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Biomedical subjects

J Pawlak

Publications and source records attributed to J Pawlak.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Recurrence of primary sclerosing cholangitis in patients after liver transplantation.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease that progresses to end-stage liver disease. There are several specific problems related to the posttransplantation period in these patients. The aim of this study was to analyze a single center experience with 17 orthotopic liver transplantations (OLT) due to PSC. PATIENTS AND METHODS: Seventeen patients were included (10 men, 7 women). Actuarial patient and graft survival rates and the incidence of recurrent sclerosing cholangitis were determined at 1, 5, and 7 years. RESULTS: Fifteen patients received single grafts, whereas two patients required retransplants. Patients received either cyclosporine (n = 7) or tacrolimus (n = 10) based immunosuppression. The 1-, 5-, and 7-year patient survival rates were 80%, 60%, and 60%, respectively, whereas the graft survival rates were 88%, 65%, and 65%, respectively. Two patients had cholangiocarcinomas (CCA) diagnosed during OLT; both recurred within 6 months and had a fatal outcome. Two patients (12%) developed recurrent sclerosing cholangitis, as assessed by liver histology and imaging of biliary tree. CONCLUSIONS: Liver transplantation provides good patient and graft survival rates in cases affected with PSC. CCA is associated with poor recipient survival. Recurrent PSC occurs in approximately 12% of cases but does not significantly affect patient survival.

Adult↗
PubMedDate not supplied

Imaging techniques in patients with biliary obstruction.

The most frequent causes of cholestasis include choledocholithiasis and neoplasms (pancreatic head carcinoma, ampullary carcinoma, cholangiocarcinoma). The authors discussed imaging modalities currently applied in the diagnostics of patients with suspected obstruction biliary tract obstruction. Special attention was paid to the efficacy of these techniques in detecting the obstruction and determining its level and nature. In general, US or CT are first performed in patients with cholestasis. The use of percutaneous cholangiography and retrograde cholangiopancreatography is often limited to therapeutic interventions. Magnetic resonance offers images similar to both conventional cholangiography and computed tomography. This technique offers complex evaluation of bile ducts and other abdominal organs.

Bile Duct Neoplasms↗
PubMedDate not supplied

[Comparative studies on the lipid content of the cerebrospinal fluid and serum lipoprotein fractions in patients with discopathic changes].

The reported investigations were carried out in 12 subjects with low back pains caused by lumbar discopathy. The studied material were cerebrospinal fluid samples obtained during lumbar tap and blood obtained from the antecubital vein. In the fluid, serum and lipoprotein fractions the concentrations of cholesterol, triglycerides and phospholipids were determined. It was found that the concentration of the lipids determined in the cerebrospinal fluid in patients with discopathy was not different from that demonstrated in healthy subjects. The lipid content of the fluid differed significantly from that of the serum but was very similar to the composition of lipids in the high density lipoprotein fraction (HDL). The summed up concentration of cholesterol, triglycerides and phospholipids was about 170 times lower than that in the HDL fraction.

Adult↗