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Biomedical subjects

J Perrin

Publications and source records attributed to J Perrin.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Prevalence of hepatitis C virus infection in Africa: anti-HCV antibodies in the general population and in patients suffering from cirrhosis or primary liver cancer.

Anti-hepatitis-C-virus (anti-HCV) antibody was tested for in sera from 410 adults living in Tunisia, Senegal, Burundi and Madagascar, and in 209 Tunisian and Senegalese patients suffering from liver diseases. Anti-HCV antibodies were detected in 4.2% of the adult population from Africa, in 51% of patients suffering from liver cirrhosis and in 37% of patients suffering from primary liver cancer. However, higher proportions of anti-HCV antibodies were detected in HBsAg+ patients than in HBsAg- patients. To assess the role of HCV in the development of both cirrhosis and primary liver cancer, a confirmation test is needed.

Africa↗
PubMedDate not supplied

[First results of a longitudinal survey upon the small airways disease].

Five years after a cross-sectional survey concerning the small airways disease within a working population aged 18 to 66 years, the authors carried on a new study within the same sample of population (272 subjects) using the same methodology of research : standard questionnaire and spirometry (VC, FEV1, FEV1/VC, MEF 25-75/VC). The goal of this study was to assess the functional outlook of the individuals depending on the functional status recorded in the frame of the first study, i.e. normal ventilatory status, small airways disease, advanced bronchial obstruction. The results showed that after five years there is a worsening of the ventilatory status, mostly in men and in aged persons at start. This worsening arises from the movement from one category to another towards the advanced bronchial obstruction. This movement was reversible from small airways disease to normal status. Conversely, the movement from small airways disease to advanced bronchial obstruction was irreversible. This study shows that small airways disease is an intermediate condition between normal status and advanced bronchial obstruction. Three risk factors were put in evidence both for small airways disease and for movement towards advanced bronchial obstruction : male sex, aging and tobacco smoking.

Adolescent↗
PubMedDate not supplied

[Epidemiology and pathologic results of chronic carriers state of hepatitis B in Mali].

The HB antigen of the hepatitis B (HB) virus, studied by counter immunoelectrophoresis shows a prevalence of 8.7% in 1,860 rural Malians and 11.3% in 764 blood donors from Bamako. Amongst 1,350 hospitalised patients, no correlation could be established between the HBs antigen chronic carriers state and other infectious diseases, malnutrition or genetic deficiencies. On the other hand, the prevalence of HBs antigen is particularly high in hepatic infections: acute and chronic hepatitis (53.5%), cirrhosis (31.5%) and hepatomas (25.3%). The study of the prevalence of hepatitis B by radioimmunoassay of the HBV seric markers was carried out in: --176 "healthy" town dwellers of which 97.2% were carriers of at least one marker--HBs Ag: 16.5%; anti-HBc alone: 34.1%; anti-HBs: 46.6%--. --30 subjects with cirrhosis--HBs Ag: 66.7%; anti-HBc alone: 10.0%; anti-HBs: 23.3%--. --42 subjects with PHC--HBs Ag: 47.6%; anti-HBc alone: 23.8%; anti-HBs: 28.6%--. The difference in HBs Ag carrier state between patients (cirrhosis and PHC) and controls, cross-matched for sex and age, is highly significative--p = 0,0001--.

Adolescent↗