Lipolytic activity of human placenta and lipid mobilizing activity (LMA), free fatty acids (FFA) as well as esterified fatty acid (EFA) levels in serum of pregnant women in different periods of pregnancy and in newborn's serum were studied. Lipolytic activity of human placenta is low in the first trimester of pregnancy and increases in samples examined after delivery. The levels of FFA and EFA in blood of pregnant women are significantly increased in the second and third trimester of pregnancy. The newborn's blood lipid level is significantly lower than that in the mother's blood. Lipid mobilizing activity in serum of pregnant women increases especially in the third trimester of pregnancy and is also high in newborn's blood. This may indicate that fatty acids released from newborn's adipose tissue are metabolized as a source of energy.

Adipose Tissue↗

PubMed1976

Lipid mobilizing activity in the blood of obese patients during prolonged fasting.

Lipid mobilizing activity is lowered in the serum of obese patients. During short-term fasting, this activity increases in non-obese subjects. The present study was concerned with the changes in lipid mobilizing activity in the blood of obese patients during prolonged fasting, and with the behavior of esterified and free fatty acids. Serum levels of free fatty acids in the control subjects were significantly lower than in the obese women. During a 14-day period of complete fasting, levels of free fatty acids increased in all cases. In non-obese subjects this was accompanied by a significant rise in lipid mobilizing acitivity, but in obese subjects no significant change took place in this activity. The findings indicate that high levels of free fatty acids in obese persons during fasting are caused by inhibition of their esterification.

Adult↗

PubMed1975

[Factors regulating free fatty acid blood levels during postprandial lipemia].

Explore the source record for details and available documents.

Adipose Tissue↗

PubMed1975

Factors regulating blood levels of free fatty acids during alimentary lipemia.

Transient lowering of blood levels of free fatty acids (FFA) in man and experimental animals after ingestion of fat has been noted by many investigators and has been attributed to inhibition of mobilization of fatty acids from adipose tissue. Studies on lipid mobilizing activity in in vitro systems containing glucagon, insulin and anti-insulin anti-bodies as factors modifying lipolysis indicate that insulin is the basic inhibitor of lipolysis in the blood in the period immediately following feeding of animals. This observation has been confirmed by direct determinations of insulin levels by the radioimmunologic method. Experiments in which substances influencing activity of the autonomic nervous system were used show that ingestion of fats stimulates insulin secretion as a result of cholinergic stimulation. Studies on lipolytic activity of blood serum confirmed an essential role of lipoprotein lipase in the mechanism of deposition of triglycerides in adipose tissue during alimentary lipemia. The role of prostaglandins and intestinal hormones (enteroinsular axis) in the mechanism of regulation of FFA levels during alimentary lipemia is also discussed.

Adipose Tissue↗

PubMed1974