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Biomedical subjects

J Parret

Publications and source records attributed to J Parret.

At least 19 recordsLinked to original sources
PubMed1990

Radioisotopic and biochemical determination of salivary secretion after long term psychotropic therapy.

The aim of this work was to investigate the effect of prolonged psychotropic therapy (neuroleptics and antidepressants over 5 yr on salivary secretion. The flow rate in the parotid and submandibular glands were measured separately by scintigraphy. Flow rates, total protein concentration and total IgA level were determined in the unstimulated saliva in 30 control subjects and 73 patients treated with psychotropic drugs. As evidenced by measurement of flow rates and scintigraphy, psychotropic therapy reduced the unstimulated salivary secretion from parotid glands and to a lesser extent from submandibular gland. The scintigraphic study showed a lower response to stimulation in patients than controls.

Humans↗
PubMed1983

[Sialitis].

Explore the source record for details and available documents.

Aged↗
PubMed1979

[Sialorrhea. Value of isotopic examination (author's transl)].

Three types of sialorrhea can be distinguished: -- deglutition disorders, especially in patients with Parkinson's disease and those with anxiety, -- ptyalomania, -- primary hypersecretion at rest. Functional scintigraphic studies enable a physiological approach to be made, and this tends to group together, under the name of primary hypersecretion at rest, various clinical manifestations occurring in two main groups: -- elderly women complaining of a bitter taste in the mouth, -- plethoric men with large salivary glands. The scintigraphic recording apperances of secretion at rest, which occurs early and without obvious food stimuli, are also noted in other clinical types. It remains to be demonstrated whether they have a common physiopathological basis arising from disorders of the normal sensitivity of the buccal cavity.

Adolescent↗
PubMed1979

[Pathogenesis of reflex secretory dysfunctions. Value of isotopic techniques (author's transl)].

Many hypotheses have been advanced to try to explain the mechanism involved in reflex secretory dysfunctions. The use of dynamic isotopic techniques and their application in clinical research enable a more precise approach to be made to assist in solving the problem. Using several examples of dysfunction of various etiologies, the authors demonstrate the existence of an excretory blocking effect from parasympathetic inhibition.

Atropine↗
PubMed1979

[Hypertrophic sialosis: general review and report on 13 cases (author's transl)].

The authors describe 13 cases of hypertrophic sialosis and discuss possible mechanisms which could explain their appearance. In spite of different etiologies there is uniformity in the reactions produced. The authors therefore compared the clinical findings with those reported from animal experiments in which such lesions were artificially produced. Whether the processes of cellular hyperplasia and hypertrophy observed are related to an autonomic nervous system disorder, is open to question.

Adolescent↗
PubMed1975

[Radioisotopic examination and diagnosis of dryness of the mouth].

The clinical and sialographic opposition between true xerostomia (with continuous disorders) and paradoxical asialia (with inter-prandial disturbance, but sparing mealtime) led the authors to analyze these patient's scintigraphic scannings. A kinetic study of excretion was carried out with gamma-camera recording of intensity and glandular activity: the information thus obtained was set down in a numerical integration block and dealt with by computer. A graph of activity was plotted for each gland showing: - a phase of ascending concentration followed by a plateau corresponding to excretion at rest; - a phase of excretion provoked by a gustatory stimulus (physiological) with a very rapidly descending graph. It is possible to establish a ratio of glandular activity/blood activity at maximum concentration and maximum excretion. From the graphs thus obtained it is possible to perfectly differentiate true xerostomia (no excretion even with stimulation) from paradoxical asialia (no plateau of excretion at rest, but stimulus effective). A better knowledge of "dryness of the mouth" should enable better adapted therapy.

Diagnosis, Differential↗