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Biomedical subjects

J Pennington

Publications and source records attributed to J Pennington.

32 records · Page 2Linked to original sources
PubMed1987

Sulfur-dioxide-induced bronchitis in dogs. Effects on airway responsiveness to inhaled and intravenously administered methacholine.

Chronic bronchitis was induced in 7 dogs of mixed breed by chronic exposure to SO2 gas. Within the first 2 to 4 wk of exposure, the dogs developed cough and mucous hypersecretion, chronic airway obstruction (increased pulmonary resistance), and persistent lung inflammation as demonstrated by an increase in the number of neutrophils recovered in the bronchoalveolar lavage (BAL) fluid. Airway responsiveness to methacholine aerosol decreased 2- to 3-fold within 8 wk of SO2 exposure. In contrast, airway responsiveness to intravenous administration of methacholine did not change. The data suggest that the decreased airway responsiveness observed during persistent pulmonary inflammation in SO2-exposed dogs is not due to an altered state of airway contractile elements but likely reflects expression of an inhibitory influence of the mucoepithelial barrier.

Airway Resistance↗
PubMed1983

High-molecular-weight glycoproteins are the major carriers of the carbohydrate differentiation antigens I, i and SSEA-1 of mouse teratocarcinoma cells.

The carriers of the carbohydrate differentiation antigens I, i and SSEA-1 were investigated in embryonal carcinoma cell lines of mouse and differentiated cell lines derived from them. Glycoproteins were studied by immunostaining ('Western blotting') of total cell lysates and immunoprecipitation from lysates of galactose oxidase/NaB3H4-labelled cells; glycolipids were investigated by immunostaining of thin layer chromatograms. The antigenic activities detected by immunofluorescence of cell smears were reflected in the antigenicities of high-molecular-weight glycoproteins. These were polydisperse and markedly susceptible to digestion with endo-beta-galactosidase. Only the I antigen was detected on minor glycolipids. These observations indicate that glycoproteins rather than glycolipids are the major carriers of carbohydrate differentiation antigens I, i and SSEA-1 in the teratocarcinoma cell lines.

Animals↗
PubMed1982

Horse anti-type XIV Pneumococcus sera behave as cold agglutinins recognizing developmentally regulated antigens apart from the Ii antigens on human erythrocytes.

Haemagglutination studies with horse anti-type XIV pneumococcus sera have shown that they resemble cold agglutinin sera with anti-I specificity reacting more strongly with adult human erythrocytes than cord erythrocytes. However, their substantial reaction with iadult erythrocytes suggests that they react with other developmentally regulated antigens in addition to the I and i antigens.

Adult↗
PubMed1975

A vision care module within a prototype HMO.

The Health Maintenance Organization (HMO) concept is dedicated to the prevention of disease and disability. Organizations incorporating this concept must include vision care if complete service is to be offered. Described in this paper is one such HMO, Group Health Cooperative of Puget Sound, with details of the successful integration of optometric vision care into this medically oriented, multidisciplinary setting.

Health Maintenance Organizations↗
PubMedDate not supplied

Child bereavement after paternal suicide.

BACKGROUND: Studies of child suicide survivors are rare and often these studies have not included direct interviews with children. OBJECTIVES: To describe the bereavement process in a sample of prepubertal children whose fathers died by suicide within the previous three years. METHODS: Sixteen prepubertal children, their mothers, and a relative or caretaker were interviewed to examine grief, trauma, and behavior within 25 months of paternal suicide. RESULTS: Reminiscing was the most frequently endorsed grief behavior. Males were more likely than females to score above the standard means for CBCL scores. PTSD scores were significantly related to parental threats of divorce and exposure to death by discovery of the body. CONCLUSIONS: The concept of grief and trauma as separate and overlapping phenomena is supported by the study findings.

Bereavement↗