Search PubMed⌕ Search

Biomedical subjects

J Pawlega

Publications and source records attributed to J Pawlega.

At least 19 recordsLinked to original sources
PubMed2000

Understanding variations in survival for colorectal cancer in Europe: a EUROCARE high resolution study.

BACKGROUND: Marked differences in population based survival across Europe were found for colorectal cancers diagnosed in 1985-1989. AIMS: To understand the reasons for these differences in survival in a new analysis of colorectal cancers diagnosed between 1988 and 1991. SUBJECTS: A total of 2720 patients with adenocarcinoma of the large bowel from 11 European cancer registries (CRs). METHODS: We obtained information on stage at diagnosis, diagnostic determinants, and surgical treatment (not routinely collected by CRs) and analysed the data in relation to three year observed survival, calculating relative risks (RRs) of death and adjusting for age, sex, site, stage, and determinants of stage. RESULTS: Three year observed survival rates ranged from 25% (Cracow) to 59% (Modena), and were low in the Thames area (UK) (38%). Survival rates between registries for "resected" patients varied less than those for all patients. When age, sex, and site were considered, RRs ranged from 0.7 (95% confidence intervals (CI) 0.6-0.9) (Modena) to 2.3 (95% CI 1.9-2.9) (Cracow). After further adjustment by stage, between registry RR variation was between 0.8 (95% CI 0.6-0.9) and 1.8 (95% CI 1.5-2.2). Inter-registry RR differences were slightly reduced when the determinants of stage (number of nodes examined and liver imaging) were included in the model. The reduction was marked for the UK registries. CONCLUSIONS: The wide differences across Europe in colorectal cancer survival depend to a large extent on differences in stage at diagnosis. There are wide variations in diagnostic and surgical practices. There was a twofold range in the risk of death from colorectal cancer even after adjustment for surgery and disease stage.

Adenocarcinoma↗
PubMed2000

[Monitoring of bone metastases].

Current knowledge about an incidence of bone metastases, use of bisphosphonates and assessment of response to the treatment are surveyed. The bone metastases are quite frequent in patients with breast and prostate cancers. High doses of intravenous pamidronate are particularly useful in the treatment of these patients. Prior to therapy with bisphosphonate special score elaborated by RE Coleman should be calculated. The new biochemical bone resorption markers especially Ntx i Crosslaps seems to be the most efficient for evaluation metastases response.

Antineoplastic Agents↗
PubMed2000

[Single sigmoidoscopy for screening of colorectal cancer].

Once-only sigmoideoscopy of person aged 57 is successful and safe method of screening of colorectal cancer. However acceptance of invitation to screening was about 25%. Because of that we postulated once-only sigmoideoscopy screening for patients aged 57 hospitalized from other than digestive tract neoplasms causes.

Colonic Polyps↗
PubMed1998

[Current possibilities for the decrease of mortality risk in patients with head and neck cancers].

The frequency, survival rates and risk factors for head and neck cancer were reviewed. The most common site in Poland is larynx, accounting for almost 50% of head and neck sites. The second group (each about 15%) are neoplasms of mouth and lip. The differences in 5-year survival for males and females with cancer of larynx, pharynx and mouth are not significant. Our survival rates are not significantly different from European mean. The main risk factors for head and neck cancer are smoking and alcohol drinking together with rare consumption of fruit and vegetables. Dentists are particularly responsible for early diagnosis of head and neck cancer. Chemioprevention can decrease the risk of second primary cancer and cytogenetic tests should in future decide about primary and secondary prevention.

Europe↗
PubMed1997

Evaluation of certain risk factors for lung cancer in Cracow (Poland)--a case-control study.

The relationship of lung cancer risk to cigarette smoking, occupational exposure, air pollution at permanent residence and usual frequency of consumption of fruits and vegetables was analysed in a case control study in Cracow, Poland. The cases were 176 male lung cancer patients diagnosed in 1992-1994 with histological confirmation of the diagnosis, obtained from the population-based Cracow Cancer Registry, and 341 controls randomly selected from the general population. Classification of exposure to outside air pollution was based on measured level of total suspended particular matter and sulphur dioxide by particular districts of town (from 1973 to 1980). Except calculation of odds ratios for male lung cancer associated with exposures among all study subjects, the association between lung cancer risk and frequency of consumption of fruit and vegetables was examined among drinkers of vodka above average. Risk of lung cancer was increased significantly with increasing number of pack-years of smoking (OR = 18.7 for more than 40 pack-years). The significant inverse association of frequent usual consumption of boiled vegetables was present both among all subjects and among vodka drinkers (OR = 4.6 and 12.5, respectively, for a rare consumption). The risk of male lung cancer was negatively associated with the level of air pollution but positively with the percentage of occupationally exposed. Our study provides no evidence of a significant harmful effect of air pollution and found a strong inverse association between frequent fruit and vegetables consumption and lung cancer risk.

Adult↗
PubMed1996

Dietary factors and risk of prostate cancer in Poland. Results of case-control study.

The relationship between cigarette smoking, vodka drinking and consumption of 44 food items typical of the Polish diet were analyzed in a case-control study performed in Cracow, Poland, among 76 cases of prostate cancer and 152 controls. Cigarette smoking and drinking of vodka were not significantly influencing the prostate cancer. The men who ate smoked or fried fish or liver at least once per week had almost half of the risk of prostate cancer of the men who ate those food rarely.

Aged↗
PubMed1995

[Ovarian cancer and selected life style habits].

Analysis of population based case-control study performed in Cracow Poland in 1988-1990 on 81 cases of histologically proven epithelial ovarian cancer and 162 age matched controls have shown that frequent consumption of legumes was associated with significantly decreased risk. Smoking and drinking of vodka were not significant related to ovary cancer risk.

Adult↗
PubMed1994

[Second primary malignant neoplasms in patients treated radically for carcinoma of oral cavity, larynx and lungs].

About 1% of the patients with oral cavity, larynx, and lung cancer get second primary malignant neoplasms every year. For laryngeal cancer the percentage exceeds 10. Second primary tumors in oral cavity, larynx, and lung cancer patients are also tobacco-related neoplasms. Smoking cessation by patients with oral cavity, larynx, and lung cancer may have significant influence on the prognosis. Vitamin A (retinol) and its analogues are promising for human cancer prevention.

Humans↗
PubMed1993

Survival studies: Cracow Cancer Registry experience.

The experience of the Cracow Cancer Registry is presented to show how useful a population-based survival study can be. Survival rates for lung, breast, and colorectal cancer are compared over two periods of time. In addition, the survival experience of patients treated at the Oncologic Center in Cracow is compared with the U.S. SEER data.

Breast Neoplasms↗
PubMed1992

Breast cancer and smoking, vodka drinking and dietary habits. A case-control study.

The relationship between cigarette smoking, vodka drinking and consumption of 44 food items typical of the Polish diet were analysed in a case-control study in Cracow, Poland, among 127 cases of breast cancer and 250 controls randomly selected from the general population. Cigarette smoking was not significantly influencing the breast cancer risk. Compared with never-drinkers, the habit of vodka drinking 20 years earlier significantly increased breast cancer risk in women below 50 years of age (multivariate OR was 4.4 with 95% CI 1.6-12.4). Frequent consumption of boiled vegetables 20 years earlier (greater than 3 times per week) was associated with a decreased risk of breast cancer in women aged 50 years and more (multivariate OR was 0.4 with 95% CI 0.2-0.8).

Adult↗
PubMed1988

Trends and patterns in lung cancer incidence in four cities of Eastern Europe, 1971-1980.

The trends of age-adjusted and age-specific lung cancer incidence rates showed over the period of 1971-1980 substantial differences in four selected towns of Eastern Europe. The downward age-adjusted trends in males coincided in Berlin with the possible beginning of their downturn in the whole country, while their decline in both sexes in Bratislava could be related to the change of demographis factors. In the other two towns studied--Cracow and Tallinn--the substantial increase of lung cancer incidence in males corresponded with the similar evolution in both respective countries (Poland and Estonia). The rising trends in females in both mentioned towns could be more or less compared with their dramatic increase in some developed countries. The rising trends of age-specific rates in younger age groups of males do not indicate meanwhile the positive influence of low-tar or filter-tipped cigarettes on lung cancer incidence in males observed recently in some countries.

Adult↗