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Biomedical subjects

J Perron

Publications and source records attributed to J Perron.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Cutaneous lesions induced by long-term use of hydroxyurea].

The authors report 3 cases of patients having myeloid chronic leukemia presenting skin changes after long-term hydroxyurea therapy. Some of these side effects are already known; such as dryness, pigmentation, spontaneous necrotizing ulceration and chromonychia with longitudinal pigmented bands. Two new signs are described: a band-like erythema on the dorsum of the fingers and toes, as in dermatomyositis and a plantar keratoderma which interpretation is difficult in such a context. The hydroxyurea's imputability is discussed. These lesions altogether are very suggestive of skin changes after hydroxyurea therapy. The occurrence of such phenomena is quite frequent.

Aged↗
PubMed1981

[Lichen planus with linear IgG and C3 deposits at the dermal-epidermal junction (author's transl)].

Report of 4 cases of clinically and histologically typical lichen planus with a linear IgG and C3 deposit at the dermal-epidermal junction in involved (4/4) and healthy (2/2) skin, as detected by direct immunofluorescence. Indirect immunofluorescence was negative (3/3). In these 4 cases, the clinical aspect was different: there were no vesiculo-bullous lesions in case 1; case 2 and 3 were of the partly vesicular type with dermal-epidermal separation only in the involved skin; in case 4, bullae were present on both healthy and lesional skin. This suggests that there might exist a broad spectrum ranging from lichen planus without clinical vesiculo-bullous lesions, but with linear IgG and C3 deposits, to lichen planus associated with clinical, histological and immunological symptoms of bullous pemphigoid.

Adult↗
PubMed1979

[Non suppurative acute "bacterial" pneumonia in alcoholics. Study of 54 cases (author's transl)].

Pneumonia in alcoholics are frequent and often severe. A retrospective study, including two groups of patients, 25 in internal medicine and 29 in intensive care, was undertaken to define the main clinical, prognostic and therapeutical characters of these pneumonias. Death rate was very high in patients admitted to intensive care units (60%) but nil in patients in internal medicine. The principal elements of the prognosis were the existence of a neutropenia at the beginning, the condition of denutrition of the patient, failure to recognize the responsible germ because of an antibiotic treatment given blindly, and the delay of the treatment. The pneumococcus was the most frequently encountered germ (77%). After discussing the mechanisms of the quantitative and qualitative involvement of the neutrophilic leukocytes, the authors stated the measures which would lower the death rate and stressed the value of transtracheal puncture enabling an early bacteriological diagnosis.

Acute Disease↗
PubMed1975

Segmental urethrectomy and urethrorrhaphy for treatment of fresh and late traumatic urethral lesions.

For 16 years we have used segmental urethrectomy with end-to-end urethrorrhaphy for treatment of traumatic urethral lesions, in preference to two-stage urethroplasties. The approach has been transperineal, retropubic, and if necessary transpubic. Good results in 41 cases with long-term follow-up allow us to say that this is a good operation. It provides in two thirds of the patients a correct and stable urethral stream, complete bladder emptying, and does not affect urinary control or sexual function if this was normal following the injury.

Adult↗