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J Palou Redorta

Publications and source records attributed to J Palou Redorta.

At least 19 recordsLinked to original sources
PubMed2006

[Hormone-refractory prostate cancer. Modifications of the therapeutic strategies since chemotherapy proved its usefulness].

Back in the 90's it was difficult to have access to the conclusions of publications on HRPC. Homogeneity was very scarce regarding issues as significant as the definition of HRPC itself, patient selection, or evaluation of the responses to therapy. Consensus has currently been reached on such matters, and it is described in this text. Two works were published in late 2004 showing that docetaxel-based chemotherapy improved metastatic HRPC survival. Until then, the different treatments used could only provide symptomatic relief. But probably not all of the HRPC patients are eligible for primary docetaxel chemotherapy. The current debate focuses on determinating to which patients should chemotherapy be administered and at which time should it start, in order to exclude those patients at risk of experiencing its adverse effects without benefitting from its clinical advantages. Non-metastatic HRPC patients may be candidates to receiving secondary hormone manoeuvres before starting with chemotherapy. We will analyse in this review the changes occurred in the therapeutic strategies ever since chemotherapy showed its value, and we shall also disclose our attitude regarding treatment of these patients in daily practice.

Androgen Antagonists↗
PubMed2006

[Transperitoneal laparoscopic partial nephrectomy in the renal tumor treatment].

Laparoscopic surgery is a surgical technique the urologist should add to his surgical armamentarium. Its performance tries to mimic the surgical phases of open surgery, and also its indications. Laparoscopic partial nephrectomy is a sophisticated technique that requires wide experience in the performance of endoscopic strategies. We are submitting our experience with 35 laparoscopic partial transperitoneal nephrectomies with a mean follow-up of 25 months. The mean surgical time was 200 minutes, the mean bleeding 190 cc, and the mean hospitalisation five days. Two postoperative bleedings were identified, there were no conversions, and positive margins were notified in two cases, where upon a conservative attitude was adopted.

Adult↗
PubMed2006

[Prognostic factor and prediction tables for clinically localized prostate cancer].

INTRODUCTION AND OBJECTIVES: To identify the independent prognostic factors of prostate cancer and to develop a table for predicting the probabilities of not-localised prostate cancer occurrence, thus permitting to restrict the radical prostatectomy indication to those patients who have greater probabilities of being cured by the procedure. METHODS: 1293 patients with clinically localised prostate cancer, with histories of neither hormone therapy nor prostate radiation therapy, in whom radical prostatectomy was performed during the period 1990-2003, were retrospectively evaluated. In order to analyse the prognostic factors, logistic regression was carried out by studying all the potential confusion and interaction factors, and by introducing the independent variables in a forward fashion with the following criteria: BCON(0.0001) LCON(0.00001) ITER(50) POUT(0.1). The prognostic variables were categorised, and the prediction table of the not-localised prostate cancer probability was developed from them. RESULTS: Clinical stage, prostatic specific antigen and Gleason's "grade" were identified as prognostic factors, taking into account that the higher they are, the higher the probability of not-localised prostate cancer occurrence. Logistic regression enabled us to develop a table to predict the probability of not-localised prostate cancer in which, taking a 50% probability as the cutoff point, a 26.13% sensitivity and a 94.65% specificity are obtained. The pathological examination of the prostate and the lymphadenectomy showed that, globally, 70% of the tumours were localised. CONCLUSIONS: Application of tables to predicting the probability of having not-localised prostate cancer offers the possibility of improving the prognostic accuracy of the so-called "risk groups", and enables to issue a therapeutic indication better adjusted to the actual status of the disease.

Adult↗
PubMed2005

[Percutaneous treatment with BCG in multiple upper tract transitional cell carcinoma].

Upper tract transitional cell carcinoma is a low prevalent tumour and frequently associated to bladder carcinoma. The antegrade endoscopic access represents a safe, efficient and minimally invasive access. The association to immunotherapy seems effective in decreasing recurrence. We present one patient with multiple upper tract carcinoma treated with percutaneous surgery and BCG.

Adjuvants, Immunologic↗
PubMed2002

Bladder neoplasms after nephroureterectomy: does the surgery of the lower ureter, transurethral resection or open surgery, influence the evolution?

OBJECTIVE: Nephroureterectomy is the treatment of choice for tumors of the upper urinary tract (UUTT). In 1952, a modified version of this technique was described, involving endoscopic detachment of the ureter followed by nephroureterectomy with a single lumbar incision. We reviewed a retrospective survey to assess whether UUTT patients treated with nephroureterectomy with no prior history of bladder tumor had different rates of incidence or different sites of bladder recurrence according to the specific technique employed. METHODS: Patients were divided into group A, 87 patients who underwent a double incision nephroureterectomy and group B with 58 patients with prior detachment of the ureter. In both groups, incidence was calculated for two variables (bladder tumor recurrences and homolaterality of such recurrences) and chi-square tested. RESULTS: Bladder tumor was diagnosed at follow-up in 39% of patients in group A and 34.5% in group B, with no statistically significant difference (N.S.). Bladder tumor recurrences were homolateral to UUTT in 50% of group A cases and 55% of group B cases (N.S.). CONCLUSIONS: Although this is a retrospective survey of two asynchronous groups, given the similar nature of the UUTT cases in both groups and the fact that no statistically significant differences have been found, it is reasonable to conclude that nephroureterectomy with prior endoscopic detachment of the ureter is a safe and radical procedure.

Adult↗
PubMed2000

[Bacteriologic assessment of the lower urinary tract and genital area in patients with recurrent urinary tract infections].

OBJECTIVE: The pathogens responsible for urinary infection originate from the digestive tract prior passage through the genital region. Samples were obtained from this region in an attempt to identify women with these pathogens. We have analyzed the most frequently colonized areas of the genital region in order to develop a method for obtaining samples. Risk factors were evaluated by determining the relationship of the samples with factors implicated in the pathogenesis of recurrent infection. METHODS: Samples were obtained from 146 women of all ages that consulted for recurrent urinary tract infection. The samples from the genital region (perimeatal vulva, vagina, urethral and intraurethral meatus) and urine obtained through a catheter were cultured. RESULTS: The overall incidence of positive samples was 41%; 23% of the patients showed urinary infection (urine obtained by catheterization) at the time the samples were taken. The vaginal samples were the most frequently colonized and the intraurethral samples were the most sensitive when compared with the urinary samples. The sensitivity, specificity, positive and negative predictive values of these two samples were the same as those of the other samples together. In regard to colonization, a difference was found only between menopausal and premenopausal women, and in proportion to the duration of the history of infection. CONCLUSIONS: The study shows that it is unnecessary to obtain various samples; vaginal and intraurethral smears are sufficient. Menopausal women who referred two symptomatic episodes a year were found to be at a higher risk for vaginal infection, and in proportion to the number of years they have had recurrent infection.

Adult↗
PubMed1999

[BCG and radiotherapy: the compatibility of 2 conservative treatments for cancer of the urinary bladder].

OBJECTIVE: To review the efficacy of radiotherapy and BCG in the treatment of transitional cell carcinoma of the urinary bladder in its different forms of presentation, with special reference to patients with infiltrating bladder tumors receiving radiotherapy and those in whom the lesion recurs as a high grade superficial bladder tumor. METHODS/RESULTS: 10 patients who previously received radiotherapy for T2-4 infiltrating bladder tumor that recurred as a high grade superficial tumor were treated with BCG. Four patients are alive and disease-free with a preserved bladder at 2-8 years follow-up. Four other patients who required cystectomy for persistence or progression of the tumor to the bladder wall, are alive and disease free at 3-7 years follow-up. The remaining two patients who were not amenable to major surgery died from the disease more than two years after treatment with BCG. BCG was well-tolerated by 70% of the patients and the rest showed minor complications. CONCLUSIONS: 28.3% of recurrences after radiotherapy are superficial tumors and 7% are carcinoma in situ. The appearance of carcinoma in situ or T1 G3 lesions following radiotherapy of the bladder questions its efficacy against these superficial forms for which cystectomy is reserved. BCG has been found to be effective in high grade superficial bladder tumors that have not been previously irradiated, therefore it would be acceptable to extend its application to those patients in whom radiotherapy has achieved control of the infiltrating tumor but not the high grade superficial tumor. The 40-70% of patients who are alive with a preserved bladder appears to be sufficient to recommend BCG salvage for high grade superficial bladder tumors post-radiotherapy. BCG therapy does not entail major complications or compromise patient survival, including those cases that will require cystectomy.

BCG Vaccine↗
PubMed1998

The role of antibiotics in the treatment of chronic prostatitis: a consensus statement.

Practical guidelines for the diagnosis and treatment of chronic prostatitis are presented. Chronic prostatitis is classified as chronic bacterial prostatitis (culture-positive) and chronic inflammatory prostatitis (culture-negative). If chronic bacterial prostatitis is suspected, based on relevant symptoms or recurrent UTIs, underlying urological conditions should be excluded by the following tests: rectal examination, midstream urine culture and residual urine. The diagnosis should be confirmed by the Meares and Stamey technique. Antibiotic therapy is recommended for acute exacerbations of chronic prostatitis, chronic bacterial prostatitis and chronic inflammatory prostatitis, if there is clinical, bacteriological or supporting immunological evidence of prostate infection. Unless a patient presents with fever, antibiotic treatment should not be initiated immediately except in cases of acute prostatitis or acute episodes in a patient with chronic bacterial prostatitis. The work-up, with the appropriate investigations should be done first, within a reasonable time period which, preferably, should not be longer than 1 week. During this period, nonspecific treatment, such as appropriate analgesia to relieve symptoms, should be given. The minimum duration of antibiotic treatment should be 2-4 weeks. If there is no improvement in symptoms, treatment should be stopped and reconsidered. However, if there is improvement, it should be continued for at least a further 2-4 weeks to achieve clinical cure and, hopefully, eradication of the causative pathogen. Antibiotic treatment should not be given for 6-8 weeks without an appraisal of its effectiveness. Currently used antibiotics are reviewed. Of these, the fluoroquinolones ofloxacin and ciprofloxacin are recommended because of their favourable antibacterial spectrum and pharmacokinetic profile. A number of clinical trials are recommended and a standard study design is proposed to help resolve some outstanding issues.

Anti-Bacterial Agents↗
PubMed1998

[Lumbar ureteral fistula after aortobifemoral bypass in a patient with ileal conduit and pelvic irradiation].

Contribution of a complex case of lumbar ureteral fistula with secondary abscess after aortobifemoral bypass in a patient with a background of radical cystectomy with ileal conduit and pelvic radiotherapy. A nephrostomy was established and the retroperitoneal collection was drained so that in a second phase ureteral replacement with ileum could be performed using uretero-ileal terminoterminal and ileum-ileal terminolateral by-pass with good therapeutic and functional results.

Aged↗
PubMed1997

[Radical nephrectomy following heart transplantation].

Renal cell carcinoma (RCC) is a common neoplasm of the urinary tract, that is nowadays often diagnosed incidentally. The risk of developing neoplasms in immunosuppressed patients is well documented. The increasing rate of heart transplantation, and the complementary studies required in the follow up of those patients probably will increase the detection rate of RCC in this population. Due the lack of published reports about the management and evolution of RCC in these patients, we performed a radical nephrectomy, on a immunosuppressed patient without evidence of recurrence 24 moths after surgery.

Heart Transplantation↗
PubMed1995

Reversible acute renal failure due to sulfonamide-induced lithiasis in an AIDS patient.

OBJECTIVE: Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDS patient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emergency room in acute renal failure. METHODS/RESULTS: Obstructive uropathy due to radiolucent calculi was suspected and retrograde ureteral catheterization was necessary. The calculi recovered were identified as N-acetyl sulfadiazine by infrared spectrophotometry. CONCLUSION: Rapid improvement can be achieved in these patients when the drug is discontinued or decrease and systemic fluid and urine alkalinization are started.

AIDS-Related Opportunistic Infections↗
PubMed1994

[Transurethral resection versus transurethral incision in benign prostate hypertrophy --critical assessment].

We evaluated 665 patients who had undergone TURP and 100 patients who had undergone TUIP (50 bilateral, 50 unilateral). Transurethral incision, when indicated (less than 35 gm, no middle lobe), had the following advantages: easy to perform, short operating time (39 minutes) and hospitalization (3-4 days). There was less bleeding; 2% versus 6% for TURP. The complication rate was lower: no bladder neck sclerosis for TUIP versus 2.9% for TURP; urethral stenosis: 6% for the bilateral and 0% for the unilateral incision versus 8.7% for TURP, and the incidence of retrograde ejaculation was 24% for the bilateral and 19% for the unilateral incision versus 82% for TURP. We also evaluated the disadvantages of transurethral incision: no tissue for study 4% incidental prostate cancer for TURP, limited indications, anatomic variability, less disobstructive, reoperation rate was 10% versus 11.7% for TURP, design of comparative studies deficient and no long-term follow up. The results of bilateral and unilateral incision were compared, however no statistically significant differences were observed. The bilateral incision procedure was slightly more disobstructive: 92% clinical improvement for the bilateral and 84% for the unilateral, increased flow was 6.5% for the bilateral versus 5.6% unilateral, and the reoperation rates were 2% for the bilateral and 8% for the unilateral incision procedure. However, there were less complications for the unilateral incision procedure: no stenosis for the unilateral and 6% for the bilateral, and retrograde ejaculation was 81% for the unilateral and 76% for the bilateral incision procedure. For all the foregoing reasons, we prefer to do unilateral incision of the prostate.

Aged↗
PubMed1992

[Usefulness of catheter pyelography in ileal diversions and continent bladder replacement after radical cystectomy].

Transcatheter ascending pyelography is commonly performed in the post-operative evaluation of patients submitted to ileal diversion or continent bladder replacement after radical cystectomy. The present study investigated the usefulness of this procedure in the control of these patients. Of 51 patients that underwent cutaneous ileal diversion, the IVP revealed a leak of the contrast medium in only one case (1.9%). Of the 18 patients that received a continent neobladder, radiologic signs of changes were detected in 6 cases (33.3%). The complications of the IVP in our patients were fever in 26 patients (37.7%) and septicemia in one patient (1.45%). Considering the information obtained and the rate of morbility, we believe that ascending pyelography through catheters is not justified in the routine post-operative control of patients who have undergone radical cystectomy and ileal diversion. However, it appears to be a useful procedure in those cases that have undergone bladder replacement and/or continent diversion procedures.

Cystectomy↗