Search PubMed⌕ Search

Biomedical subjects

J Papp

Publications and source records attributed to J Papp.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Secretin versus cimetidine in the therapy of active bleeding from peptic gastroduodenal lesions. A prospective, randomized, double-blind, multicentric study].

In a multicentric, prospective, double-blind, randomized trial 101 patients with active bleeding (Forrest, Type 1/b) from gastroduodenal ulcers or erosions were treated with secretin (n = 50, dose: 800 clinic units/24 hours) or cimetidine (n = 51, dose: 75 mg/hour). The bleeding and the effect of the therapy were endoscopically confirmed. The bleeding was stopped during 48 hours of treatment in 36 patients of the secretin treated group and in 25 of the cimetidine treated group (p less than 0.05). In 72 hours the control of bleeding was established in a total of 75 patients (41 secretin, 34 cimetidine; not significant). Surgery was necessary in 7 vs. 9 cases. The mortality was 1 vs. 4 cases. The mean transfusion requirements were 6.6 units in secretin- and 8.2 units in cimetidine treated group (p less than 0.01). There was no difference in rebleeding rate. The results show a trend in favour of secretin compared to cimetidine in the treatment of active bleeding from gastroduodenal ulcers or erosions.

Adolescent↗
PubMed1990

[Endoscopic treatment of acute biliary pancreatitis].

The authors examined the possibilities of the endoscopic treatment of acute gallstone pancreatitis on the basis of the results of retrospective investigation of 19 middle-european endoscopic centers. There were altogether 11,830 EST in these centers; in 261 out of them the indication of EST was acute gallstone pancreatitis. They consider the exact and early diagnosis very important that can be based on the typical clinical and laboratory signs and ultrasonography. The ERCP reassures the final diagnosis and at the same time the therapeutic solution--EST--can also be realized. This took place within the first 48 hours. The results were favourable, in 90.4%, the complaints decreased significantly within 24 hours. The complication rate was 4.9%, and the mortality rate was 1.9%. These results are better than those of the conservative therapy.

Ampulla of Vater↗
PubMed1989

[Testosterone-dihydrotestosterone ratio in the differential diagnosis of pancreatic disease].

Serum testosterone (T), dihydrotestosterone (DT) and androstendione (AD) concentration were determined in male patients with pancreatic cancer (n = 14), chronic pancreatitis (n = 26), other malignancies of the gastrointestinal tract (n = 19) and in control subjects (n = 16). The T level was decreased in patients with pancreatic cancer relative to other groups of patients but the difference was not statistically significant. The T/DT ratio was significantly lower in pancreatic cancer (2.5 +/- 1.0) compared to chronic pancreatitis (9.6 +/- 2.3, p 0.01). The specificity of the ratio is 84%, while the sensitivity was found to be 92%. The discriminative value was found to be 4. The T/DT ratio seems to be a valuable marker in the differentiation of pancreatic cancer from chronic pancreatitis.

Diagnosis, Differential↗
PubMed1989

Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: a prospective, randomized, controlled trial.

In a double-blind, prospective, randomized trial, the healing effect of somatostatin was compared with that of cimetidine in 67 patients with endoscopically confirmed duodenal ulcer with active bleeding (33 patients were treated with somatostatin, 34 with cimetidine). Intravenous infusion of either drug was administered for 48 or 72 h. Somatostatin had a higher rate of control of bleeding (30 vs. 24 patients at 72 h; p less than 0.05) and had less mean transfusion requirements (4.4 vs. 5.8 units; p less than 0.01). Need for surgical intervention and the mortality figures show a trend in favor of somatostatin. There was no difference in rebleeding rate.

Aged↗
PubMed1988

[Combined antisecretory therapy in patients with duodenal ulcer].

The ulcer healing effect of the combination of pirenzepine and cimetidine was compared to the cimetidine monotherapy in 60 duodenal ulcer patients, in whom previous cimetidine monotherapy (at the dose of 1000 mg/day for 4 weeks) had not produced any healing effect. The study was conducted in a prospective, double blind, random fashion. In 30 patients the cimetidine monotherapy was continued at the dose of 1000 mg/day. The other 30 patients received the combination of pirenzepine (75 mg/day) and cimetidine (400 mg at bedtime). Endoscopy was carried out before and after 4 weeks therapy. In the cimetidine group the ulcers have been cured in 12 cases. The cure rate was higher with the combination therapy: control endoscopy showed healed ulcers in 24 patients in this group. The difference between the two groups is statistically significant (chi 2-Test: 10.0, p less than 0.001). These results indicated a higher effectiveness of the pirenzepine-cimetidine combination in duodenal ulcer patients who had not previously responded to cimetidine alone.

Adult↗
PubMed1988

[Pirenzepine and cimetidine in the treatment of duodenal ulcer].

The efficacy of pirenzepin--of anticholinergic effect--and the H2-receptor blocking cimetidine has been studied in duodenal ulcer with random, double blind fashion. Recurrence examinations were carried out 6 and 12 months following the treatment. 50 patients were given pirenzepin and 50 cimetidine. The average age of the patients was 44.5 and 43.8 years respectively. Of them 60 (24 + 36) were men and 40 (26 + 14) women. At the start, 6 weeks following the start 6 and 12 months after the finishing of the treatment gastroscopy was performed. In the course of the six-week-long treatment 38 (76%) of the pirenzepin taking patients and 36 (72%) of the cimetidine taking patients recovered. No significant difference was found between the efficacy of the both treatments. In the respect of the half and one year recurrence, no significant difference was observed between the two patient groups. Ten of the patients taking pirenzepin and 4 of those taking cimetidine complained of side effects. Dryness of mouth, visual disturbance in the former group and constipation in the latter one. On the basis of the examinations both secretion inhibitors were found equally suitable for the therapy of duodenal ulcer.

Adult↗
PubMed1987

[Endoscopic diagnosis and therapy of benign stenosis of Vater's papilla].

Out of 921 endoscopic papillotomies (EPT) 110 (12%) were performed in patients with benign stenosis of the papilla of Vater. Among these patients were 96 after cholecystectomy and 14 with gallbladder in situ. The diagnostic aspects of the stenosis of papilla and the complications of EPT were investigated on the basis of these patients. The dilation of the bile ducts is not a specific criteria for the diagnosis of papilla-stenosis. Dilatation could develop after cholecystectomy despite the normal sphincter pressure. The complication rate in patients with stenosis of papilla of Vater is increased (13.6%) in comparison with the patients with biliary stones (8.8%). This can be account for the increased number of haemorrhage and cholangitis.

Ampulla of Vater↗
PubMed1987

[Seasonal disposition of gastroduodenal ulcer--legend or reality?].

The seasonal activity of peptic gastroduodenal ulcers was studied on the basis of 17,106 gastroduodenoscopies which were done during a 10 years period. The activity of gastric and duodenal ulcer was increased only in autumn; their number in spring did not deviate from the average. The frequency of bleeding in duodenal ulcers was increased in autumn, whereas the gastric ulcer-bleeding was detected in more patients during winter. According to this examination the regular spring-autumn periodicity is not typical for the peptic ulcer.

Cross-Sectional Studies↗
PubMed1987

[Endoscopic papillotomy in patients with the gallbladder in situ].

Out of 731 endoscopic papillotomies (EPT), 175 (24%) were performed in patients with gallbladders in place. Gallstones were detected in 91 cases both in the gallbladder and in the bile ducts. The EPT resulted in a symptomless condition in 44 of these cases without surgery. In 47 patients the cholecystectomy became necessary later and since the cholostasis ceased the surgery could be done among better conditions. The EPT is recommended also in patients with gallbladder in situ because the surgery will be for some of these patients after the EPT unnecessary. However in that condition the risk of acute cholecystitis increases after EPT.

Aged↗
PubMed1987

Endoscopy in the diagnosis and treatment of benign stenosis of the papilla of Vater.

Of 921 endoscopic sphincterotomies (EST) performed by the authors, 110 (12%) were done for benign stenosis of papilla of Vater. Based on these data, they consider the possibilities of endoscopic diagnosis and treatment in the stenosis of papilla. One of the conditions for the diagnosis of papilla stenosis is the detectability of dilated biliary tract by endoscopic retrograde cholangiography. But this cannot be taken as a specific sign because, e.g., the biliary tract may become dilated in spite of normal sphincter tone after gall-bladder removal. At the same time, biliary tract dilation is a diagnostic criterion for papilla stenosis, and abnormal findings in biliary scintigraphy and the laboratory syndrome consistent with cholestasis cannot be avoided. EST is the method of first choice in the treatment of papilla stenosis in comparison to surgery. The complications of EST, however, occur in papilla stenosis more frequently than in choledocholithiasis (8.8%). Bleeding and cholangitis are responsible for the excess incidence.

Ampulla of Vater↗