Biomedical subjects

J Paysant

Publications and source records attributed to J Paysant.

At least 19 recordsLinked to original sources

PubMed2006

[Capacity and performance: ambulatory monitoring under controlled and real-life conditions].

OBJECTIVES: To determine the value of ambulatory monitoring in assessing human gait. To describe the sensors, the parameters and the ambulatory devices. MATERIALS AND METHODS: Literature review and practical experience about techniques, principles, objectives and limits. RESULTS: Accelerometry is the main technique for ambulatory monitoring because of its reliability, pertinence of signals and software developed for interpretation. Simultaneous monitoring of heart rate response is clinically relevant. Pedometers and actimeters can answer precise clinical questions about amount of walking activity. CONCLUSION: Ambulatory monitoring during long periods (one day or more) is important, especially for rehabilitation medicine because it measures the actual patient activity performed and participation. The simultaneous monitoring of environmental conditions of activity should improve the interpretation of the data collected.

Humans↗

PubMed2006

Increasing shoe instep improves gait dynamics in patients with a tibiotalar arthrodesis.

Degenerative osteoarthritis in subtalar and midtarsal joints occurring after tibiotalar arthrodesis may be related to biomechanical factors. For patients with tibiotalar arthrodesis walking with their everyday shoes, the ground reaction force is posterior at heel-off and the maximal foot-tibia dorsiflexion is at its upper limit. We hypothesized that increasing the instep of the shoes would improve these abnormalities. Three-dimensional gait analysis was done in nine patients with ankle arthrodesis fused in the neutral position and for 10 control subjects. Four conditions of walking were tested: barefoot, wearing everyday shoes, wearing everyday shoes with the instep increased by 1 cm, and wearing everyday shoes with the instep increased by 2 cm. In the arthrodesis group, the two modified delayed heel-off shoe conditions shifted the ground reaction force closer to the metatarsal heads at heel-off to a normal range, and reduced the maximal foot and tibia dorsiflexion angle. Based on these results, patients with a tibiotalar arthrodesis in the neutral sagittal position may be advised to choose shoes with an instep of approximately 25 mm.

Analysis of Variance↗

PubMed2006

Eye movements and visuoverbal descriptions exhibit heterogeneous and dissociated patterns before and after prismatic adaptation in unilateral spatial neglect.

This prospective study examined the effects of prismatic adaptation on visual exploration strategies in patients with left unilateral spatial neglect (USN). Photo-oculographic gaze recordings were obtained, as the subjects (28 brain-damaged; 15 control) performed a free visual exploration task before and after a session of prismatic adaptation. (i) Before prismatic adaptation, the pattern of visual exploration described two subgroups of patients (symmetrical exploration of hemispaces - similar to the control subjects, deficient exploration of left hemispace). Twelve of 20 patients failed to describe significant elements in the left part of the displayed image. Several visuoverbal patterns were observed, some dissociating visual exploration and verbal description. (ii) Immediately after prismatic adaptation, patients with asymmetrical visual exploration presented a significant increase in the number of point fixations and saccades in the left hemispace. Patients with symmetrical exploration presented the opposite pattern. Improved pattern of visual exploration contrasted with an absence of improved verbal description. Eye movements and visuoverbal descriptions exhibit heterogeneous and dissociated patterns before and after prismatic adaptation. This results demonstrate that prismatic adaptation has no effect in certain patients, suggesting that therapeutic indications and evaluation of prismatic test results should take into consideration the heterogeneous nature of USN.

Adaptation, Physiological↗

PubMed2005

[Evaluation of amputees].

INTRODUCTION: Review of the literature about evaluation of amputees. MATERIALS AND METHODS: A search of the Medline and Reedoc databases with the key words lower limb amputee, upper limb amputee, evaluation of lower limb amputee, evaluation of upper limb amputee, survey of lower limb amputee, survey of upper limb and the same words in French for reports on the evaluation of amputees. RESULTS: Evaluations of amputees differ according to the level of amputation (lower or upper limb) and age (adult or child). They concern standing balance, walking (lower limb) and the mono- or bimanual prehensile capacities with or without prostheses in daily living activities and leisure (upper limb) as well as quality of life, personal satisfaction, psychological impact and, in particular, coping strategies. DISCUSSION: For lower-limb amputees, tools to evaluate include scales of deambulation, of which few are valid in French, and global scales (on locomotor capacities, quality of life and satisfaction), which have been recently validated, but only one of them is valid in French. For upper-limb amputees, specific and valid tools are not available for adults; however, for children some functional capacity scales in daily activities have been validated and take into account psychomotor development. None of these tools are valid in French, and their use is scattered and limited to validation studies. CONCLUSION: Only a few tools to evaluate amputees are valid in French for adults, and they concern lower-limb amputees only. Validating some of these tools in French is necessary.

Activities of Daily Living↗

PubMed2004

[Clinical and three-dimensional kinematic features of the upper limb after replantation of the hand].

INTRODUCTION: Functional assessments of hand replantation after traumatic amputation are considered as good although frequent deficits of long fingers mobility and hand sensitiveness occur. AIMS: To evaluate the capability of handling and the compensatory mechanisms involved in handling. METHODS: Prospective study in eight right-handed males who had distal amputation of the left upper limb with hand replantation for more than two years. Eight males with paired age and handedness served as control. Skin sensitiveness (thread test), mobility (TAM), functional capability (Box and Blocks test, 400 points test) and occupational outcome were assessed. Three-dimensional analysis (opto-electronic device) of the motion of the trunk and the upper limbs (arm, forearm, hand) was made during a pointing and gripping-shifting maneuver and the time of the related phases was measured (dynamometric cube device). Correlation between clinical assessments and three-dimensional analysis were tested. RESULTS: Patients with replantation had a remarkable recovery of the absolute and relative times of the various phases of the handling maneuver. Only the gripping phase was significantly prolonged in patients, this result was correlated with the deficit in motor function and sensitiveness of the replanted hand. The visual control was higher because of the lack of superficial and deep sensitiveness. Compensatory mechanisms involved a lateral shift of the replanted limb segments, probably attributed to the lateral shift of the trunk. CONCLUSION: Patient with a replanted hand develops a homogenesis displacement of the trunk and the pectoral girdle to compensate the shortening and the reduction in active mobility of the hand. This compensatory mechanism, observed in a small scale in healthy too, is efficient with respect to the handling phases.

Activities of Daily Living↗

PubMed2004

The effect of tibio-talar arthrodesis on foot kinematics and ground reaction force progression during walking.

Degenerative osteoarthritis in the subtalar and mid-tarsal joints occurring after tibio-talar arthrodesis is thought to be a consequence of abnormal foot dynamics. We hypothesized that the forward tilt of the tibia during stance induces early heel-off and alteration of the progression of ground reaction force (GRF) after ankle arthrodesis. Three-dimensional gait analysis was performed on nine patients who had an ankle arthrodesis fused in a neutral position and on ten control subjects. Patients walking barefoot were compared to controls. The GRF progression was shifted forward during mid-stance, heel-off occurred earlier and was associated with less anterior tilt of the tibia and a more posterior position of the GRF with reference to the metatarsal heads. The GRF progression, heel-off and tibial tilt were not significantly different between patients and controls when walking in shoes but the GRF was still more posterior at heel-off. Increasing the walking speed worsened the anomalies of foot dynamics. These alterations of foot dynamics are thought to be associated with pathogenic stresses applied to the mid-foot.

Analysis of Variance↗

PubMed2004

Mirror asomatognosia in right lesions stroke victims.

The objectives of this prospective study were: to search for mirror-induced disorders of the body image in right hemisphere stroke victims using a description task of the contralateral upper limb, to analyze their clinical features, and to discuss possible mechanisms. Sixteen consecutive patients with documented unilateral right hemisphere stroke were examined for asomatognosia at the acute phase of stroke, then at least 2 months after stroke under three test conditions: without a mirror, with a conventional mirror, with an inverted mirror. Video recordings of the tests were analyzed to assess performance. The diagnosis of asomatognosia was retained if the subject reported at least one of three sensations: limb transformation, limb strangeness, and/or limb alienation. During the acute phase, 14/16 patients presented manifestations of asomatognosia. All of these spontaneous manifestations had disappeared 2 months later, but were reactivated in 12 patients when exposed to mirror images. The mirror tests revealed four situations: no disorder (n = 4), asomatognosia with both mirrors (n = 5), asomatognosia with the conventional or inverted mirrors (n = 1 and 5), and asomatognosia with the inverted mirror (n = 1). These manifestations were designated as mirror-asomatognosia, a disorder resulting from adaptations of the procedures leading to reorganization of the internal representations of the body image. These findings suggest there are several such internal representations of the body image and that direct body image and mirror body image would be two specific ones. These clinical manifestations and their evolution over time are an expression of the progressive nature of the underlying compensatory mechanisms made possible by brain plasticity.

Adult↗

PubMed2003

Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness.

In breast cancers, clinical symptoms of inflammation localised around the tumour at the time of diagnosis have been considered to have poor prognosis significance. In this study, the biological mechanisms responsible for the deleterious action of monocytes in cancer were investigated. The incubation of the breast-cancer-derived MDA-MB231 cells with monocytes resulted in an increase in factors involved in cell invasion (i.e. both cancer cells and monocytes-associated urokinase and Tissue Factor, and PAI-1 and MMP-9 secretion). Moreover, the functions of monocytes were also modified. Incubation of monocytes with MDA-MB231 cancer cells resulted in a downregulation in the secretion of the antiproliferative cytokine Oncostatin M, while the apoptotic factor TNF alpha was dramatically increased. However, MDA-MB231 cancer cells have been shown to be resistant towards the apoptotic action of TNF alpha. These findings demonstrate that incubation of MDA-MB231 cancer cells with monocytes induced a crosstalk, which resulted in an increased expression of factors involved in cancer cell invasiveness and in a modification of monocytes function against cancer cells, while inflammatory effects were increased.

Breast Neoplasms↗

PubMed2003

[Comparative study of effort training in deconditioned patients with and without pain. A preliminary study].

INTRODUCTION: The deconditioning or disuse syndrome is a recent nosological entity, based on medical, professional, social and psychological arguments. The aim of the study was to measure the physical condition in deconditioning situation and to evaluate the effectivity of a training program on five chronic painful patients and five painless subjects. METHODS: After determining the physical aspects of the deconditioning syndrome using three tests and evaluating pain, this prospective study evaluated the benefits of a six weeks effort training period called "interval training" in subjects with and without chronic pain. The inclusion criteria were the patient's consent, the absence of etiological treatment of the pain and the absence cardiotropic medication. The data were compared using the t-test of Student. After the training protocol, people were satisfied. A significant increase of Maximum Oxygen Uptake, Maximum Tolerance Power duration of recovery and cardiac adaptation of effort were observed. Pain didn't seem to be a limited factor to cardiac effort training and decreased actively after the program. CONCLUSION: A training effort protocol can help to reduce the deconditioning syndrome whether people are painful or not. The improvements of physical parameters seem to be reinforced by a better self assurance.

Adult↗

PubMed2003

The effect of inturning of the foot on knee kinematics and kinetics in children with treated idiopathic clubfoot.

OBJECTIVE: To assess the effect of internal foot progression angle (inturning) on knee dynamics in children with treated clubfeet. DESIGN: Prospective study dividing a population of clubfeet according to the factor inturning. BACKGROUND: Excessive internal or external foot progression angle increases knee flexion by a backward shift of the ground reaction force to the knee joint in children with cerebral palsy. Similarly, inturning in clubfeet was hypothesized to shift the ground reaction force backwards with reference to the knee joint, increasing the external knee flexion moment and the maximal knee flexion at stance. METHODS: Three-dimensional gait analysis was performed on 20 children with surgically treated clubfeet (n=28) to assess alterations of knee dynamics related to inturning (>7 degrees ) and on 13 normal children. RESULTS: Inturning occurred in 46% of the clubfeet and was associated during stance, at maximal knee flexion, to an increase in maximal knee flexion (+7 degrees ), external knee flexion moment (+60%) and related lever arm to the knee (+100%) and at minimal knee flexion, to a reduction in external knee extension moment (-62%) and related lever arm (-58%). Inturning was associated with a more frequent prolongation of internal knee extension moment and of rectus femoris activity exceeding 50% of stance. CONCLUSION: Inturning in clubfeet is associated with knee dynamics alteration, which might contribute to the long-term development of knee osteoarthritis. RELEVANCE: The therapeutic correction of inturning in clubfeet would be of importance if the consecutive knee dynamics alteration is shown by further studies to contribute to long-term degenerative knee pathology.

Adolescent↗

PubMed2003

[Disorders of the processing of spatial information in patients with right cerebral lesions and left hemi-neglect].

The aim of this research was to identify, analyze and classify disorders in behavior which occur in the use of mirrors in patients with right cerebral damage presenting left visual spatial hemiplegia. This work was based on models of visual information processing. Seven controls and eleven patients with right cerebral damage performed a test involving grasping of an object using only specular information from a conventional mirror and then from an inverted mirror. The controls grasped up all the cubes straight away. They only experienced minor difficulty with the inverted mirror, mainly in relation to lateral displacement. The patients revealed a variety of behaviors: 1) searching for and trying to seize the object in the conventional and/or inverted mirror, 2) inversion of the paralysed side (left versus right) in the inverted mirror or the appearance of a visual spatial hemiplegia, 3) modifications in the order of grasped (from right to left, from left to right, or at random), 4) directional anomalies in the horizontal plane linked (or not) with disorders in the use of the anteroposterior space. The results of this study confirm that the patients have abnormal behavior in mirror spaces. While the characteristics of this behavior shows analogies with those described in the non-recognition of objects and/or defects in the processing of visual information for localising objects in space, they can be disassociated from them, and constitute separate syndromes. Specific terminology and taxonomy for the clinical forms of mirror agnosia and specular agnosia, of mirror paralysis and specular paralysis, and of specular ataxia are proposed.

Adult↗

PubMed2002

Functional asymmetries of the lower limbs. A comparison between clinical assessment of laterality, isokinetic evaluation and electrogoniometric monitoring of knees during walking.

We used bilateral electrogoniometric gait monitoring of the knees to demonstrate the existence of an angular asymmetry between the two legs in healthy subjects. We also searched for correlations between this asymmetry and handedness, footedness and ocular laterality and isokinetic strength of the flexor-extensor muscles of the two knees. Among the 40 subjects studied, 25 (62.5%) showed an asymmetric maximal knee flexion: the difference being superior or equal to 5 degrees between the knees. There was no correlation between this asymmetry and the lateralities studied. We termed this type of asymmetry 'angular preponderance' to differentiate it from the laterality defined by clinical tests. Isokinetic strength of the knee flexors and extensors was correlated with the gender and speed, but not with side or laterality. Appropriate interpretation of lower limb examination should take into consideration angular gait asymmetry in the healthy subject.

Adult↗

PubMed2001

Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules.

Sodium phenylacetate (NaPa), a non-toxic phenylalanine metabolite, has been shown to induce in vivo and in vitro cytostatic and antiproliferative effects on various cell types. In this work, we analysed the effect of NaPa on the invasiveness of breast cancer cell (MDA-MB-231, MCF-7 and MCF-7 ras). Using the highly invasive breast cancer cell line MDA-MB-231, we demonstrated that an 18-hour incubation with NaPa strongly inhibits the cell invasiveness through Matrigel (86% inhibition at 20 mM of NaPa). As cell invasiveness is greatly influenced by the expression of urokinase (u-PA) and its cell surface receptor (u-PAR) as well as the secretion of matrix metalloproteinases (MMP), we tested the effect of NaPa on these parameters. An 18-hour incubation with NaPa did not modify u-PA expression, either on MDA-MB-231 or on MCF-7 and MCF-7 ras cell lines, and induced a small u-PA decrease after 3 days of treatment of MDA-MB-321 with NaPa. In contrast, an 18 h incubation of MDA-MB-231 increased the expression of u-PAR and the secretion of MMP-9. As u-PAR is a ligand for vitronectin, a composant of the extracellular matrix, these data could explain the increased adhesion of MDA-MB-231 to vitronectin, while cell adhesivity of MCF-7 and MCF-7 ras was unmodified by NaPa treatment. NaPa induced also an increased expression of both Lymphocyte Function-Associated-1 (LFA-1) and Intercellular Adhesion Molecule-1 (ICAM-1), which was obvious from 18 hour incubation with NaPa for the MDA-MB-231 cells, but was delayed (3 days) for MCF-7 and MCF-7 ras. Only neutralizing antibodies against LFA-1 reversed the decreased invasiveness of NaPa-treated cells. Therefore we can conclude that the strong inhibition of MDA-MB-231 invasiveness is not due to a decrease in proteases involved in cell migration (u-PA and MMP) but could be related both to the modification of cell structure and an increased expression of adhesion molecules such as u-PAR and LFA-1.

Antineoplastic Agents↗

PubMed2001

Mirror images and unilateral spatial neglect.

Responding correctly to a mirror image requires the creation of a rather peculiar form of dual representation. Mirror agnosia and mirror ataxia, i.e. a deficit in reaching an object reflected in a mirror, have been reported to be associated with parietal lobe lesions. This prospective study was conducted to investigate the capacity of subjects with neglect to identify the mirror image nature of visual information. Four consecutive brain-damaged patients with neglect, selected on the basis of specific criteria, and four control subjects performed grasping and object displacement tests under two response conditions (normal mirror and inverted mirror). Video recordings of the tests were analyzed to assess performance using the following criteria: (i) direction of the arm movement during the initial phase of movement, (ii) number of corrections of the hand position before grasping. The control subjects successfully grasped the objects in both experimental conditions. The patients (1) neglected the contralesional space, grasping objects correctly in the ipsilesional space (normal mirror condition) and (2) neglected the ipsilesional space, grasping correctly objects in the contralesional space (inverted mirror). Controls used real object-centered correction clues to modify the position and direction of their hand movement. The patients only produced horizontal displacements of the upper limb in the "healthy" and neglected space. These results suggest that patients with neglect do not use the same clues and do not modify their procedures as they cannot recalibrate their spatial representations. These differences concerned non-mirror-image clues and directional and positional as well as attentional vectors. Theoretical and rehabilitative implications are discussed.

Adult↗

PubMed2001

[Classification and mechanisms of body perceptions in the amputees].

OBJECTIVE: Amputees can experience several types of physical illusions and phantom limb phenomenon. The objective was to establish a synthetic classification of theses perceptions. METHOD: Prospective study in 75 amputees (group 1: amputation (n = 60), group 2: congenital defect). The subjects were asked first to report their perceptions spontaneously and then to detail the perception, if exist, of the missing limb: form recognition, posture, movement, reminiscence of a lost limb. RESULTS: Different types of perception were described besides the perception of the real state : normal, deformed or commemorative phantom limb and illusion of a normal body. DISCUSSION: Whatever the model (i.e.: neuro-matrix) which support the construction of the scheme and the body image, the representations related to identified perceptions, use various innate, autobiographic and identity frames of references as well as instantaneous peripheral information, treated by reorganized cerebral structures. Each type of perception is related to a particular representation pattern. CONCLUSION: This approach, in accordance with the literature, offers a better understanding of the differences between amelic and amputated subjects and of their perception of any prosthetic equipment.

Amputees↗

PubMed2001

[MRI and leg stump neuroma].

OBJECTIVE: To describe RMI aspects of leg stump neuroma and to evaluate RMI scan interest for neuroma diagnosis and management. POPULATION AND METHOD: During a 2 years period, 224 amputated patients consulting for pain or prostetics problems were studied. In 10 cases, a characteristic pain leads to neurona diagnosis. This is described as a sensation of ascending or descending electric shock induced by the stimulation of an identified point with a reproducible topography. In all these cases, RMI scans were performed. In thirty two other cases, a RMI scan was performed to confirm a pathology (bursitis, bone abnormality) or in order to establish an etiologic diagnosis. Twelve neuromas were diagnosed. RESULTS: RMI scan showed a neuroma in the ten cases with a clinical suspicion and two asymptomatic neuromas were diagnosed out of the 32 patients without clinical suspicion. Medium delay between amputation and neuroma diagnosis is 11,6 year. In six cases, staking was modified and in six other cases, surgery was necessary. In aIl cases, clinical manifestations disappeared. Vanous RMI aspects ofneuromas are described and illustrated. Neuroma is observed on the extremity of a nerve that have a wavy aspect on its top. The neuroma is an oblong structure, with clear limits. There is an hyposignal with Ti sequence and variable signal with T2 and after gadolinium injection. DISCUSSION: RMI scan is a good way to diagnose amputee neuroma. It makes it possible to demonstrate the pathological character of the neuroma. It has to be performed when a neuroma is suspected. It enables to confirm the diagnosis and establish the exact topography and anatomic connection. Mechanical strains role as a factor of discovering the neuroma is discussed because of the concomitant evolution of associated lesions (bursitis, bone edema). Surgical repair takes place after correcting abnormal mechanical strains.

Amputation, Surgical↗

PubMed2001

[Rehabilitation protocols after repairs of zone 2 of the flexor tendon of the hand: presentation and indications].

We report the results of a retrospective study of 47 adult patients corresponding to 54 fingers, operated on in the emergency room at Nancy University Hospital between December 1996 and October 1998. These patients were managed using three different postoperative therapy protocols: passive mobilisation according to the Duran technique, active-passive mobilisation according to the Kleinert technique and immediate active mobilisation as described by Strickland. Patients were evaluated in three different ways; active range of movement obtained according to the Strickland scale, the "400 points" flexor function test and the delay in returning to work. Combining all three evaluations showed a 65% rate of satisfactory results, 22% fair and bad results and 13% ruptures. Analysis according to the re-education technique showed a strong superiority of the Strickland protocol. This now needs to be confirmed by a more extensive prospective study. Delay before return to work is not affected by the type or re-education technique chosen, but side-effects are less frequent with the Strickland method. A result in terms of range of active movement alone did not fully evaluate the result of a flexor tendon repair: functional testing was better at this end and the global "400" points test score gave more useful information than each of its component tests taken individually (Purdue pegboard, Minnesota test, Box and Block). Functional testing seemed more helpful in guiding the medical team in its treatment strategy.

Adult↗

PubMed2001

Vestibular caloric stimulation evokes phantom limb illusions in patients with paraplegia.

STUDY DESIGN: Prospective study. OBJECTIVES: To determine the mechanisms of body illusions in paraplegia patients as compared with the amputee phantom phenomena. METHODS: A vestibular caloric stimulation was performed in 10 consecutive patients with complete section of the spinal cord. Perception of body, before and after stimulation, was classed as illusion of a normal body (lower limbs with normal morphological, postural and kinetic characteristics perceived as before spinal injury), normal phantom (overly vivid perception of all or part of the lower limbs), deformed phantom (perception of all or part of the limbs below the injury level as abnormal in shape, posture, movement or even number), or painful phantom. RESULTS: After vestibular caloric stimulation, nine out of 10 patients stated their perception of body segments below the injury level had changed to normal phantoms or to deformed phantoms (morphological, postural or kinetic changes). Among the four patients who initially had painful limbs, two stated the stimulation greatly relieved their pain. CONCLUSION: The normal or deformed phantom evoked by vestibular stimulation would result from use of identity data or instantaneous data as is observed in amputees. Cerebral remapping following deafferentation could be the origin of the deformed phantoms. Illusions corresponding to phenomena perceived at the time of the accident corresponding to autobiographical engrammes do not appear to be evoked by vestibular stimulation, as is also the case in amputees.

Adult↗