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Biomedical subjects

J Petres

Publications and source records attributed to J Petres.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Moist wound treatment with ointment dressings in surface skin defects].

The advantages of moist wound treatment by means of ointment gauze dressing are based on the following attributes of the marked tulle gras preparations: --easy to handle; storage without problem --the gauze dressings can be modeled easily even on difficult body contoures (for example in the face) --the gauze dressing can be changed easily --Synthetic tulle gras dressings do not fray so that no residues remain in the wound. Therefore the danger of adhesion with the wound can be minimized. --There is no congestion of secretions undermath the gauze dressing. --undisturbed healing: a presupposing factor for optimal cosmetic and therapeutic result. --Minimal danger of contact dermatitis by using paraffin gauze dressing without antiseptic additives.

Bandages↗
PubMed1988

[Pedicled flap-plasties].

Pedicle flaps are performed within the operative dermatology basically to close larger operation defects following surgical excision of malignant skin tumors. It is a fact, that more than 3/4 of these skin tumors are located on the head and the cervical region. Especially in this area local and regional flaps guarantee a functionally and aesthetically satisfying reconstruction of the excised structures. As a matter of fact the basic methods of pedicle flaps as the transposition and the advancement-flaps are known for more than a hundred years. In the meantime the techniques were merely refined and modified, so that even extended skin and soft-tissue defects can be closed without compromising on radicality. Based on broad own experience the indication and the application of these techniques are described. Possible risks are demonstrated which can arise by disregarding anatomical and morphological conditions.

Facial Neoplasms↗
PubMed1986

[Preventive lymphadenectomy in cutaneous malignant melanomas. A matched pair study].

Data on 70 patients with melanomas classified as clinical stage I, who had been treated surgically with wide excision (n = 49) or wide excision plus prophylactic lymph node dissection (n = 21) at the University Dermatology Clinic, Freiburg i. Br. between 1975 and 1977, were reviewed in a retrospective study. The effectiveness of elective lymph node dissection was examined by creating 21 pairs of patients, matched according to sex as well as to the level, location and thickness of the tumors (to within +/- 5%). One patient in each pair underwent wide local excision and prophylactic lymph node dissection (WE + PLND) to others did not (WE only). Depending on tumor thickness there was a better chance of survival for the PLND patient group. However, these differences were not statistically significant.

Female↗
PubMed1985

Prevention of recurrences in frequently relapsing herpes labialis with thymopentin. A randomized double-blind placebo-controlled multicenter study.

The present randomized, placebo-controlled double-blind multicenter study included a population of 36 subjects with frequent recurrences (at least once a month) of herpes labialis. Most of the patients had failed to respond adequately to previous treatment with other therapeutic tools, including acyclovir. Either 50 mg of thymopentin or of placebo was administered 3 times a week, by the subcutaneous route, for 6 weeks. Subsequently, the patients were observed for nearly 6 months on the average. The results achieved with thymopentin for the individual parameters were significantly superior to those obtained with placebo; thus significant improvement was seen in patients on thymopentin in the duration of the longest symptomfree period (prolonged from 2.1 weeks to 20.9 weeks, p = 0.000), in the number of relapses (reduced from 1.6 to 0.4 episodes/month, p = 0.001), and in the total duration of herpes symptoms per month (shortened from 2.0 to 0.3 weeks, p = 0.000). Placebo treatment also resulted in considerable improvement (p less than 0.05 or 0.01), but was significantly inferior to the improvement obtained with thymopentin. The longest symptomfree period in the placebo group was prolonged from 2.4 to 11.2 weeks. The number of relapses per month was reduced from 1.4 to 0.8, and the total duration of herpes symptoms per month from 2 to 0.9 weeks. The results of intergroup analyses, in which the observed parameters and the improvement achieved in either group were compared, significantly favored thymopentin treatment. The effect of thymopentin was in all but one parameters superior to that of placebo and highly significant (p less than 0.01).

Adjuvants, Immunologic↗
PubMed1985

[Therapy of rhinophyma].

Treatment of rhinophyma is successful only with surgical methods. The operative techniques described in the literature are discussed critically and decortication is the method of choice. When this technique is applied, the hyperplastic nasal tissue is removed down to the basal parts of the sebaceous glands. This causes spontaneous re-epithelization of the skin surface without scarring. Methods using deeper excision and plastic surgical repair of the defect by skin grafting or pedicled flaps are cosmetically inferior to the method of decortication. Whatever the method, however, histopathological examination of the excised rhinophyma tissue is necessary in order to exclude malignant growths, such as basal cell or squamous cell carcinomas, which are frequently seen in rhinophyma.

Aged↗
PubMed1985

[Temporary covering in the surgery of skin tumors].

The experienced dermatologist knows how to use SYSpur derm and Epigard, respectively, according to their individual indication spectra. We are of the opinion that SYSpur derm is chiefly indicated for temporary covering after tumor excision until definite reconstruction by flaps or, occasionally, by primary surgical suture, because of its minor adhesion to the granulation tissue. Epigard, in contrast, bears essential advantages with regard to the conditioning of the wound ground. As the granulations grow rapidly into the highly permeable polyurethane foam of Epigard which has to be changed frequently, a regular lawn of granulations is induced, similar to that after superficial abrasion with the sharp spoon (dermatologic curet). In addition, this technique brings on optimum conditions for the settling of grafts without any difficulties.

Aged↗
PubMed1984

Histology of congenital nevi during the first year of life. A study by conventional and electron microscopy.

We studied 14 biopsies of congenital melanocytic nevi of children up to 1 year of age. In 11 biopsies we found two different types of melanocytic cells. In the reticular dermis, they were small cells. They had small nuclei, little cytoplasm, and no detectable pigment. They did not come in nests, but were scattered between the collagen bundles. The other type of cells was found within the epidermis or closely under it. These cells were large and round, and had abundant cytoplasms and evenly distributed melanin. Sometimes these cells were arranged in nests and in two moles they were also found in the epithelia of follicles. In all of these biopsies (with three exceptions) the superficial, large pigmented cells were separated from the deep, small, nonpigmented ones by a zone of tissue without any melanocytic cell. Early in life both types of cells are clearly separated, and the superficial ones are few. At later ages the superficial large cells are found in increased numbers, whereas the number of the deep ones does not change with age.

Biopsy↗
PubMed1983

[Relevance of an iodine allergy to commercial polyvidone-iodine preparations].

Patch testing with Iodine/potassium-iodide (3%) and commercialized povidone (PVP)-iodine preparations (Betaisodona-ointment and solution, Polyvidon-Jod-ointment "Braun", Braunol-solution "Braun", Traumasept-ointment, and Traumasept solution--not marketed--, were carried out in 104 patients of the Department of Dermatology of the Municipal Hospital Kassel. In addition, the according ointment and solution-bases were tested. 22 tests were patients with ulcera crurum, 82 patients with infectious skin diseases or skin tumors. 35 out of the 104 patients showed positive reactions to iodine/potassium-iodide. Hyperreactivity to one or more PVP-iodine-ointments was found in 12 patients, to one or more PVP-iodine solutions in 29 patients. If there was no positive reaction to iodine/potassium-iodide, PVP-iodine ointments were always tolerated, while PVP-iodine-solutions produced positive reactions in 9 cases even then. Our results show that allergic skin reactions must be expected in 2-9% of all patients using PVP-iodine ointments, and in 12-20% of all patients using PVP-iodine-solutions. If iodine-allergy is known the rate of positive reactions to PVP-iodine ointments is 6-25% to the solutions 34-60%.

Drug Hypersensitivity↗
PubMed1982

[Free skin transplants. Method for the optimization of the operations].

A historical survey precedes a discussion about the possibilities and limitations of free skin grafting. Although full thickness skin grafts are more resistant than split-thickness grafts, these are less demanding to the recipient site. In severe surgical defect wounds the wound bed should be conditioned using synthetic skin substitute Epigard prior to final wound closure. By using this temporary synthetic skin substitute the development of granulation tissue is being controlled. In an effort to optimize the adaptation of the graft on the wound surface, a technique of our own is being introduced. If the bordering granulation tissue at the wound edge is beveled by means of a high-speed milling cutter at an angle of 30 degrees, an equal-levelled adaptation is achieved.

Humans↗
PubMed1981

[A very promising treatment method in psoriasis. Short-term anthralin therapy].

UNLABELLED: New found knowledge concerning the penetration kinetics of anthralin induced us to modify the treatment of psoriasis. The new method was compared in a right-left test with the classical anthralin therapy in 9 patients. After that the entire body was treated with the short-term therapy on 45 patients with severe psoriasis. METHOD: once a day 1%-anthralin-5%-salicylic acid vaseline was rubbed over all parts of the skin and after 10 minutes washed off thoroughly. Within a few days the dosage was increased up to 3% anthralin and the application time up to 20 minutes if possible. The treatment was continued on the level according to the individual tolerance. With the new method there was an earlier healing process and the time of treatment was therefore shortened. Moreover after a few days of hospitalization it was possible to continue the treatment at home with cooperative patients, able to go on with their work. Short-time anthralin therapy seems to optimate the classical method.

Administration, Topical↗
PubMed1978

Synergistical effects of ficoll and phytohemagglutinin on human lymphocytes.

The influence of increasing concentration of the highly polymerized dectran Ficoll on cultured peripheral human blood lymphocytes stimulated or not stimulated by PHA was studied. The incorporation of 14C-thymidine into acid-insoluble material of unstimulated lymphocytes has not been influenced in the presence of increasing concentrations of Ficoll either pretreated with chelating resin or not pretreated. Ficoll not pretreated with chelating resin potentiates the PHA-induced stimulation by the factor 4.3 at 0.1 mg Ficoll/ml culture medium, and by the factor 3.2 at 1.0 mg/ml when PHA stimulated HPBL were used. Ficoll after pretreatment with chelating resin does not influence the DNA-synthesis at 0.1 mg Ficoll/ml medium, but causes a drop of the incorporation of 14C-thymidine by the factor 2.0 at 1.0 mg/ml. Using 10.0 mg per ml, both Ficoll preparation cause a decrease of the DNA-synthesis by the factor 2.5--3.0--probably a cytotoxic effect. The results obtained with emission spectrographic analysis and conductivity measurements show, that Ficoll after treatment with chelating resin contains about 10 times more ions (Mg, Ca, Na, Si) and has a 3.2-fold higher conductivity then Ficoll without pretreatment. It is possible that phenomena like electrochemical changes on the surface of the lymphocytes and osmotic alterations in the culture medium are responsible for these effects.

Cells, Cultured↗
PubMed1978

The nasolabial flap for reconstruction of the alae nasi.

Cicatrizing basal-cell carcinomas, especially in the area of the alae nasi, require radical therapeutic treatment. Surgical removal, therefore, often results in penetrating defects. The nasolabial flap is recommended in such cases as a relatively simple operative method of reconstructing the lateral part of the nose. This technique offers favorable results in a curative and esthetic respect.

Basal Cell Carcinoma↗
PubMed1978

[Surgical treatment of hyperhidrosis axillaris].

Radical sweat gland excision is the treatment of choice in axillary hyperhidrosis. After a review of the common surgical techniques the own technique is discribed. It consists of a vertical excision of the hyperhidrotic skin area and primary wound closure. No recurrences of hyperhidrosis were seen in the follow up period.

Adult↗
PubMed1978

[Florid oral papillomatosis. A contribution to cytostatic therapy].

Based on the recent clinical experience in treating florid oral papillomatosis (FOP), the only successful therapy appears to be the use of cytostatic agents. The case report of a patient with clinically and histologically confirmed FOP is described to emphasize the advantages of administering Bleomycin intra-arterially (external carotid artery) by means of a Holter catheter. This catheter is used to release pressure in the treatment of internal hydrocephalus and is designed to remain in place for a number of years. The successful treatment of FOP points out the possibility of employing a Holter catheter for administering cytostatic agents in the treatment of malignant neoplasms in the facial area. Cytophotometric examinations of the prickle cells within the FOP mass showed a diploid pattern of DNA distribution similar to that of benigh tumors. However, it is not possible to definitely establish the malignant or benign nature of FOP in this manner.

Alopecia↗
PubMed1977

Effects of arsenic cell metabolism and cell proliferation: cytogenetic and biochemical studies.

Chromosome analysis of lymphocytes from patients who had been exposed to arsenic showed frequent structural and numerical aberrations, even with an interval of decades since the last exposure. The in vitro addition of sodium arsenate induced the same chromosome changes--even to extreme of chromosome pulverizations--upon lymphocyte cultures from healthy subjects. Radioactive incorporation studies showed that arsenate was able to inhibit dose-dependently the incorporation of radioactively labeled nucleotide in RNA and DNA. Beyond that, arsenic blocked the cells in the S- and G2-phase. A general explanation for the inhibitory effect of inorganic arsenic on cell metabolism is the known strong affinity of arsenic to enzymes, especially to those containing sulfhydryl groups.

Aged↗