study was aimed at analysing the epidemiological structure of patients with liver cirrhosis without HBsAg treated in 1980-1988. There were 231 of such cases in this period of time. The most frequent cause of liver cirrhosis in patients under 60 years of life was chronic alcoholism whereas 40% of the diagnosed liver cirrhosis in older persons was of unclear etiology. Patients complaints, clinical examinations, and results of the laboratory tests were analysed. The course of the disease was more severe in alcohol-produced liver cirrhosis leading to the haemorrhage from esophageal varices in 36%, and coma in 8% of cases. Alcohol-produced liver cirrhosis promoted other complications such as: cancer of the liver, hepato-renal syndrome or encephalopathy. Liver cirrhosis of unclear etiology in the elderly may be a consequence of the prolonged exposition to environmental pollutants. More severe course of alcohol-produced liver cirrhosis may depend on simultaneous action of two harmful factors: alcohol and environmental pollutants.

Adult↗
PubMedDate not supplied

[Evaluation of microsomal liver enzyme function in patients with duodenal ulcer treated with ranitidine].

Functioning of hepatocytes has been assessed with respiratory test with aminopyrine labelled with 14C radioisotope in patients with duodenal ulcer treated with ranitidine. Reversibility of changes in liver microsomal system at different intervals after the completion of therapy has also been evaluated. Altogether 30 patients with duodenal ulcer treated with ranitidine have been examined: prior to the treatment--group Ia, after one day of ranitidine administration--group Ib, within 4 weeks of therapy--group Ic, within 8 weeks of therapy--group Id, and one week after the completion of the treatment--group Ie, as well as after a 4-week follow-up period--group If. Significant decrease in the results of respiratory test has been noted in patients treated with ranitidine after both four and eight weeks. Activity of liver mono-oxidases approached baseline values after one week following the completion of therapy. The results of routine liver functioning tests in all patients of groups I and II have been within normal values. The obtained results suggest that patients treated with ranitidine should cautiously be given other medicines, especially those affecting liver functioning or metabolized in the liver.

Adult↗