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Biomedical subjects

J Papo

Publications and source records attributed to J Papo.

47 records · Page 3Linked to original sources
PubMed1975

Malignant metastatic insulinoma treated with streptozotocin.

A patient with metastatic insulinoma who suffered from severe hypoglycaemic attacks was treated with 7-5 g of streptozotocin (Upjohn). Shortly after the start of treatment, the hypoglycaemic attacks ceased; fasting blood glucose levels and serum immunoreactive insulin values returned to normal upon completion of the treatment. Two years after treatment, the patient is well and active and has not had any attacks. The oral glucose tolerance test and tolbutamide stimulation test now show serum immunoreactive insulin excretion patterns similar to those seen in diabetics.

Adenoma, Islet Cell↗
PubMedDate not supplied

Radioimmunoguided surgery benefits for recurrent colorectal cancer.

BACKGROUND: Despite new adjuvant therapy, 50% of patients with colon cancer will have recurrent disease. This study investigated the use of a radiolabeled monoclonal antibody in locating occult tumor during surgery for recurrent colorectal cancer. METHODS: Twenty-two patients with recurrent colorectal cancer underwent surgery using the radioimmunoguided surgery (RIGS) system. All patients were subjected to abdominal and chest computed tomography (CT). Before surgery, patients were injected with the CC49 monoclonal antibody (MoAb), anti-TAG antibody labeled with 125I. Ten patients with elevated carcinoembryonic antigen (CEA) levels and no CT findings had a scintigraphy scan with an anti-CEA MoAb labeled with 99Tc. Human antimouse antibody levels of these patients were within normal limits. Surgical exploration including liver ultrasound examination was followed by survey with a gamma-detecting probe (GDP). RESULTS: There was MoAb tumor localization in 100% of the patients. CT found nine tumor sites, traditional surgical exploration 30, and the GDP 51, with 44 confirmed by pathology (hematoxylin and eosin). The RIGS system found occult tumor in 10 patients (45.4%) and resulted in major changes in surgical procedure in 11 patients. In the 10 patients who had scintigraphy scans, 10 tumor sites were identified, whereas RIGS found an additional eight sites. CONCLUSION: RIGS technology offers a substantial benefit for patients undergoing surgery for recurrent colorectal cancer and a better chance of finding recurrent tumor intraoperatively in patients who have elevated CEA levels with no other CT findings.

Abdominal Neoplasms↗
PubMedDate not supplied

Leiomyosarcoma of the colon and rectum.

Leiomyosarcoma of the colon is an uncommon lesion and may appear throughout the colon. Early diagnosis is seldom accomplished before complications such as bleeding or obstruction appear. Sometimes it is histologically difficult to distinguish between a benign and a mlaignant leiomyoma. Some leiomyomas have biologic evidence of malignancy. Five cases of leiomyosarcoma are described, one of which was histologically diagnosed as a leiomyoma, but two years later, at laparotomy, metastases were found.

Adult↗
PubMedDate not supplied

Rupture of a hydatid cyst of the liver into the biliary tract.

Rupture of a hydatid cyst into the biliary tract occurs in 5% to 10% of patients with hydatid disease of the liver. The communication between the hydatid cyst cavity and the biliary tree may produce intermittent or progressive obstructive jaundice. The presence of such jaundice complicates the diagnosis since it resembles other biliary disorders such as stone or infection. We treated six patients with hepatic hydatid cysts, four with minute fissures and two with wide ruptures into the biliary tract. The pathophysiologic mechanisms, diagnostic procedures and treatment are discussed.

Adult↗
PubMedDate not supplied

[Postmortem intraosseous phlebography. Anatomical, topographic and hemodynamic problems].

Intraosseous injection of potassium iodide was carried out at the level of the malleolus and the iliac crests in 90 cadavers. Information concerning the anatomy of the veins and concerning different organs was also obtained. We still need to compare this information with that from in vivo phlebography and the results from biopsy. Radiographic films taken at the moment of injection and at various times up to 60 minutes after injection, show the filling not only of the local veins in the lower extremities or the pelvis, but also a flow of contrast material through the abdominal organs and up to the level of the brachio-cephalic veins. Studies on cadavers in the vertical position show little or no difference. We show the filling of the venous system and especially the hepatic and renal veins. Various considerations on the nature of this dynamic effect in the cadaver are discussed, but this will need further study. There are certainly limits of exactitude for this method in comparison with autopsy. The method is not expected to supersede angiography in living patients. It is rather a complementary technique to be used especially in cases where an in vivo angiographic study is lacking or where a biopsy is impossible. In certain cases it is possible to discover radiologically anatomical lesions which are difficult to detect by autopsy or are easily distorted by this procedure.

Bone and Bones↗